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H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight

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References

  1. M.S. Kramer, Determinants of low birth weight: methodological assessment and meta-analysis. WHO Bull. 65, 663–737 (1987)

    CAS  Google Scholar 

  2. W.W. Hay Jr, C.S. Catz, G.D. Grave, S.J. Yaffe, Workshop summary: fetal growth: its regulation and disorders. Pediatrics 99, 585–591 (1997)

    Article  PubMed  Google Scholar 

  3. M. Hack, H.G. Taylor, D. Drotar, M. Schluchter, L. Cartar, L. Andreias, D. Wilson-Costello, N. Klein, Chronic conditions, functional limitations, and special health care needs of school-aged children born with extremely low-birth-weight in the 1990s. JAMA 294(3), 318–325 (2005)

    Article  CAS  PubMed  Google Scholar 

  4. B. Clausson, P. Lichtenstein, S. Cnattingius, Genetic influence on birth weight and gestational length determined by studies in offspring of twins. BJOG 107, 375–381 (2000)

    Article  CAS  PubMed  Google Scholar 

  5. C.I. Brannan, E.C. Dees, R.S. Ingram, S.M. Tilghman, The product of the H19 gene may function as an RNA. Mol. Cell. Biol. 10, 28–36 (1990)

    PubMed Central  CAS  PubMed  Google Scholar 

  6. C.J. Petry, K.K. Ong, B.J. Barratt, D. Wingate, H.J. Cordell, S.M. Ring et al., Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans. BMC Genet. 6, 22 (2005)

    Article  PubMed Central  PubMed  Google Scholar 

  7. R.M. Adkins, G. Somes, J.C. Morrison, J.B. Hill, E.M. Watson, E.F. Magann et al., Association of birth weight with polymorphisms in the IGFII, H19 and IGF2R genes. Pediatr. Res. 68, 429–434 (2010)

    PubMed Central  CAS  PubMed  Google Scholar 

  8. J. Baker, J.P. Liu, A. Efstratiadis, Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75, 73–82 (1993)

    Article  CAS  PubMed  Google Scholar 

  9. P. Jayanthiny, K.H. Tennekoon, E.H. Karunanayake, J.M. Kumarasiri, A.P.D.S. Wijesundera, Di-Nucleotide repeat polymorphisms of the insulin like growth factor-1 gene and their association with IGF-1 insulin like growth factor-binding protein-1 and birth size in a Sri-Lankan cohort. Neonatology 100, 37–43 (2011)

    Article  CAS  PubMed  Google Scholar 

  10. C.J. Petry, R.V. Seear, D.L. Wingate, C.L. Acerini, K.K. Ong, I.A. Hughes et al., Maternally transmitted foetal H19 variants and association with birth weight. Hum. Genet. 130, 663–670 (2011)

    Article  PubMed  Google Scholar 

  11. A.L. Fowden, A.J. Forhead, Endocrine regulation of feto-placental growth. Horm. Res. 72, 257–265 (2009)

    Article  CAS  PubMed  Google Scholar 

  12. A.N. Sferruzzi-Perri, J.A. Owens, K.G. Pringle, C.T. Roberts, The neglected role of insulin-like growth factors in the maternal circulation regulating fetal growth. J. Physiol. 589, 7–20 (2011)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. W. Reik, M. Constancia, A. Fowden, N. Anderson, W. Dean, A. Ferguson-Smith, B. Tycko, C. Sible, Regulation of supply and demand for maternal nutrients in mammals by imprinted genes. J. Physiol. 547, 35–44 (2003)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. P.D. Gluckman, C.S. Pinal, Regulation of fetal growth by the somatotrophic axis. J. Nutr. 133, 1741–1745 (2003)

    Google Scholar 

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Acknowledgments

Supported by Sida/Secretariat for Research Cooperation (Grant for Molecular Biology and Biotechnology), National Research Council, Sri Lanka (Grant 05-28) and constitutes part of PhD studies of ASH.

Conflict of interest

All authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo 3, Sri Lanka

    A. S. Hewage, P. Jayanthiny, K. H. Tennekoon & E. H. Karunanayake

  2. Castle Street Hospital for Women, Colombo 8, Sri Lanka

    J. M. Kumarasiri & A. P. De S. Wijesundere

Authors
  1. A. S. Hewage
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  2. P. Jayanthiny
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  3. K. H. Tennekoon
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  4. J. M. Kumarasiri
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  5. A. P. De S. Wijesundere
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  6. E. H. Karunanayake
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Corresponding author

Correspondence to K. H. Tennekoon.

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Hewage, A.S., Jayanthiny, P., Tennekoon, K.H. et al. H19 rs217727 genotype and IGF-1/intron -2 dinucleotide CT repeat polymorphism are independently associated with birth weight. Endocrine 48, 1010–1012 (2015). https://doi.org/10.1007/s12020-014-0402-z

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  • DOI: https://doi.org/10.1007/s12020-014-0402-z

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