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Aromatase enzyme expression in acromegaly and its possible relationship with disease prognosis

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Abstract

The purpose of this study was to evaluate aromatase enzyme expression in growth hormone (GH) secreting adenomas and comparison with prolactinomas, nonfunctional adenomas, and normal pituitary tissues. Also the impact of its expression on clinical and prognostic features was evaluated. 38 acromegaly, 26 prolactinoma, and 31 nonfunctional pituitary adenoma and 11 normal pituitary gland samples from autopsies were included. Aromatase and estrogen receptor-alpha (ERα) were evaluated by Immunohistochemical method; demographic, pre- and postoperative features of the patients were noted. Aromatase was expressed in varying degrees in all cases in study including controls. Aromatase expression in patients with acromegaly was significantly higher than patients with prolactinoma, nonfunctional adenoma, and controls (p = 0.04, p = 0.01 and p <0.001, respectively). Taken together two functional adenoma groups, prolactinoma and acromegaly, aromatase expression was negatively correlated with ER-alpha (p = 0.02, r = −0.34). Also, Ki-67 immunohistochemical results were negatively correlated with aromatase expression (p = 0.03, r = −0.27) while positively correlated with ER expression (p < 0.01). Consistent with the growing evidence about testosterone effect on pituitary functions, aromatase expression was found to be higher in GH-secreting pituitary adenoma. Aromatase was expressed in all pituitary tissues including autopsy samples; however, it was highest in patients with acromegaly. In patients with acromegaly and prolactinoma, aromatase expression was negatively correlated with Ki-67 score, and also it was higher in patients with complete postoperative remission than without remission. Therefore, aromatase expression may be a good prognostic marker predominantly in acromegaly.

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Acknowledgments

The study was supported by the Research Fund of the University, project no. 2013/37. This research was not supported by any specific grants from any funding agencies in the public, commercial, or not-for-profit sector. We thank Canan Baydemir of the Department of Biostatistics for her help with our statistical analyses.

Conflict of interest

The authors declare no conflicts of interest that could be perceived as prejudicing the impartiality of this research.

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Authors and Affiliations

  1. Department of Endocrinology and Methabolism, Faculty of Medicine, Kocaeli University, Kocaeli, 41380, Turkey

    Alev Selek, Berrin Cetinarslan, Ilhan Tarkun & Zeynep Canturk

  2. Department of Pathology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey

    Yesim Gurbuz

  3. Department of Neurosurgery, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey

    Burak Cabuk

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  1. Alev Selek
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Correspondence to Alev Selek.

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Selek, A., Cetinarslan, B., Gurbuz, Y. et al. Aromatase enzyme expression in acromegaly and its possible relationship with disease prognosis. Endocrine 49, 250–257 (2015). https://doi.org/10.1007/s12020-014-0445-1

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  • DOI: https://doi.org/10.1007/s12020-014-0445-1

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