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Expression of cholecystokinin-1 receptor is correlated with proteinuria in human diabetic nephropathy

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Abstract

This study aimed to examine the expression of cholecystokinin-1 receptor (CCK-1R) in the kidneys of type 2 diabetic nephropathy (DN) and the correlation of CCK-1R mRNA and proteinuria. Localization of CCK-1R in kidney of diabetic patient with nephropathy was examined by immunohistochemistry and in situ hybridization. The glomeruli did not express CCK-1R in either control or diabetic nephropathic kidneys. However, the expressions of CCK-1R protein and mRNA in tubules were significantly increased in DN, which had no relationship with the severity of DN. Furthermore, there was a positive correlation between the percentage of cells positive for CCK-1R mRNA and the degree of proteinuria. Increased CCK-1R expression could be demonstrated in the tubules and the CCK-1R might be implicated in the development of proteinuria in human DN.

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China

    Mingao Wang, Rujuan Xie, Ruichan Liu, Xibei Jia & Yushi Bao

  2. Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China

    Xiaomin Liu

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  1. Mingao Wang
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  2. Rujuan Xie
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  3. Ruichan Liu
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  4. Xibei Jia
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Correspondence to Xiaomin Liu.

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Wang, M., Xie, R., Liu, R. et al. Expression of cholecystokinin-1 receptor is correlated with proteinuria in human diabetic nephropathy. Endocrine 42, 329–334 (2012). https://doi.org/10.1007/s12020-012-9630-2

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  • DOI: https://doi.org/10.1007/s12020-012-9630-2

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