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Carotid intima-media thickness is not associated with vitamin D and PTH levels in patients admitted to an Internal Medicine Department

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Abstract

Vitamin D (25OHD) and/or parathyroid hormone (PTH) levels have been associated with common carotid intima-media thickness (IMT). We investigated such associations in inpatients consecutively admitted to an Internal Medicine Department. In 168 consecutive patients admitted to our department, 25 hydroxyvitamin D (25OHD) was measured by means of RIA and PTH by means of ICMA, whereas IMT by means of ultrasonography. The main cardiovascular risk factors were also explored. In patients with either diabetes, or hypertension, or both, 25OHD values were not significantly lower than in other patients. No difference was found among the IMT values across tertiles of 25OHD level, as like as in the 25OHD, PTH, PTH/25OHD ratio values of patients either grouped by tertiles of IMT, or categorized according to IMT of <0.9, 0.9–1.5, and >1.5 mm. IMT did not significantly associate with 25OHD, PTH, and PTH/25OHD ratio, whereas it positively associated with age (r = 0.281; p < 0.001) and BMI (r = 0.138; p = 0.074), and negatively with eGFR (r = −154; p = 0.046). Multiple regression models showed that IMT was significantly associated to age and BMI, while 25OHD, PTH, or PTH/25OHD ratio did not increase the significance of the models. IMT assessment does not seem to be associated with 25OHD and PTH levels in unselected inpatients.

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Acknowledgments

This research was partially granted by the by Ministry of Health of Italy (RF-2010-2320098) to A.S.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Unit of Internal Medicine, “Casa Sollievo della Sofferenza” Hospital, IRCCS, Viale dei Cappuccini snc, 71013, San Giovanni Rotondo, FG, Italy

    Vincenzo Carnevale, Rita Minonne, Angela De Matthaeis, Maria Antonietta Annese & Graziella D’Amico

  2. Unit of Nuclear Medicine, “Casa Sollievo della Sofferenza” Hospital, IRCCS, San Giovanni Rotondo, FG, Italy

    Patrizia Tabacco

  3. Unit of Clinical Chemistry, “Casa Sollievo della Sofferenza” Hospital, IRCCS, San Giovanni Rotondo, FG, Italy

    Palmina D’Arcangelo

  4. Unit of Endocrinology, “Casa Sollievo della Sofferenza” Hospital, IRCCS, San Giovanni Rotondo, FG, Italy

    Alfredo Scillitani

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  1. Vincenzo Carnevale
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Correspondence to Vincenzo Carnevale.

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Vincenzo Carnevale and Rita Minonne contributed equally to this study and share responsibility as first authors.

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Carnevale, V., Minonne, R., De Matthaeis, A. et al. Carotid intima-media thickness is not associated with vitamin D and PTH levels in patients admitted to an Internal Medicine Department. Endocrine 47, 833–838 (2014). https://doi.org/10.1007/s12020-014-0191-4

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  • DOI: https://doi.org/10.1007/s12020-014-0191-4

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