, Volume 55, Issue 3, pp 666–681 | Cite as

The influence of phthalates and bisphenol A on the obesity development and glucose metabolism disorders

  • Milica Medic Stojanoska
  • Natasa Milosevic
  • Natasa Milic
  • Ludovico Abenavoli


The prevalence of obesity and type 2 diabetes mellitus epidemics presents a great health problem worldwide. Beside the changes in diet and decreased physical activity, there is growing interest in endocrine disrupting chemicals that may have effects on these conditions. Among them, the role of certain phthalates and bisphenol A is confirmed. We have summarized the existing literature on this issue including cross-sectional, follow up epidemiological studies and in vivo and in vitro studies. Most data support the effects of bisphenol A and some phthalates, such as di-2-ethyl-hexyl phthalate, diethyl phthalate, dibuthyl phthalate, dimethyl phthalate, dibenzyl phthalate, diisononyl phthalate and others on the development obesity and type 2 diabetes mellitus. These endocrine disrupting chemicals interfere with different cell signaling pathways involved in weight and glucose homeostasis. Since the data are rather inconsistent, there is a need for new, well-designed prospective studies.


Phthalates Bisphenol A Obesity Glucose metabolism Metabolic syndrome 



This article was funded by the project No. 175033 by the Ministry of Education, Science and Technological Development of the Republic of Serbia.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.University of Novi Sad, Faculty of Medicine, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of VojvodinaNovi SadSerbia
  2. 2.University of Novi Sad, Faculty of Medicine, Department of PharmacyNovi SadSerbia
  3. 3.University Magna Graecia, Department of Health Sciences, Campus GermanetoCatanzaroItaly

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