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Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis

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Abstract

The objective of the study is to assess the association between rs1801278 and rs2943641 of insulin receptor substrate 1 gene (IRS1) and the susceptibility to type 2 diabetes. A literature search strategy was conducted to identify all references lists of relevant studies. The fixed or random effect model was used to calculate the pooled ORs on the basis of heterogeneity. Further analyses were performed to explore the sources of heterogeneity by sensitivity analysis, meta-regression analysis, and subgroup analysis. There was significant association between rs1801278 and type 2 diabetes risk in recessive model (AA vs. GA + GG, p = 0.043) and codominant model (AA vs. GG, p = 0.007). Subgroup analysis showed that the association between rs1801278 and type 2 diabetes risk was significant in dominant model (GA + AA vs. GG, p = 0.044), codominant model (GA vs. GG, p = 0.039), codominant model (AA vs. GG, p = 0.044), overdominant model (GG + AA vs. GA, p = 0.037) in Asian and codominant model (AA vs. GG, p = 0.039) in Caucasian of rs1801278. The association between rs2943641 and type 2 diabetes risk was significant in codominant model (CT vs. CC, p = 0.023) in Caucasian. This meta-analysis suggests that rs1801278 may play a role in type 2 diabetes risk, especially in Asian. It also indicates that rs2943641 may be associated with type 2 diabetes risk in Caucasian. Further larger studies should be performed to warrant confirmation.

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Author Contribution

All authors have contributed to the paper. Li QY, Qiao YD, and Xu LD participated in the design of the study. Wang CT and Zhang GF assisted with data preparation. Zhang XL performed the statistical analysis. Li QY and Xu LD wrote the manuscript. All authors read and approved the final manuscript.

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This work was supported by grants from the National Natural Science Foundation of China (81102278), the China Postdoctoral Science Foundation (20100481019), the Postdoctoral Science Special Foundation of Heilongjiang Province, China (LBH-TZ1208), the Postdoctoral Science Research Foundation of Heilongjiang Province, China (LBH-Q13128), and Wu lien-teh Youth Science Foundation of Harbin Medical University (WLD-QN1405).

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    1. Laboratory of Medical Genetics, Harbin Medical University, Harbin, 150081, People’s Republic of China

      Qiuyan Li, Yuandong Qiao, Chuntao Wang, Guangfa Zhang, Xuelong Zhang & Lidan Xu

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    12020_2015_770_MOESM1_ESM.eps

    Forest plot for pooled ORs for the associations between codominant model (GA vs. GG) of rs1801278 and type 2 diabetes in the overall population (A), Caucasian (B), and Asian (C). Each square is proportional to the study-specific weight (EPS 3754 kb)

    12020_2015_770_MOESM2_ESM.eps

    Forest plot for pooled ORs for the associations between codominant model (AA vs. GG) of rs1801278 and type 2 diabetes in the overall population (A), Caucasian (B), and Asian (C). Each square is proportional to the study-specific weight (EPS 3534 kb)

    12020_2015_770_MOESM3_ESM.eps

    Forest plot for pooled ORs for the associations between overdominant model (GG + AA vs. GA) of rs1801278 and type 2 diabetes in the overall population (A), Caucasian (B), and Asian (C). Each square is proportional to the study-specific weight (EPS 4224 kb)

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    Li, Q., Qiao, Y., Wang, C. et al. Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis. Endocrine 51, 52–62 (2016). https://doi.org/10.1007/s12020-015-0770-z

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