Skip to main content

Advertisement

SpringerLink
Log in

Thyroid hormone levels in the cerebrospinal fluid correlate with disease severity in euthyroid patients with Alzheimer’s disease

  • Research Letter
  • Published:
Endocrine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. S. Volpato, J.M. Guralnik, L.P. Fried, A.T. Remaley, A.R. Cappola, L.J. Launer, Serum thyroxine level and cognitive decline in euthyroid older women. Neurology 58(7), 1055–1061 (2002). doi:10.1212/WNL.58.7.1055

    Article  CAS  PubMed  Google Scholar 

  2. M. Ganguli, L.A. Burmeister, E.C. Seaberg, S. Belle, S.T. DeKosky, Association between dementia and elevated TSH: a community-based study. Biol. Psychiatry 40(8), 714–725 (1996). doi:10.1016/0006-3223(95)00489-0

    Article  CAS  PubMed  Google Scholar 

  3. J.D. Davis, A. Podolanczuk, J.E. Donahue, E. Stopa, J.V. Hennessey, L.-G. Luo et al., Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer’s disease patients. Current Aging Sci. 1(3), 175–181 (2008). doi:10.1016/j.bbi.2008.05.010

    Article  CAS  Google Scholar 

  4. S. Sampaolo, A. Campos-Barros, G. Mazziotti, S. Carlomagno, V. Sannino, G. Amato et al., Increased cerebrospinal fluid levels of 3,3′,5′-triiodothyronine in patients with Alzheimer’s disease. J. Clin. Endocrinol. Metab. 90(1), 198–202 (2005). doi:10.1210/jc.2004-1083

    Article  CAS  PubMed  Google Scholar 

  5. P. Johansson, E.G. Almqvist, J.-O. Johansson, N. Mattsson, O. Hansson, A. Wallin et al., Reduced cerebrospinal fluid level of thyroxine in patients with Alzheimer’s disease. Psychoneuroendocrinology 38(7), 1058–1066 (2013). doi:10.1016/j.psyneuen.2012.10.012

    Article  CAS  PubMed  Google Scholar 

  6. O.P. Soldin, S.J. Soldin, Thyroid hormone testing by tandem mass spectrometry. Clin. Biochem. 44(1), 89–94 (2011). doi:10.1016/j.clinbiochem.2010.07.020

    Article  CAS  PubMed  Google Scholar 

  7. G.M. McKhann, D.S. Knopman, H. Chertkow, B.T. Hyman, C.R. Jack, C.H. Kawas et al., The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s Dement. 7(3), 263–269 (2011). doi:10.1016/j.jalz.2011.03.005

    Article  Google Scholar 

  8. M.F. Folstein, S.E. Folstein, P.R. McHugh. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12(3), 189–198 (1975). http://www.ncbi.nlm.nih.gov/pubmed/1202204

  9. H. Reiber, K. Felgenhauer. Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin. Chim. Acta 163(3), 319–328 (1987). http://www.ncbi.nlm.nih.gov/pubmed/3581475

  10. G. Tibbling, H. Link, S. Ohman, Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values. Scand. J. Clin. Lab. Invest. 37(5), 385–390 (1977). doi:10.1080/00365517709091496

    Article  CAS  PubMed  Google Scholar 

  11. A. Saba, G. Chiellini, S. Frascarelli, M. Marchini, S. Ghelardoni, A. Raffaelli et al., Tissue distribution and cardiac metabolism of 3-iodothyronamine. Endocrinology 151(10), 5063–5073 (2010). doi:10.1210/en.2010-0491

    Article  CAS  PubMed  Google Scholar 

  12. B.K. Matuszewski, M.L. Constanzer, C.M. Chavez-Eng. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal. Chem. 75(13), 3019–3030 (2003). http://www.ncbi.nlm.nih.gov/pubmed/12964746

  13. P.J. Taylor, Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography-electrospray-tandem mass spectrometry. Clin. Biochem. 38(4), 328–334 (2005). doi:10.1016/j.clinbiochem.2004.11.007

