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The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women

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Abstract

To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in SPTBN1 gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P < 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P < 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.

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Acknowledgments

This study was supported by grants from the Chinese National Natural Science Foundation (81070693), Shanghai Education Committee Program (11ZZ101) and the Key Project of Shanghai Science and Technology (09DZ1950200).

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Authors and Affiliations

  1. Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic Division of Shanghai Universities E-Institutes, 197 Rui-jin Er Road, Shanghai, 200025, People’s Republic of China

    Yan-Hua Deng, Lin Zhao, Min-Jia Zhang, Hong-Yan Zhao, Li-Hao Sun, Bei Tao, Wei-Qing Wang, Guang Ning & Jian-Min Liu

  2. State Key Laboratory of Medical Genomics, Molecular Medicine Center, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, 197 Rui-jin Er Road, Shanghai, 200025, People’s Republic of China

    Chun-Ming Pan, Shuang-Xia Zhao & Huai-Dong Song

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  1. Yan-Hua Deng
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Correspondence to Jian-Min Liu.

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Yan-hua Deng and Lin Zhao contributed equally to this study.

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Deng, YH., Zhao, L., Zhang, MJ. et al. The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women. Endocrine 43, 127–135 (2013). https://doi.org/10.1007/s12020-012-9726-8

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