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Increased high-density lipoprotein cholesterol is associated with a high prevalence of pre-hypertension and hypertension in community-dwelling persons

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Abstract

The aim of this article was that high-density lipoprotein cholesterol (HDL-C) reduces blood vessel injury through its antioxidant and anti-inflammatory functions. However, the effect of HDL-C on blood pressure may be controversial. Therefore, the aim of this study was to address whether HDL-C level is associated with blood pressure, and we examined cross-sectional data from community-dwelling persons. A total of 859 men [58 ± 15 (mean ± standard deviation); 20–89 (range) (years) and 1,169 women (61 ± 13; 19–88 years)] participants not on medication for hypertension were recruited from a single community at the time of their annual health examination. We examined the relationship between cardiovascular risk factors and blood pressure status. Multiple linear regression analysis using systolic blood pressure (SBP) and diastolic blood pressure (DBP) as an objective variable showed that HDL-C was significantly and independently associated with both SBP (β = 0.138), and DBP (β = 0.144). Compared to normotensive participants with the lowest quartile of HDL-C, multivariate-adjusted odds ratio (OR) for pre-hypertension was 1.72 (1.22–2.45) for the second quartile, 1.51 (1.07–2.15) for the third quartile, and 1.52 (1.04–2.22) for the highest quartile. Moreover, compared with normotensive participants with the lowest quartile, the multivariate-adjusted ORs for hypertension were 2.37 (1.63–3.45), 2.24 (1.54–3.28), 3.15 (2.10–4.74), respectively. There were no interactions between the two groups stratified by gender, age, BMI, drinking status, TG, FPG, and medication. Therefore, we concluded that HDL-C levels were positively associated with blood pressure in Japanese dwelling-community persons.

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Abbreviations

T-C:

Total cholesterol

TG:

Triglycerides

HDL-C:

High-density lipoprotein cholesterol

LDL-C:

Low-density lipoprotein cholesterol

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Acknowledgment

This study was supported in part by a grant-in-aid from the Foundation for Development of Community (2011).

Competing interests

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan

    Ryuichi Kawamoto, Masanori Abe & Tomo Kusunoki

  2. Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Ehime, Japan

    Yasuharu Tabara

  3. Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan

    Katsuhiko Kohara & Tetsuro Miki

  4. Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 9-53 Nomura, Nomura-cho, Seiyo-City, Ehime, 797-1212, Japan

    Ryuichi Kawamoto & Tomo Kusunoki

Authors
  1. Ryuichi Kawamoto
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  2. Yasuharu Tabara
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  3. Katsuhiko Kohara
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  4. Tetsuro Miki
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  5. Masanori Abe
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  6. Tomo Kusunoki
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Correspondence to Ryuichi Kawamoto.

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Author’s contributions

RK, YT, and KK participated in the design of the study, performed the statistical analysis and drafted the manuscript. TK contributed to the acquisition of data and its interpretation. MA contributed to the conception and design of the statistical analysis. TM conceived of the study, participated in its design, coordination and helped to draft the manuscript. All authors read and approved the manuscript.

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Kawamoto, R., Tabara, Y., Kohara, K. et al. Increased high-density lipoprotein cholesterol is associated with a high prevalence of pre-hypertension and hypertension in community-dwelling persons. Endocrine 42, 321–328 (2012). https://doi.org/10.1007/s12020-012-9625-z

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  • DOI: https://doi.org/10.1007/s12020-012-9625-z

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