Skip to main content
SpringerLink
Log in

Maternal diabetes affects rat placental morphology and pregnancy

  • Research Letter
  • Published:
Endocrine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. A. Vambergue, I. Fajardy, Consequences of gestational and pregestational diabetes on placental function and birth weight. World J. Diabetes 2, 196–203 (2011)

    PubMed Central  PubMed  Google Scholar 

  2. Brazil Ministry of Health, High-risk Pregnancy: Technical Manual, 5th edn. (MS, Brasilia, 2010)

    Google Scholar 

  3. C.V. Howard, M.G. Reed, Unbiased Stereology: Three-Dimensional Measurements in Microscopy (Springer, New York, 1998)

    Google Scholar 

  4. T.M. Mayhew, Fetoplacental angiogenesis during gestation is biphasic, longitudinal and occurs by proliferation and remodelling of vascular endothelial cells. Placenta 23, 742–750 (2002)

    Article  PubMed  Google Scholar 

  5. P.M. Coan, A.C. Ferguson-Smith, G.J. Burton, Developmental dynamics of the definitive mouse placenta assessed by stereology. Biol. Reprod. 70, 1806–1813 (2004)

    Article  CAS  PubMed  Google Scholar 

  6. D.C. Damasceno, G.T. Volpato, I.M.P. Calderon, R.M.V. Cunha, Oxidative stress and diabetes in pregnant rats. Anim. Reprod. Sci. 72, 235–244 (2002)

    Article  CAS  PubMed  Google Scholar 

  7. I.L. Iessi, A. Bueno, Y.K. Sinzato, K.N. Taylor, M.V.C. Rudge, D.C. Damasceno, Evaluation of neonatally-induced mild diabetes in rats: maternal and fetal repercussions. Diabetol. Metab. Syndr. 2, 1–8 (2010)

    Article  Google Scholar 

  8. T.M.T. Zorn, M. Zúñiga, E. Madrid, R. Tostes, Z. Fortes, F. Giachini, S. San-Martín, Maternal diabetes affects cell proliferation in developing rat placenta. Histol. Histopathol. 26, 1049–1056 (2011)

    CAS  PubMed  Google Scholar 

  9. I. Sandovici, K. Hoelle, E. Angiolini, M. Constância, Placental adaptations to the maternal-fetal environment: implications for fetal growth and development programming. Reprod. Biomed. Online 25, 68–89 (2012)

    Article  PubMed  Google Scholar 

  10. M. Gauster, G. Desoye, M. Tötsch, U. Hiden, The placenta and gestational diabetes mellitus. Curr. Diab. Rep. 12, 16–23 (2012)

    Article  CAS  PubMed  Google Scholar 

  11. J.P. Canavan, D.F. Goldspink, Maternal diabetes in rats II. Effects on fetal growth and protein turnover. Diabetes 37, 1671–1677 (1988)

    Article  CAS  PubMed  Google Scholar 

  12. U.J. Eriksson, A. Andersson, S. Efendic, R. Elde, C. Hellersström, Diabetes in pregnancy: effects on the fetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatin. Acta Endocrinol. 94, 354–364 (1980)

    CAS  PubMed  Google Scholar 

  13. R. Padmanabhan, M. Shafiullah, Intrauterine growth retardation in experimental diabetes: possible role of the placenta. Arch. Physiol. Biochem. 109, 260–271 (2001)

    Article  CAS  PubMed  Google Scholar 

  14. I.H. Gewolb, W. Merdian, J.B. Warshaw, A.C. Enders, Fine structural abnormalities of the placenta in diabetic rats. Diabetes 35, 1254–1261 (1986)

    Article  CAS  PubMed  Google Scholar 

  15. R. Prager, A. Abramovici, E. Liban, Z. Laron, Histopathological changes in the placenta of streptozotocin induced diabetic rats. Diabetologia 10, 89–91 (1974)

    Article  CAS  PubMed  Google Scholar 

  16. Z. Néeman, V. Barash, E. Rosenmann, E. Shafrir, Localization of glycogen in the placenta of diabetic rats: a light and electron microscopic study. Placenta 8, 201–208 (1987)

    Article  Google Scholar 

  17. F.R. Giachini, V. Carriel, L.P. Capelo, R.C. Tostes, M.H. Carvalho, Z.B. Fortes, T.M. Zorn, S. San Martin, Maternal diabetes affects specific extracellular matrix components during placentation. J. Anat. 212, 31–41 (2008)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Y. Yu, U. Singh, W. Shi, T. Konno, M.J. Soares, R. Geyer, R. Fundele, Influence of murine maternal diabetes on placental morphology, gene expression, and function. Arch. Physiol. Biochem. 114, 99–110 (2008)

    Article  CAS  PubMed  Google Scholar 

  19. N. Acar, E.T. Korgun, I. Ustunel, Cell cycle inhibitor p57 expression in normal and diabetic rat placentas during some stages of pregnancy. Histol. Histopathol. 27, 59–68 (2012)

    CAS  PubMed  Google Scholar 

  20. A.L. Fowden, A.N. Sferruzzi-Perri, P.M. Coan, M. Constancia, G.J. Burton, Placental efficiency and adaptation: endocrine regulation. J. Physiol. 15, 3459–3472 (2009)

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported in part by CNPq and FAPITEC, Brazil.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Morphology, Federal University of Sergipe, Sao Cristovao, SE, Brazil

    Priscilla S. Farias, Karine dos S. Souza, Emerson T. Fioretto & Marlúcia B. Aires

  2. Department of Physiology, Federal University of Sergipe, Sao Cristovao, SE, Brazil

    Márcio R. V. dos Santos

Authors
  1. Priscilla S. Farias
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Karine dos S. Souza
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Emerson T. Fioretto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Márcio R. V. dos Santos
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Marlúcia B. Aires
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marlúcia B. Aires.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Farias, P.S., dos S. Souza, K., Fioretto, E.T. et al. Maternal diabetes affects rat placental morphology and pregnancy. Endocrine 45, 497–501 (2014). https://doi.org/10.1007/s12020-014-0169-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-014-0169-2

Keywords

Search

Navigation