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Leptin cut-off values for determination of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007)

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Abstract

Leptin is strongly contributed to the clustering of metabolic syndrome (MetS) components and potentially can be regarded as a single predictor of MetS. This population-based study, for the first time, reports the diagnostic accuracy of different leptin cut-points for determining MetS. Further, the current study compares the predictive ability of the appropriate threshold of leptin with insulin resistance. Data of the individuals without history of known diabetes mellitus, aged 25–64 years, from the third national surveillance of risk factors of non-communicable diseases (SuRFNCD-2007) were analyzed. MetS was defined due to either adult treatment panel III (ATPIII) or the modified international diabetes federation (IDF) criteria. Receiver-operating characteristic (ROC) curves were depicted to define cut-off of serum leptin, using the maximum Youden index and the shortest distance methods. Further, the values of leptin cut-offs in prediction of MetS were compared with those of insulin resistance (defined as homeostasis model assessment of insulin resistance >1.775). In men, the optimal cut-offs of leptin for IDF- and ATPIII-defined MetS were 3.6 ng/ml (positive predictive value, PPV: 56.5%; negative predictive value, NPV: 72.7%) and 4.1 ng/ml (PPV: 49.6%; NPV: 78.1%), respectively. In women, the optimal threshold was equal to 11.0 ng/ml (PPV: 53.8%; NPV: 73.0% for IDF criteria and PPV: 60.1%; NPV: 64.9% for ATPIII criteria). The diagnostic accuracy of these values in identifying MetS was similar to that of insulin resistance. Therefore, leptin is comparable to insulin resistance in identifying MetS and can be used as single predictor of MetS.

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Abbreviations

ATPIII:

Adult treatment panel III

AUC:

Area under the ROC curve

CDC:

Center for disease control

HDL-C:

High-density lipoprotein cholesterol

HOMA-IR:

Homeostasis model assessment of insulin resistance

IDF:

International diabetes federation

MetS:

Metabolic syndrome

NLR:

Negative likelihood ratio

NPV:

Negative predictive value

PLR:

Positive likelihood ratio

PPV:

Positive predictive value

ROC curve:

Receiver operating characteristics curve

SuRFNCD:

Surveillance of risk factors of non-communicable diseases

TG:

Triglycerides

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The authors declare no conflicts of interests.

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Authors and Affiliations

  1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran

    Alireza Esteghamati, Ali Zandieh, Basira Zandieh, Omid Khalilzadeh & Manouchehr Nakhjavani

  2. Department of Preventive Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Alipasha Meysamie

  3. Center for Disease Control, Ministry of Health and Medical Education, Tehran, Iran

    Mohammad Mehdi Gouya

Authors
  1. Alireza Esteghamati
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  2. Ali Zandieh
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  3. Basira Zandieh
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  4. Omid Khalilzadeh
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  6. Manouchehr Nakhjavani
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  7. Mohammad Mehdi Gouya
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Correspondence to Alireza Esteghamati.

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Esteghamati, A., Zandieh, A., Zandieh, B. et al. Leptin cut-off values for determination of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007). Endocrine 40, 117–123 (2011). https://doi.org/10.1007/s12020-011-9447-4

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  • DOI: https://doi.org/10.1007/s12020-011-9447-4

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