, Volume 49, Issue 2, pp 549–552 | Cite as

Protective effects of coenzyme Q10 and aspartic acid on oxidative stress and DNA damage in subjects affected by idiopathic asthenozoospermia

  • Giacomo Tirabassi
  • Arianna Vignini
  • Luca Tiano
  • Eddi Buldreghini
  • Francesca Brugè
  • Sonia Silvestri
  • Patrick Orlando
  • Antimo D’Aniello
  • Laura Mazzanti
  • Andrea Lenzi
  • Giancarlo BalerciaEmail author
Research Letter


Male infertility is negatively influenced by reactive oxygen species and by other oxidant radicals [1]. In this regard, the relevant role of Coenzyme Q10 (CoQ10) in contributing to the total antioxidant buffer capacity of semen has been extensively investigated [1]. Two distinct studies conducted by our group, showed that in idiopathic asthenozoospermic patients undergoing CoQ10 therapy a significant increase in spermatozoa motility was observed [1, 2], suggesting its potential therapeutic role. On the other hand, Aspartic acid (d-Asp) supplementation was found to increase the concentration and motility of spermatozoa in oligo-asthenozoospermic and asthenozoospermic subjects [3]. Some evidence suggests a protective effect against oxidative stress for this molecule [4].

Only a few interventional studies have assessed oxidative stress in sperm of idiopathic infertile men treated with CoQ10 and d-Asp [5, 6, 7, 8, 9]. However, they just examined some of the markers of...


Nitric Oxide CoQ10 Sperm Cell Seminal Plasma Seminal Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



No external funding, apart from the support of the Polytechnic University of Marche, was available for this study. The authors wish to thank Dr. Anna Tangorra for skillful technical assistance.

Conflict of interest

The Authors have no conflict to disclose.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Giacomo Tirabassi
    • 1
  • Arianna Vignini
    • 2
  • Luca Tiano
    • 2
  • Eddi Buldreghini
    • 1
  • Francesca Brugè
    • 2
  • Sonia Silvestri
    • 2
  • Patrick Orlando
    • 2
  • Antimo D’Aniello
    • 3
  • Laura Mazzanti
    • 2
  • Andrea Lenzi
    • 4
  • Giancarlo Balercia
    • 1
    Email author
  1. 1.Division of Endocrinology, Department of Clinical and Molecular Sciences, School of Medicine, Umberto I HospitalPolytechnic University of MarcheAnconaItaly
  2. 2.Department of Odontostomatologic and Specialized Clinical SciencesPolytechnic University of MarcheAnconaItaly
  3. 3.Laboratory of BiochemistryADIPHARMNaplesItaly
  4. 4.Andrology, Pathophysiology of Reproduction and Endocrine Diagnosis Unit, Policlinic Umberto IUniversity of Rome ‘‘La Sapienza’’RomeItaly

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