Protective effects of coenzyme Q10 and aspartic acid on oxidative stress and DNA damage in subjects affected by idiopathic asthenozoospermia
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Male infertility is negatively influenced by reactive oxygen species and by other oxidant radicals . In this regard, the relevant role of Coenzyme Q10 (CoQ10) in contributing to the total antioxidant buffer capacity of semen has been extensively investigated . Two distinct studies conducted by our group, showed that in idiopathic asthenozoospermic patients undergoing CoQ10 therapy a significant increase in spermatozoa motility was observed [1, 2], suggesting its potential therapeutic role. On the other hand, Aspartic acid (d-Asp) supplementation was found to increase the concentration and motility of spermatozoa in oligo-asthenozoospermic and asthenozoospermic subjects . Some evidence suggests a protective effect against oxidative stress for this molecule .
Only a few interventional studies have assessed oxidative stress in sperm of idiopathic infertile men treated with CoQ10 and d-Asp [5, 6, 7, 8, 9]. However, they just examined some of the markers of...
KeywordsNitric Oxide CoQ10 Sperm Cell Seminal Plasma Seminal Fluid
No external funding, apart from the support of the Polytechnic University of Marche, was available for this study. The authors wish to thank Dr. Anna Tangorra for skillful technical assistance.
Conflict of interest
The Authors have no conflict to disclose.
- 1.G. Balercia, E. Buldreghini, A. Vignini, L. Tiano, F. Paggi, S. Amoroso, G. Ricciardo-Lamonica, M. Boscaro, A. Lenzi, G. Littarru, Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil. Steril. 91, 1785–1792 (2009)CrossRefPubMedGoogle Scholar
- 3.G. D’Aniello, S. Ronsini, T. Notari, N. Grieco, V. Infante, N. D’Angelo, F. Mascia, M.M. Di Fiore, G. Fisher, A. D’Aniello, d-aspartate, a key element for the improvement of sperm quality. Adv. Sex. Med. 2, 47–53 (2012)Google Scholar
- 4.Rathore, V.B. Gupta, Protective effect of amino acids on eye lenses against oxidative stress induced by hydrogen peroxide. Asian J. Pharm. Clin. Res. 3(3), 166–169 (2010)Google Scholar
- 5.R. Talevi, V. Barbato, I. Fiorentino, S. Braun, S. Longobardi, R. Gualtieri, Protective effects of in vitro treatment with zinc, d-aspartate and coenzyme q10 on human sperm motility, lipid peroxidation and DNA fragmentation. Reprod. Biol. Endocrinol. 11, 81 (2013)CrossRefPubMedCentralPubMedGoogle Scholar
- 6.A. Nadjarzadeh, M.R. Sadeghi, N. Amirjannati, M.R. Vafa, S.A. Motevalian, M.R. Gohari, M.A. Akhondi, P. Yavari, F. Shidfar, Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. J. Endocrinol. Invest. 34, e224–e228 (2011)PubMedGoogle Scholar
- 7.A. Nadjarzadeh, F. Shidfar, N. Amirjannati, M.R. Vafa, S.A. Motevalian, M.R. Gohari, S.A. Nazeri Kakhki, M.M. Akhondi, M.R. Sadeghi, Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia 46, 177–183 (2014)CrossRefPubMedGoogle Scholar
- 10.World Health Organization, WHO laboratory manual for the examination and processing of human semen, 5th edn. (World Health Organization, Geneva, 2010)Google Scholar