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Association of XIAP and P2X7 receptor expression with lymph node metastasis in papillary thyroid carcinoma

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Abstract

The expression of X-linked inhibitor of apoptosis (XIAP) and the P2X7 receptor were demonstrated in a variety of tumors. The purpose of the present study was to investigate the associations of XIAP and P2X7 receptor expression with the clinicopathological features of patients with papillary thyroid carcinoma (PTC). In this cross-sectional study, a total of 62 cases were examined, including 43 patients with PTCs and 19 with benign nodular goiters. XIAP and P2X7 receptor expression were examined by immunohistochemical methods on formalin-fixed, paraffin-embedded thyroid tissues. The staining intensity and extent were evaluated and scored using a semi-quantitative method. The immunohistochemical staining score integrating the intensity and extent of XIAP and P2X7 receptors in PTCs was higher than in nodular goiters. XIAP (OR: 5.6, 95% CI: 1.5–21.1, P = 0.009) and P2X7 receptor (OR: 6.1, 95% CI: 1.5–24.4, P = 0.007) expression were associated with lymph node metastasis in PTCs. In logistic regression analysis, P2X7 receptor expression, tumor size, and capsular infiltration were predictors for lymph node metastasis (P = 0.001). Our results suggested that XIAP and P2X7 receptor expression may predict the aggressiveness of PTC.

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Acknowledgment

This study was supported by Grant 09XJ21070 from Shanghai Jiao-tong University School of Medicine.

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Authors and Affiliations

  1. Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center For Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, 197 Rui-jin Er Road, Shanghai, 200025, People’s Republic of China

    Li-Qun Gu, Feng-Ying Li, Lin Zhao, Yun Liu, Jian-Min Liu, Guang Ning & Yong-Ju Zhao

  2. Department of Pathology, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, People’s Republic of China

    Qian Chu

  3. Department of Endocrinology, Le-qing People’s Hospital, Leqing, Zhejiang Province, People’s Republic of China

    Xun-Xiong Zang

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  1. Li-Qun Gu
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Gu, LQ., Li, FY., Zhao, L. et al. Association of XIAP and P2X7 receptor expression with lymph node metastasis in papillary thyroid carcinoma. Endocr 38, 276–282 (2010). https://doi.org/10.1007/s12020-010-9384-7

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  • DOI: https://doi.org/10.1007/s12020-010-9384-7

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