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STEAP4 and insulin resistance

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Abstract

Obesity is a multifactorial disease that caused by the interactions between genetic susceptibility genes and environmental cues. Obesity is considered as a major risk factor of insulin resistance. STEAP4 is a novel anti-obesity gene that is significantly down-regulated in adipose tissue of obese patients. Over-expression of STEAP4 can improve glucose uptake and mitochondrial function, and increase insulin sensitivity. STEAP4 expression is regulated by a variety of inflammatory cytokines, hormones, or adipokines. In this review, we discuss function of STEAP4 in regulating insulin resistance in adipose tissue in vivo, as well as in adipocytes in vitro.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 31201811) and the Specific Research Supporting Program for Discipline Construction in Sichuan Agricultural University.

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  1. Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, 611130, Sichuan, People’s Republic of China

    Xiaoling Chen, Zhiqing Huang, Bo Zhou, Huan Wang, Gang Jia, Guangmang Liu & Hua Zhao

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  1. Xiaoling Chen
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Correspondence to Zhiqing Huang.

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Chen, X., Huang, Z., Zhou, B. et al. STEAP4 and insulin resistance. Endocrine 47, 372–379 (2014). https://doi.org/10.1007/s12020-014-0230-1

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