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Vitamin D-binding protein and free vitamin D concentrations in acromegaly

Endocrine volume 52, pages 374–379 (2016)Cite this article

Abstract

Free 25-hydroxyvitamin D [25(OH)D] is suggested to be important in the determination of vitamin D deficiency, since vitamin D-binding protein (VDBP) may affect total 25(OH)D levels. There are no data about free 25(OH)D concentrations in acromegaly. We aimed to investigate serum VDBP and total and free 25(OH)D levels in patients with acromegaly in comparison with control subjects. We recruited 54 patients with acromegaly and 32 control subjects who were similar according to age, gender, and body mass index. Serum VDBP levels were found to be increased in patients with acromegaly compared to control subjects [90.35 (72.45–111.10) vs. 69.52 (63.89–80.13) mg/l, p = 0.001]. There was statistically no significant difference in serum total 25(OH)D levels between the patients with acromegaly and control subjects [18.63 (13.35–27.73) vs. 22.51 (19.20–28.96) ng/ml, p = 0.05]. Free 25(OH)D levels were significantly decreased in patients with acromegaly compared to control subjects [14.55 (10.45–21.45) vs. 17.75 (15.30–23.75) pg/ml, p = 0.03]. Free 25(OH)D levels correlated positively with total 25(OH)D (p = 0.0001) and HDL cholesterol (p = 0.04) and negatively with fasting blood glucose (p = 0.04). Our findings indicate that VDBP is increased and free 25(OH)D is decreased in acromegaly, while there is no significant alteration in total 25(OH)D.

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References

  1. L. Lieben, G. Carmeliet, R. Masuyama, Calcemic actions of vitamin D: effects on the intestine, kidney and bone. Best Pract. Res. Clin. Endocrinol. Metab. 25, 561–572 (2011)

    CAS  Article  PubMed  Google Scholar 

  2. A.R. Menezes, M.C. Lamb, C.J. Lavie, J.J. DiNicolantonio, Vitamin D and atherosclerosis. Curr. Opin. Cardiol. 29, 571–577 (2014)

    Article  PubMed  Google Scholar 

  3. Y. Song, L. Wang, A.G. Pittas, L.C. Del Gobbo, C. Zhang, J.E. Manson, F.B. Hu, Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 36, 1422–1428 (2013)

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  4. J.P. Forman, G.C. Curhan, E.N. Taylor, Plasma 25-hydroxy vitamin D levels and risk of incident hypertension among young women. Hypertension 52, 828–832 (2008)

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. C. Berg, S. Petersenn, H. Lahner, B.L. Herrmann, M. Buchfelder, M. Droste, G.K. Stalla, C.J. Strasburger, U. Roggenbuck, N. Lehmann, S. Moebus, K.H. Jockel, S. Mohlenkamp, R. Erbel, B. Saller, K. Mann, Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control. J. Clin. Endocrinol. Metab. 95, 3648–3656 (2010)

    CAS  Article  PubMed  Google Scholar 

  6. G. Mazziotti, E. Biagioli, F. Maffezzoni, M. Spinello, V. Serra, R. Maroldi, I. Floriani, A. Giustina, Bone turnover, bone mineral density, and fracture risk in acromegaly: a meta-analysis. J. Clin. Endocrinol. Metab. 100, 384–394 (2015)

    CAS  Article  PubMed  Google Scholar 

  7. S. Takamoto, H. Tsuchiya, T. Onishi, S. Morimoto, S. Imanaka, S. Mori, Y. Seino, T. Uozumi, Y. Kumahara, Changes in calcium homeostasis in acromegaly treated by pituitary adenomectomy. J. Clin. Endocrinol. Metab. 61, 7–11 (1985)

    CAS  Article  PubMed  Google Scholar 

  8. S. Bonadonna, G. Mazziotti, M. Nuzzo, A. Bianchi, A. Fusco, L. De Marinis, A. Giustina, Increased prevalence of radiological spinal deformities in active acromegaly: a cross-sectional study in postmenopausal women. J. Bone Miner. Res. 20, 1837–1844 (2005)

    Article  PubMed  Google Scholar 

  9. P. Kamenicky, A. Blanchard, C. Gauci, S. Salenave, A. Letierce, M. Lombes, S. Brailly-Tabard, M. Azizi, D. Prie, J.C. Souberbielle, P. Chanson, Pathophysiology of renal calcium handling in acromegaly: what lies behind hypercalciuria? J. Clin. Endocrinol. Metab. 97, 2124–2133 (2012)

