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Evaluation of oxidative status in patients with hyperthyroidism

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Abstract

Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in this study. Serum oxidative status was determined via measurement of total antioxidant capacity (TAC) and total oxidant status (TOS) and calculation of oxidative stress index (OSI). Serum TAC levels were significantly lower in patients with hyperthyroidism than controls (P = 0.002), while serum TOS levels and OSI values were significantly higher (P = 0.008, 0.004; respectively). Serum TAC levels were correlated with TSH levels (rho = 0.223, P = 0.032), FT3 levels (rho = −0.434, P = 0.002) and FT4 levels (rho = −0.363, P = 0.003) in patients. Further, TOS levels and OSI values were correlated with TSH levels (rho = −0.245, P = 0.037; rho = −0.312, P = 0.011, respectively), FT3 levels (rho = 0.293, P = 0.017, rho = 0.505, P = 0.002, respectively), and FT4 levels (rho = 0.302, P = 0.006, rho = 0.321, P = 0.008, respectively) in patients. Duration of disease was significantly correlated with OSI values in patients (rho = 0.420, P = 0.011), while no correlation with serum TAC levels and TOS levels (P > 0.05). Oxidants are increased and antioxidants are decreased in patients with hyperthyroidism; as a result, the oxidative–antioxidative balance is shifted to the oxidative side. Increased oxidative stress may play a role in the pathogenesis of hyperthyroidism. It is believed that supplementation of antioxidant vitamins such as vitamins C and E may be helpful for these patients.

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Acknowledgments

The authors thank staffs of Harran University Clinical Biochemistry for their generous friendly assistance in every step of this study.

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Authors and Affiliations

  1. Medical Faculty, Department of Internal Medicine, Yuzuncu Yil University, Van, Turkey

    Mehmet Aslan, Ahmet Cumhur Dulger, Huseyin Begenik, Yasemin Usul Soyoral & Mehmet Emin Kucukoglu

  2. Medical Faculty, Department of Clinical Biochemistry, Harran University, Sanliurfa, Turkey

    Niyet Cosar, Nurten Aksoy & Sahbettin Selek

  3. Medical Faculty, Department of Physiology, Gaziantep University, Sanliurfa, Turkey

    Hakim Celik

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  1. Mehmet Aslan
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Correspondence to Mehmet Aslan.

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Aslan, M., Cosar, N., Celik, H. et al. Evaluation of oxidative status in patients with hyperthyroidism. Endocrine 40, 285–289 (2011). https://doi.org/10.1007/s12020-011-9472-3

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