    Article  CAS  PubMed  Google Scholar 

  14. M.B. Dratman, F.L. Crutchfield, M.B Schoenhoff. Transport of iodothyronines from bloodstream to brain: contributions by blood:brain and choroid plexus: cerebrospinal fluid barriers. Brain Res. 554(1–2), 229–236 (1991). http://www.ncbi.nlm.nih.gov/pubmed/1933305

  15. A. Alkemade, E.C. Friesema, U.A. Unmehopa, B.O. Fabriek, G.G. Kuiper, J.L. Leonard et al., Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. J. Clin. Endocrinol. Metab. 90(7), 4322–4334 (2005). doi:10.1210/jc.2004-2567

    Article  CAS  PubMed  Google Scholar 

  16. H.M. Tu, S.W. Kim, D. Salvatore, T. Bartha, G. Legradi, P.R. Larsen, R.M. Lechan, Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology 138(8), 3359–3368 (1997). doi:10.1210/endo.138.8.5318

    CAS  PubMed  Google Scholar 

  17. L. Luo, E.G. Stopa, Thyrotropin releasing hormone inhibits tau phosphorylation by dual signaling pathways in hippocampal neurons. J. Alzheimer’s Dis. 6(5), 527–536 (2004)

    CAS  Google Scholar 

  18. M.J. Latasa, B. Belandia, A. Pascual, Thyroid hormones regulate beta-amyloid gene splicing and protein secretion in neuroblastoma cells. Endocrinology 139(6), 2692–2698 (1998). doi:10.1210/endo.139.6.6033

    CAS  Google Scholar 

  19. N. Kimura, T. Kumamoto, H. Masuda, T. Hanaoka, Y. Hazama, T. Okazaki, R. Arakawa. Relationship between thyroid hormone levels and regional cerebral blood flow in Alzheimer disease. Alzheimer Dis. Assoc. Disord. 25(2), 138–143 (2011). doi:10.1097/WAD.0b013e3181f9aff2

  20. M. Haji, N. Kimura, T. Hanaoka, Y. Aso, M. Takemaru, T. Hirano, E. Matsubara, Evaluation of regional cerebral blood flow in Alzheimer’s disease patients with subclinical hypothyroidism. Dement. Geriatr. Cogn. Disord. 39(5–6), 360–367 (2015). doi:10.1159/000375298

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

This work was supported by a local Grant of University of Pisa to RZ.

Author information

Authors and Affiliations

  1. Scuola Superiore di Studi Universitari e di Perfezionamento Sant’Anna, Pisa, Italy

    Alice Accorroni

  2. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

    Filippo Sean Giorgi, Andrea Vergallo, Gloria Tognoni, Gabriele Siciliano, Filippo Baldacci & Ubaldo Bonuccelli

  3. Department of Pathology, Laboratory of Biochemistry, University of Pisa, Pisa, Italy

    Riccardo Donzelli, Leonardo Lorenzini, Alessandro Saba & Riccardo Zucchi

  4. Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy

    Concetta Prontera & Aldo Clerico

Authors
  1. Alice Accorroni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Filippo Sean Giorgi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Riccardo Donzelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Leonardo Lorenzini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Concetta Prontera
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alessandro Saba
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Andrea Vergallo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Gloria Tognoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Gabriele Siciliano
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Filippo Baldacci
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Ubaldo Bonuccelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Aldo Clerico
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Riccardo Zucchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Riccardo Zucchi.

Ethics declarations

Conflict of Interest

There is no conflict of interest for any author.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 17 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Accorroni, A., Giorgi, F.S., Donzelli, R. et al. Thyroid hormone levels in the cerebrospinal fluid correlate with disease severity in euthyroid patients with Alzheimer’s disease. Endocrine 55, 981–984 (2017). https://doi.org/10.1007/s12020-016-0897-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-016-0897-6

Keywords

Search

Navigation