    CAS  Article  PubMed  Google Scholar 

  10. J. Halupczok-Zyla, A. Jawiarczyk-Przybylowska, M. Bolanowski, Patients with active acromegaly are at high risk of 25(OH)D deficiency. Front. Endocrinol. (Lausanne) 6, 89 (2015)

    Google Scholar 

  11. A.J. Brown, D.W. Coyne, Bioavailable vitamin D in chronic kidney disease. Kidney Int. 82, 5–7 (2012)

    CAS  Article  PubMed  Google Scholar 

  12. J.B. Schwartz, J. Lai, B. Lizaola, L. Kane, S. Markova, P. Weyland, N.A. Terrault, N. Stotland, D. Bikle, A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J. Clin. Endocrinol. Metab. 99, 1631–1637 (2014)

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  13. D.D. Bikle, E. Gee, B. Halloran, M.A. Kowalski, E. Ryzen, J.G. Haddad, Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J. Clin. Endocrinol. Metab. 63, 954–959 (1986)

    CAS  Article  PubMed  Google Scholar 

  14. H.Q. Ying, H.L. Sun, B.S. He, Y.Q. Pan, F. Wang, Q.W. Deng, J. Chen, X. Liu, S.K. Wang, Circulating vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D and risk of colorectal cancer. Sci. Rep. 5, 7956 (2015)

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  15. L. Kane, K. Moore, D. Lutjohann, D. Bikle, J.B. Schwartz, Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. J. Clin. Endocrinol. Metab. 98, 4400–4409 (2013)

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  16. P. Glendenning, G.T. Chew, C.A. Inderjeeth, M. Taranto, W.D. Fraser, Calculated free and bioavailable vitamin D metabolite concentrations in vitamin D-deficient hip fracture patients after supplementation with cholecalciferol and ergocalciferol. Bone 56, 271–275 (2013)

    CAS  Article  PubMed  Google Scholar 

  17. A.P. Ashraf, C. Huisingh, J.A. Alvarez, X. Wang, B.A. Gower, Insulin resistance indices are inversely associated with vitamin D binding protein concentrations. J. Clin. Endocrinol. Metab. 99, 178–183 (2014)

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  18. R.F. Chun, B.E. Peercy, E.S. Orwoll, C.M. Nielson, J.S. Adams, M. Hewison, Vitamin D and DBP: the free hormone hypothesis revisited. J. Steroid Biochem. Mol. Biol. 144, 132–137 (2014)

    CAS  Article  PubMed  Google Scholar 

  19. M.S. Johnsen, G. Grimnes, Y. Figenschau, P.A. Torjesen, B. Almas, R. Jorde, Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D. Scand. J. Clin. Lab. Investig. 74, 177–183 (2014)

    CAS  Article  Google Scholar 

  20. C.E. Powe, C. Ricciardi, A.H. Berg, D. Erdenesanaa, G. Collerone, E. Ankers, J. Wenger, S.A. Karumanchi, R. Thadhani, I. Bhan, Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J. Bone Miner. Res. 26, 1609–1616 (2011)

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  21. A. Giustina, P. Chanson, M.D. Bronstein, A. Klibanski, S. Lamberts, F.F. Casanueva, P. Trainer, E. Ghigo, K. Ho, S. Melmed, A consensus on criteria for cure of acromegaly. J. Clin. Endocrinol. Metab. 95, 3141–3148 (2010)

    CAS  Article  PubMed  Google Scholar 

  22. L. Katznelson, J.L. Atkinson, D.M. Cook, S.Z. Ezzat, A.H. Hamrahian, K.K. Miller, American association of clinical endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly–2011 update: executive summary. Endocr. Pract. 17, 636–646 (2011)

    Article  PubMed  Google Scholar 

  23. American Diabetes Association, Classification and diagnosis of diabetes. Diabetes Care 38, S8–S16 (2015)

    Article  Google Scholar 

  24. P.A. James, S. Oparil, B.L. Carter, W.C. Cushman, C. Dennison-Himmelfarb, J. Handler, D.T. Lackland, M.L. LeFevre, T.D. MacKenzie, O. Ogedegbe, S.C. Smith Jr, L.P. Svetkey, S.J. Taler, R.R. Townsend, J.T. Wright Jr, A.S. Narva, E. Ortiz, 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 311, 507–520 (2014)

