Abstract
Adiponectin is found to associate with diabetes in studies apart from cohort studies. This prospective cohort study is to evaluate the predictive role of adiponectin in diabetes among participants with impaired fasting glucose (IFG). A total of 42,845 participants who visited 7 health examination centers located in Seoul and Kyunggi province, South Korea, during 2004–2008 were first included. Of the 42,845 participants, 5,085 participants had IFG. IFG was categorized as stage 1 (fasting glucose 100–109 mg/dL) or stage 2 (110–125 mg/dL). The incidence rates of diabetes were followed up to December, 2011. Hazard ratios (HRs) and 95 % confidence intervals (CI) were performed by Cox proportional hazard model. Of the 5,085 participants, 652 participants developed diabetes during a mean follow-up of 4.4 years. Low adiponectin was associated with diabetes among men with stage 2 IFG (HR, 1.78; 95 %CI, 1.33–2.38) while it was associated with diabetes among women with stage 1 IFG (HR, 2.64; 95 %CI, 1.38–5.03) and stage 2 IFG (HR, 2.17; 95 %CI, 1.07–4.42). When combined men and women, the association between adiponectin and diabetes was statistically significant in stage 2 IFG with an increase of about 82 % (HR, 1.82; 95 %CI, 1.40–2.39) after adjusting for age, sex, body mass index, waist circumference, and fasting serum glucose. There was an interaction by sex and stage 1 IFG in the association between adiponectin and risk of diabetes (P < 0.001). Adiponectin was independently associated with diabetes among participants with IFG. This association was apparent in stage 2 IFG. Adiponectin may be used as a predictor of diabetes in patients having IFG.
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Abbreviations
- IFG:
-
Impaired fasting glucose
- IGT:
-
Impaired glucose tolerance
- BMI:
-
Body Mass Index
- HRs:
-
Hazard ratios
- CI:
-
95 % Confidence intervals
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Acknowledgments
This study was funded by the Seoul R&BD program (10526), the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (2011-0029348), a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family affairs, Republic of Korea (1220180).
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The authors have no conflict of interest related to this study.
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H.S.K. and S.H.J. drew the conception, researched the data, and wrote the manuscript. S.H.J. and J.J. analyzed data and edited the manuscript. L.J.E., T.Y.L., and H.K.B discussed and reviewed/edited the manuscript. Dr. Sun Ha Jee (S.H.J.) is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
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Kim, HS., Jo, J., Lim, J.E. et al. Adiponectin as predictor for diabetes among pre-diabetic groups. Endocrine 44, 411–418 (2013). https://doi.org/10.1007/s12020-013-9890-5
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DOI: https://doi.org/10.1007/s12020-013-9890-5