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Serum ischemic modified albumin levels might not be a marker of oxidative stress in patients with hypothyroidism

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Overt hypothyroidism and subclinical hypothyroidism are thought to be associated with atherosclerosis and a chronic ischemic process. Ischemic modified albumin (IMA) is a novel marker of ischemia. We examined serum IMA levels in patients with subclinical and overt hypothyroidism. We recruited patients who presented to our clinic for thyroid disease control. We compared demographic data, fasting blood sugar, serum lipid levels, and the prevalence of metabolic syndrome by the presence of overt, subclinical, and no hypothyroidism. Cobalt binding to albumin capacity was analyzed using a rapid colorimetric technique and compared among the groups. We assessed 11 men and 74 women with a mean age of 39.9 ± 12 years. Of these, 48 (56.5 %) were euthyroid, 24 (28.2 %) had subclinical hypothyroidism, and 13 (15.3 %) had overt hypothyroidism. The groups did not differ significantly in terms of age; body mass index; waist circumference; systolic and diastolic blood pressures; levels of fasting and nonfasting blood sugar, high- and low-density lipoproteins, and triglycerides; and the presence of metabolic syndrome. Mean serum IMA level also did not differ significantly among the groups: 0.20 ± 0.08 absorbance units (ABSU) in the euthyroid participants, 0.18 ± 0.08 ABSU in those with subclinical hypothyroidism, and 0.20 ± 0.09 ABSU in those with overt hypothyroidism (P = 0.754). Mean IMA values did not differ significantly by sex, cigarette use, the presence of metabolic syndrome, or the presence of thyroid autoantibodies. Serum IMA levels did not differ among patients with overt or subclinical hypothyroidism in this case-control study.

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  1. J.P. Almandoz, H. Gharib, Hypothyroidism: etiology, diagnosis, and management. Med. Clin. North Am. 96, 203–221 (2012)

    Article  PubMed  CAS  Google Scholar 

  2. A. Swaroop, T. Ramasarma, Heat exposure and hypothyroid conditions decrease hydrogen peroxide generation in liver mitochondria. Biochem. J. 226, 403–408 (1985)

    PubMed  CAS  Google Scholar 

  3. M.J. Coria, A.I. Pastrán, M.S. Gimenez, Serum oxidative stress parameters of women with hypothyroidism. Acta. Biomed. 80, 135–139 (2009)

    PubMed  Google Scholar 

  4. E. Sarandöl, S. Taş, M. Dirican, Z. Serdar, Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation. Cell Biochem. Funct. 23, 1–8 (2005)

    Article  PubMed  Google Scholar 

  5. D. Bar-Or, G. Curtis, N. Rao, N. Bampos, E. Lau E, Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia. Eur. J. Biochem. 268, 42–47 (2001)

    Article  PubMed  CAS  Google Scholar 

  6. D.C. Gaze, Ischemia modified albumin: a novel biomarker for the detection of cardiac ischemia. Drug Metab. Pharmacokinet. 24, 333–341 (2009)

    Article  PubMed  CAS  Google Scholar 

  7. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP), JAMA 285, 2486–2497 (2001)

  8. D. Bar-Or, E. Lau, J.V. Winkler, A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J. Emerg. Med. 19, 311–315 (2000)

    Article  PubMed  CAS  Google Scholar 

  9. S.G. Ma, Y. Jin, W. Xu, W.Hu, F. Bai, X.J. Wu, Increased serum levels of ischemia-modified albumin and C-reactive protein in type 1 diabetes patients with ketoacidosis. Endocrine (2012). doi:10.1007/s12020-012-9652-9

  10. K. Ukinc, S. Eminagaoglu, H.O. Ersoz, C. Erem, A.B. Hacıhasanoglu, M. Kocak, A novel indicator of wide spread endothelial damage and ischemia in diabetic patients: ischemia-modified albumin. Endocrine 36, 425–432 (2009)

    Article  PubMed  CAS  Google Scholar 

  11. S.G. Ma, C.L. Wei, B. Hong, W.N. Yu, Ischemia-modified albumin in type 2 diabetic patients with and without peripheral arterial disease. Clinics (Sao Paulo) 66, 1677–1680 (2011)

    Google Scholar 

  12. D. Chang, Q. Sha, X. Zhang, P. Liu, S. Rong, T. Han, P. Liu, H. Pan, The evaluation of the oxidative stress parameters in patients with primary angle-closure glaucoma. PLoS ONE 6, e27218 (2011)

    Article  PubMed  CAS  Google Scholar 

  13. A.E. Altınova, F.B. Törüner, M. Aktürk, N. Bukan, N. Cakır, G. Ayvaz, M. Arslan, Adipnectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidism. Metabolism 65, 1380–1383 (2006)

    Google Scholar 

  14. L. Tian, C. Gao, J. Liu, X. Zhang, Increased carotid arterial stiffness in subclinical hypothyroidism. Eur. J. Intern. Med. 21, 560–563 (2010)

    Article  PubMed  Google Scholar 

  15. F.A. Oner, S. Yurdakul, E. Oner, A.K. Uzum, M. Erguney, Evaluation of the effect of l-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism. Endocrine 66, 47–55 (2011)

    Google Scholar 

  16. V.N. Valentina, B. Marijan, D. Chedo, K. Branka, Subclinical hypothyroidism and risk to carotid atherosclerosis. Arq. Bras. Endocrinol. Metabol. 55, 475–480 (2011)

    Article  PubMed  Google Scholar 

  17. M. Mudau, A. Genis, A. Lochner, H. Strijdom, Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc. J. Afr. 23, 222–231 (2012)

    Article  PubMed  Google Scholar 

  18. S.G. Ma, L.X. Yang, F. Bai, W. Xu, B. Hong, Ischemia-modified albumin in patients with hyperthyroidism and hypothyroidism. Eur. J. Intern. Med. 23, e140–e316 (2012)

    Google Scholar 

  19. A. Oge, E. Sozmen, A.O. Karaoglu, Effect of thyroid function on LDL oxidation in hypothyroidism and hyperthyroidism. Endocr. Res. 30, 481–489 (2004)

    Article  PubMed  CAS  Google Scholar 

  20. P. Venditti, M. Balestrieri, S. Di Meo, T. De Leo, Effect of thyroid state on lipid peroxidation, antioxidant defences, and susceptibility to oxidative stress in rat tissues. J. Endocrinol. 155, 151–157 (1997)

    Article  PubMed  CAS  Google Scholar 

  21. C.A. Işman, B.C. Yeğen, I. Alican, Methimazole-induced hypothyroidism in rats ameliorates oxidative injury in experimental colitis. J. Endocrinol. 177, 471–476 (2003)

    Article  PubMed  Google Scholar 

  22. K.G. Moulakakis, M.V. Poulakou, T. Dosios, I. Dontas, D.P. Sokolis, I.S. Vlachos, M.C. Safioleas, A. Papachristodoulou, P.E. Karayannacos, D.N. Perrea, Hypothyroidism and the aorta. evidence of increased oxidative DNA damage to the aorta of hypothyroid rats. In Vivo 22, 603–608 (2008)

    PubMed  CAS  Google Scholar 

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English language editing of this manuscript was performed by Patricia French of Left Lane Communications (Chapel Hill, NC, USA) and funded by Sanofi-Aventis (İstanbul, Turkey).

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Correspondence to İnan Anaforoğlu.

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Ersoy, K., Anaforoğlu, İ. & Algün, E. Serum ischemic modified albumin levels might not be a marker of oxidative stress in patients with hypothyroidism. Endocrine 43, 430–433 (2013).

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