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Selenium supplementation and the risk of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

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An Erratum to this article was published on 24 February 2016

Abstract

It is well documented that selenium (Se) is involved in the metabolism of glucose. However, whether Se supplementation could lower the risk of type 2 diabetes mellitus (T2DM) remains elusive. We aimed to evaluate the association between Se supplementation and the risk of T2DM by performing a meta-analysis. We searched the Pubmed, Embase, and Cochrane databases from January 1990 to November 2013 to identify randomized controlled trials (RCTs) that met pre-stated inclusion criteria. Reference lists of retrieved articles were also reviewed. Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the pooled prevention effects. Four RCTs involving 20,294 participants were included in this meta-analysis. The combined relative risks (RRs) for subjects administered with Se compared with control groups were 1.09 (95 % CI: 0.99–1.20, p = 0.085). Omission of any single study did not change the overall risk estimates significantly. Meta- regression analyses showed almost no impact on the RRs of age and study length. No evidence of publication bias was observed. In conclusion, our findings do not support the routine application of Se supplementation for T2DM prevention in Caucasians. Larger studies are needed to investigate the effects of Se supplementation on T2DM prevention among various populations and further elucidate the impact of age and study length.

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References

  1. N. Jafari, Z. Farajzadegan, A. Loghmani, M. Majlesi, N. Jafari, Spiritual well-being and quality of life of Iranian adults with type 2 diabetes. Evid. Based Complement. Altern. Med. 2014, 619028 (2014)

    Article  Google Scholar 

  2. P. Zimmet, K.G. Alberti, J. Shaw, Global and societal implications of the diabetes epidemic. Nature 414, 782–787 (2001)

    Article  CAS  PubMed  Google Scholar 

  3. K. Imam, Management and treatment of diabetes mellitus. Adv. Exp. Med. Biol. 771, 356–380 (2012)

    PubMed  Google Scholar 

  4. A. Ceriello, E. Motz, Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler. Thromb. Vasc. Biol. 24, 816–823 (2004)

    Article  CAS  PubMed  Google Scholar 

  5. Y. Xia, K.E. Hill, D.W. Byrne, J. Xu, R.F. Burk, Effectiveness of selenium supplements in a low-selenium area of China. Am. J. Clin. Nutr. 81, 829–834 (2005)

    CAS  PubMed  Google Scholar 

  6. Z.W. Liu, H.T. Zhu, K.L. Chen, C. Qiu, K.F. Tang, X.L. Niu, Selenium attenuates high glucose-induced ROS/TLR-4 involved apoptosis of rat cardiomyocyte. Biol. Trace Elem. Res. 156, 262–270 (2013)

    Article  CAS  PubMed  Google Scholar 

  7. A.S. Müller, E. Most, J. Pallauf, Effects of a supranutritional dose of selenate compared with selenite on insulin sensitivity in type II diabetic dbdb mice. J. Anim. Physiol. Anim. Nutr. (Berl) 89, 94–104 (2005)

    Article  Google Scholar 

  8. J. Zhou, K. Huang, X.G. Lei, Selenium and diabetes—evidence from animal studies. Free Radic. Biol. Med. 584, 343–352 (2013)

    Google Scholar 

  9. M.S. Zeng, X. Li, Y. Liu, H. Zhao, J.C. Zhou, K. Li, J.Q. Huang, L.H. Sun, J.Y. Tang, X.J. Xia, K.N. Wang, X.G. Lei, A high-selenium diet induces insulin resistance in gestating rats and their offspring. Free Radic. Biol. Med. 52, 1335–1342 (2012)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. C. Kornhauser, J.R. Garcia-Ramirez, K. Wrobel, E.L. Pérez-Luque, M.E. Garay-Sevilla, K. Wrobel, Serum selenium and glutathione peroxidase concentrations in type 2 diabetes mellitus patients. Prim. Care Diabetes 2, 81–85 (2008)

    Article  PubMed  Google Scholar 

  11. S. Stranges, J.R. Marshall, R. Natarajan, R.P. Donahue, M. Trevisan, G.F. Combs, F.P. Cappuccio, A. Ceriello, M.E. Reid, Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann. Intern. Med. 147, 217–223 (2007)

    Article  PubMed  Google Scholar 

  12. H. Misu, T. Takamura, H. Takayama, H. Hayashi, N. Matsuzawa-Nagata, S. Kurita, K. Ishikura, H. Ando, Y. Takeshita, T. Ota, M. Sakurai, T. Yamashita, E. Mizukoshi, T. Yamashita, M. Honda, K. Miyamoto, T. Kubota, N. Kubota, T. Kadowaki, H.J. Kim, I.K. Lee, Y. Minokoshi, Y. Saito, K. Takahashi, Y. Yamada, N. Takakura, S. Kaneko, A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 12, 483–495 (2010)