    CAS  Article  PubMed  Google Scholar 

  25. Third Report of the National Cholesterol Education Program (NCEP), Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult treatment panel III) final report. Circulation 106, 3143–3421 (2002)

    Google Scholar 

  26. M.M. Speeckaert, R. Speeckaert, N. van Geel, J.R. Delanghe, Vitamin D binding protein: a multifunctional protein of clinical importance. Adv. Clin. Chem. 63, 1–57 (2014)

    CAS  Article  PubMed  Google Scholar 

  27. R.F. Chun, New perspectives on the vitamin D binding protein. Cell Biochem. Funct. 30, 445–456 (2012)

    CAS  Article  PubMed  Google Scholar 

  28. P. Yousefzadeh, S.A. Shapses, X. Wang, Vitamin D binding protein impact on 25-hydroxyvitamin D levels under different physiologic and pathologic conditions. Int. J. Endocrinol. 2014, 981581 (2014)

    Article  PubMed  PubMed Central  Google Scholar 

  29. Z. Dastani, C. Berger, L. Langsetmo, L. Fu, B.Y. Wong, S. Malik, D. Goltzman, D.E. Cole, J.B. Richards, In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations. J. Bone Miner. Res. 29, 494–499 (2014)

    CAS  Article  PubMed  Google Scholar 

  30. J. Aloia, M. Mikhail, R. Dhaliwal, A. Shieh, G. Usera, A. Stolberg, L. Ragolia, S. Islam, Free 25(OH)D and the vitamin D paradox in African Americans. J. Clin. Endocrinol. Metab. 100, 3356–3363 (2015)

    CAS  Article  PubMed  Google Scholar 

  31. A. Vitezova, M.C. Zillikens, T.T. van Herpt, E.J. Sijbrands, A. Hofman, A.G. Uitterlinden, O.H. Franco, J.C. Kiefte-de Jong, Vitamin D status and metabolic syndrome in the elderly: the Rotterdam Study. Eur. J. Endocrinol. 172, 327–335 (2015)

    CAS  Article  PubMed  Google Scholar 

  32. A. Tsur, B.S. Feldman, I. Feldhammer, M.B. Hoshen, G. Leibowitz, R.D. Balicer, Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care 36, 1361–1367 (2013)

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  33. N.M. van Schoor, M. Visser, S.M. Pluijm, N. Kuchuk, J.H. Smit, P. Lips, Vitamin D deficiency as a risk factor for osteoporotic fractures. Bone 42, 260–266 (2008)

    Article  PubMed  Google Scholar 

  34. R. Shah, A. Licata, N.M. Oyesiku, A.G. Ioachimescu, Acromegaly as a cause of 1,25-dihydroxyvitamin D-dependent hypercalcemia: case reports and review of the literature. Pituitary 15(Suppl 1), S17–S22 (2012)

    Article  PubMed  Google Scholar 

  35. P. Ameri, A. Giusti, M. Boschetti, G. Murialdo, F. Minuto, D. Ferone, Interactions between vitamin D and IGF-I: from physiology to clinical practice. Clin. Endocrinol. (Oxf) 79, 457–463 (2013)

    CAS  Article  Google Scholar 

  36. A. Ajmal, A. Haghshenas, S. Attarian, M. Barake, N.A. Tritos, A. Klibanski, K.K. Miller, L.B. Nachtigall, The effect of somatostatin analogs on vitamin D and calcium concentrations in patients with acromegaly. Pituitary 17, 366–373 (2014)

    CAS  Article  PubMed  Google Scholar 

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Affiliations

  1. Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey

    Alev Eroglu Altinova, Cigdem Ozkan, Mujde Akturk, Muhittin Yalcin, Nuri Cakir & Fusun Balos Toruner

  2. Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey

    Ozlem Gulbahar

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  1. Alev Eroglu Altinova
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Correspondence to Cigdem Ozkan.

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Altinova, A.E., Ozkan, C., Akturk, M. et al. Vitamin D-binding protein and free vitamin D concentrations in acromegaly. Endocrine 52, 374–379 (2016). https://doi.org/10.1007/s12020-015-0789-1

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Keywords

  • Acromegaly
  • Vitamin D-binding protein
  • Total vitamin D
  • Free vitamin D