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Glycated albumin: from biochemistry and laboratory medicine to clinical practice

Endocrine volume 55, pages 682–690 (2017)Cite this article

Abstract

This review summarizes current knowledge about glycated albumin. We review the changes induced by glycation on the properties of albumin, the pathological implications of high glycated albumin levels, glycated albumin quantification methods, and the use of glycated albumin as a complementary biomarker for diabetes mellitus diagnosis and monitoring and for dealing with long-term complications. The advantages and limits of this biomarker in different clinical settings are also discussed.

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Acknowledgments

We thank Ms Judith Baggott for English-language editing.

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Affiliations

  1. Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133, Milan, Italy

    Elena Dozio & Massimiliano Marco Corsi Romanelli

  2. Instrumentation Laboratory—A Werfen Company, R&D Department, Viale Monza 338, 20128, Milan, Italy

    Nicola Di Gaetano

  3. Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, University Hospital Mannheim, Theodor Kutzer Ufer 1-3, 68167, Mannheim, Germany

    Peter Findeisen

  4. Service of Laboratory Medicine 1—Clinical Pathology, I.R.C.C.S. Policlinico San Donato, Piazza E. Malan 1, 20097, San Donato Milanese, Milan, Italy

    Massimiliano Marco Corsi Romanelli

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  1. Elena Dozio
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  2. Nicola Di Gaetano
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  3. Peter Findeisen
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  4. Massimiliano Marco Corsi Romanelli
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Correspondence to Massimiliano Marco Corsi Romanelli.

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Dozio, E., Di Gaetano, N., Findeisen, P. et al. Glycated albumin: from biochemistry and laboratory medicine to clinical practice. Endocrine 55, 682–690 (2017). https://doi.org/10.1007/s12020-016-1091-6

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  • DOI: https://doi.org/10.1007/s12020-016-1091-6

Keywords

  • Albumin
  • Cardiovascular risk
  • Diabetes mellitus
  • Diabetes mellitus-related complications
  • Glycated albumin
  • Glycation