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Endocrine

, Volume 49, Issue 3, pp 583–587 | Cite as

Does microbiota composition affect thyroid homeostasis?

  • Camilla Virili
  • Marco Centanni
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Abstract

The intestinal microbiota is essential for the host to ensure digestive and immunologic homeostasis. When microbiota homeostasis is impaired and dysbiosis occurs, the malfunction of epithelial barrier leads to intestinal and systemic disorders, chiefly immunologic and metabolic. The role of the intestinal tract is crucial in the metabolism of nutrients, drugs, and hormones, including exogenous and endogenous iodothyronines as well as micronutrients involved in thyroid homeostasis. However, the link between thyroid homeostasis and microbiota composition is not yet completely ascertained. A pathogenetic link with dysbiosis has been described in different autoimmune disorders but not yet fully elucidated in autoimmune thyroid disease which represents the most frequent of them. Anyway, it has been suggested that intestinal dysbiosis may trigger autoimmune thyroiditis. Furthermore, hypo- and hyper-thyroidism, often of autoimmune origin, were respectively associated to small intestinal bacterial overgrowth and to changes in microbiota composition. Whether some steps of this thyroid network may be affected by intestinal microbiota composition is briefly discussed below.

Keywords

Intestinal microbiota Selenium Thyroxine malabsorption Autoimmune thyroiditis Deiodinase Dysbiosis 
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Notes

Acknowledgments

This study has been supported by “Sapienza” University of Rome—(University Grants—prot.0006345).

Disclosure

The authors have nothing to disclose.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Endocrinology Section, Department of Medico-Surgical Sciences and Biotechnologies“Sapienza” University of RomeLatinaItaly
  2. 2.Endocrinology UnitAUSL LatinaLatinaItaly

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