New technologies aiding dietary programmes for weight control: the oral glucose spray
To determine whether the administration of small amounts of glucose through an oral spray device (GSD) facilitates weight loss in overweight/obese subjects involved in a lifestyle modification programme. We randomly assigned 56 overweight/obese subjects to either the treatment group (n = 32) or the control group (n = 24). All subjects in both groups followed a structured dietary programme of 6,280.2 kJ (1,500 kcal)/day and exercised minimum 150 min a week and were followed-up for a period of 60 days. Subjects assigned to the treatment group were asked to spray, during early symptoms of neuroglycopenia, 10 puffs by GSD. GSD is a device that delivers to the buccal mucosa 50 mg of glucose per puff. A mean weight loss of 3.5 ± 3.0 kg in GSD-treated group compared to 1.7 ± 2.1 kg in control group (p = 0.01) was observed. Significant differences regarding reduction of BMI (−1.3 ± 1.0 vs −0.7 ± 0.8 kg/m2; p = 0.01) and waist circumference (−3.5 ± 3.2 vs −0.9 ± 3.5 cm; p = 0.02) were also detected. A short-term use of GSD, in association with dietary restriction and exercise, is helpful in improving weight loss and in reducing waist circumference in overweight/obese subjects.
KeywordsObesity Weight loss Glucose spray Dietary programme
Conflict of interest
This study was supported by an educational grant to the University Campus Bio-Medico of Rome by Generex Biotechnology Inc. Generex Biotechnology Inc. gave us Glucose Rapid Spray for the trial. The sponsor had no role in the study design, data collection, data analysis or interpretation.
- 1.World Health Organization (WHO), Nutrition. Controlling the global obesity epidemic (2010), http://www.who.int. Accessed 15 Jan 2011
- 2.Trust for America’s Health, F as in fat: how obesity policies are failing in America (2010), http://healthyamericans.org/reports/obesity2007/. Accessed 20 Jan 2011
- 7.R.K. Johnson, L.J. Appel, M. Brands, B.V. Howard, M. Lefevre, R.H. Lustig, F. Sacks, L.M. Steffen, J. Wylie-Rosett, American Heart Association nutrition committee of the council on nutrition, physical activity, and metabolism and the council on epidemiology and prevention.: dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation 120, 1011–1020 (2009)PubMedCrossRefGoogle Scholar
- 11.W.D. McArdle, F.L. Katch, V.L. Katch, Essentials of exercise physiology (Lippincott, Williams & Wilkins, Baltimore, 2000)Google Scholar
- 13.L. Velázquez-López, E. González-Figueroa, P. Medina-Bravo, I. Pineda-Del Aquila, L. Avila-Jiménez, R. Ramos-Hernández, M. Klunder–Klunder, J. Escobedo-de la Peña, Low calorie and carbohydrate diet: to improve the cardiovascular risk indicators in overweight or obese adults with prediabetes. Endocrine (2012). doi: 10.1007/s12020-012-9775-z PubMedGoogle Scholar
- 14.P. Cryer, The prevention and correction of hypoglycemia, in Handbook of physiology, ed. by L. Jefferson, A. Cherrington, H. Goodman (Oxford University Press, New York, 2001), pp. 1057–1092Google Scholar
- 16.Y.M. Khazrai, F. Cacciapaglia, A. Picardi, G. Beretta Anguissola, C. Guglielmi, S. Manfrini, P. Pozzilli, Treatment of symptoms of neuroglycopenia with glucose RapidSprayTM to avoid rebound hyperglycaemia. Diabetes 57(suppl 1), A 564 (2008)Google Scholar