    Article  CAS  PubMed  Google Scholar 

  13. A.M. Algotar, M.S. Stratton, S.P. Stratton, C.H. Hsu, F.R. Ahmann, No effect of selenium supplementation on serum glucose levels in men with prostate cancer. Am. J. Med. 123, 765–768 (2010)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. E.A. Klein, I.M. Thompson Jr, C.M. Tangen, J.J. Crowley, M.S. Lucia, P.J. Goodman, L.M. Minasian, L.G. Ford, H.L. Parnes, J.M. Gaziano, D.D. Karp, M.M. Lieber, P.J. Walther, L. Klotz, J.K. Parsons, J.L. Chin, A.K. Darke, S.M. Lippman, G.E. Goodman, F.L. Meyskens Jr, L.H. Baker, Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 306, 1549–1556 (2011)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. D.D. Karp, S.J. Lee, S.M. Keller, G.S. Wright, S. Aisner, S.A. Belinsky, D.H. Johnson, M.R. Johnston, G. Goodman, G. Clamon, G. Okawara, R. Marks, E. Frechette, W. McCaskill-Stevens, S.M. Lippman, J. Ruckdeschel, F.R. Khuri, Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597. J. Clin. Oncol. 31, 4179–4187 (2013)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. M.P. Rayman, S. Stranges, Epidemiology of selenium and type 2 diabetes: can we make sense of it? Free Radic. Biol. Med. 65, 1557–1564 (2013)

    Article  CAS  PubMed  Google Scholar 

  17. D. Moher, A. Liberati, J. Tetzlaff, D.G. Altman, PRISMA Group, preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int. J. Surg. 8, 336–341 (2010)

    Article  PubMed  Google Scholar 

  18. C.M. da Costa Santos, C.A. de Mattos Pimenta, M.R. Nobre, The PICO strategy for the research question construction and evidence search. Rev. Lat. Am. Enfermagem 15, 508–511 (2007)

    Article  PubMed  Google Scholar 

  19. L.V. Papp, A. Holmgren, K.K. Khanna, Selenium and selenoproteins in health and disease. Antioxid. Redox Signal. 12, 793–795 (2010)

    Article  CAS  PubMed  Google Scholar 

  20. S.R. Stapleton, Selenium: an insulin-mimetic. Cell. Mol. Life Sci. 57, 1874–1879 (2000)

    Article  CAS  PubMed  Google Scholar 

  21. H. Misu, T. Takamura, H. Takayama, H. Hayashi, N. Matsuzawa-Nagata, S. Kurita, K. Ishikura, H. Ando, Y. Takeshita, T. Ota, M. Sakurai, T. Yamashita, E. Mizukoshi, T. Yamashita, M. Honda, K. Miyamoto, T. Kubota, N. Kubota, T. Kadowaki, H.J. Kim, I.K. Lee, Y. Minokoshi, Y. Saito, K. Takahashi, Y. Yamada, N. Takakura, S. Kaneko, A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 12, 483–495 (2010)

    Article  CAS  PubMed  Google Scholar 

  22. T.N. Akbaraly, J. Arnaud, M.P. Rayman, I. Hininger-Favier, A.M. Roussel, C. Berr, A. Fontbonne, Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective Epidemiology of Vascular Ageing Study. Nutr. Metab. (Lond) 7, 21 (2010)

    Article  Google Scholar 

  23. X. Yan, M.P. Pepper, M.Z. Vatamaniuk, C.A. Roneker, L. Li, X.G. Lei, Dietary selenium deficiency partially rescues type 2 diabetes-like phenotypes of glutathione peroxidase-1- overexpressing male mice. J. Nutr. 142, 1975–1982 (2012)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  24. M.P. Rayman, G. Blundell-Pound, R. Pastor-Barriuso, E. Guallar, H. Steinbrenner, S. Stranges, A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin. PLoS One 7, e45269 (2012)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. X.M. Luo, H.J. Wei, C.L. Yang, J. Xing, X. Liu, C.H. Qiao, Y.M. Feng, J. Liu, Y.X. Liu, Q. Wu, Bioavailability of selenium to residents in a low-selenium area of China. Am. J. Clin. Nutr. 42, 439–448 (1985)

    CAS  PubMed  Google Scholar 

  26. Y. Xia, Y. Zhao, X. Zhao, L. Zhu, P.D. Whanger, Metabolism of selenate and selenomethionine by a selenium-deficient population of men in China. J. Nutr. 3, 202–210 (1992)

    CAS  Google Scholar 

  27. G. Forte, B. Bocca, A. Peruzzu, F. Tolu, Y. Asara, C. Farace, R. Oggiano, R. Madeddu, Blood metals concentration in type 1 and type 2 diabetics. Biol. Trace Elem. Res. 156, 79–90 (2013)

    Article  CAS  PubMed  Google Scholar 

  28. S. Praveena, S. Pasula, K. Sameera, Trace elements in diabetes mellitus. J. Clin. Diagn. Res. 7, 1863–1865 (2013)

    Google Scholar 

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Acknowledgments

This study was supported by Grants from the National Basic Research Program of China 973 Program (Nos. 2012CB517602 and 2013 CB 530604), the National Natural Science Foundation of China (Nos. 81170635 and 81270785) and the Research and innovation Project for College Graduates of Jiangsu Province, China (Grant number CXLX13_556).

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There is no conflict of interest for all authors.

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Authors and Affiliations

  1. Department of Nephrology, Nanjing Children’s Hospital, Affiliated to Nanjing Medical University, Nanjing, China

    Song Mao, Aihua Zhang & Songming Huang

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  1. Song Mao
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  2. Aihua Zhang
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Correspondence to Songming Huang.

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Mao, S., Zhang, A. & Huang, S. Selenium supplementation and the risk of type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Endocrine 47, 758–763 (2014). https://doi.org/10.1007/s12020-014-0298-7

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  • DOI: https://doi.org/10.1007/s12020-014-0298-7

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