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Clustering of leptin and physical activity with components of metabolic syndrome in Iranian population: an exploratory factor analysis

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Abstract

Metabolic syndrome (MetS), manifested by insulin resistance, dyslipidemia, central obesity, and hypertension, is conceived to be associated with hyperleptinemia and physical activity. The aim of this study was to elucidate the factors underlying components of MetS and also to test the suitability of leptin and physical activity as additional components of this syndrome. Data of the individuals without history of diabetes mellitus, aged 25–64 years, from third national surveillance of risk factors of non-communicable diseases (SuRFNCD-2007), were analyzed. Performing factor analysis on waist circumference, homeostasis model assessment of insulin resistance, systolic blood pressure, triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) led to extraction of two factors which explained around 59.0% of the total variance in both genders. When TG and HDL-C were replaced by TG to HDL-C ratio, a single factor was obtained. In contrast to physical activity, addition of leptin was consistent with one-factor structure of MetS and improved the ability of suggested models to identify obesity (BMI ≥ 30 kg/m2, P < 0.01), using receiver-operator characteristics curve analysis. In general, physical activity loaded on the first identified factor. Our study shows that one underlying factor structure of MetS is also plausible and the inclusion of leptin does not interfere with this structure. Further, this study suggests that physical activity influences MetS components via modulation of the main underlying pathophysiologic pathway of this syndrome.

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Abbreviations

BMI:

Body mass index

CDC:

Center for disease control

GPAQ:

Global physical activity questionnaire

HDL-C:

High-density lipoprotein cholesterol

HOMA-IR:

Homeostasis model assessment of insulin resistance

LDL-C:

Low-density lipoprotein cholesterol

MET:

Metabolic equivalent

MetS:

Metabolic syndrome

SuRFNCD-2007:

Third national surveillance of risk factors of non-communicable diseases conducted in 2007

SBP:

Systolic blood pressure

TG:

Triglycerides

TG/HDL-C:

Triglycerides to high-density lipoprotein cholesterol

TPA:

Total physical activity

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Conflict of interest statement

The authors declare no conflicts of interests.

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Authors and Affiliations

  1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran

    Alireza Esteghamati, Ali Zandieh, Omid Khalilzadeh, Afsaneh Morteza & Manouchehr Nakhjavani

  2. Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Alipasha Meysamie

  3. Center for Disease Control, Ministry of Health and Medical Education, Tehran, Iran

    Mohammad Mehdi Gouya

Authors
  1. Alireza Esteghamati
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  2. Ali Zandieh
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  3. Omid Khalilzadeh
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  4. Afsaneh Morteza
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  5. Alipasha Meysamie
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  6. Manouchehr Nakhjavani
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  7. Mohammad Mehdi Gouya
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Correspondence to Alireza Esteghamati.

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Esteghamati, A., Zandieh, A., Khalilzadeh, O. et al. Clustering of leptin and physical activity with components of metabolic syndrome in Iranian population: an exploratory factor analysis. Endocr 38, 206–213 (2010). https://doi.org/10.1007/s12020-010-9374-9

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  • DOI: https://doi.org/10.1007/s12020-010-9374-9

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