Skip to main content

The association between vitamin D status and circulating adiponectin independent of adiposity in subjects with abnormal glucose tolerance

Abstract

Vitamin D status assessed by serum 25-hydroxyvitamin D levels (25(OH)D) has been shown to be inversely associated with insulin resistance. The underlying basis for such association is less clear. In the present study, we assessed the prevalence of inadequate vitamin D levels and its relationship to glucose tolerance status and circulating adiponectin in healthy Thai population. The cohort of 246 subjects was classified into two groups according to 75 g oral glucose tolerance test (OGTT) results. There were 86 subjects and 160 subjects in normal glucose tolerance group (NGT) and abnormal glucose tolerance group (AGT), respectively. Anthropometric variables were recorded for each individual. Fasting blood samples were assayed for 25(OH)D, adiponectin, glucose, and insulin levels. Insulin resistance (HOMA-IR) and insulin secretion index (HOMA-B) were calculated by the homeostasis model assessment. Pearson and partial correlation analyses were performed. There were 35 males and 211 females with a mean age of 62.4 ± 7.2 years in this study. The mean levels of 25(OH)D were 21.4 ± 6.6 ng/ml. The prevalence of vitamin D deficiency defined by 25(OH)D levels less than 20 ng/ml and vitamin D inadequacy defined by 25(OH)D levels less than 30 ng/ml were 44.3 and 91.9%, respectively. The mean levels of 25(OH)D obtained from samples collected in the rainy season (19.4 ± 4.6 ng/ml) were significantly lower than those collected in the winter (22.6 ± 8.3 ng/ml) and summer period (23.1 ± 4.6 ng/ml). AGT subjects had slightly lower average 25(OH)D levels than the NGT group (21.0 ± 6.8 vs. 22.1 ± 6.2 ng/ml, P = 0.09). 25(OH)D levels were positively associated with adiponectin levels (r = 0.20, P < 0.05) and negatively associated with HOMA-IR and BMI (r = −0.22, P < 0.01 and r = −0.22, P < 0.01, respectively) only in AGT subjects. An independent association between 25(OH)D and adiponectin levels was demonstrated after controlling for BMI (r = 0.17, P < 0.05). High prevalence of vitamin D inadequacy and seasonal variation of vitamin D status are found in Thai population. We demonstrated an association between insufficient vitamin D status and lower circulating adiponectin in subjects with abnormal glucose tolerance independently of adiposity which may indicate the role of adiponectin as a link between vitamin D status and insulin resistance.

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. M.F. Holick, N. Engl. J. Med. 357, 266–281 (2007)

    CAS  Article  PubMed  Google Scholar 

  2. M.F. Holick, E.S. Siris, N. Binkley, M.K. Beard, A. Khan, J.T. Katzer, R.A. Petruschke, E. Chen, A.E. de Papp, J. Clin. Endocrinol. Metab. 90, 3215–3224 (2005)

    CAS  Article  PubMed  Google Scholar 

  3. M.K. Thomas, D.M. Lloyd-Jones, R.I. Thadhani, A.C. Shaw, D.J. Deraska, B.T. Kitch, E.C. Vamvakas, I.M. Dick, R.L. Prince, J.S. Finkelstein, N. Engl. J. Med. 338, 777–783 (1998)

    CAS  Article  PubMed  Google Scholar 

  4. M.C. Chapuy, P. Preziosi, M. Maamer, S. Arnaud, P. Galan, S. Hercberg, P.J. Meunier, Osteoporos. Int. 7, 439–443 (1997)

    CAS  Article  PubMed  Google Scholar 

  5. R.P. Heaney, M.S. Dowell, C.A. Hale, A. Bendich, J. Am. Coll. Nutr. 22, 142–146 (2003)

    CAS  PubMed  Google Scholar 

  6. B. Dawson-Hughes, R.P. Heaney, M.F. Holick, P. Lips, P.J. Meunier, R. Vieth, Osteoporos. Int. 16, 713–716 (2005)

    CAS  Article  PubMed  Google Scholar 

  7. S.K. Lim, A.W. Kung, S. Sompongse, S. Soontrapa, K.S. Tsai, Curr. Med. Res. Opin. 24, 99–106 (2008)

    CAS  Article  PubMed  Google Scholar 

  8. C. Mattila, P. Knekt, S. Mannisto, H. Rissanen, M.A. Laaksonen, J. Montonen, A. Reunanen, Diabetes Care 30, 2569–2570 (2007)

    CAS  Article  PubMed  Google Scholar 

  9. W.B. Grant, Prog. Biophys. Mol. Biol. 92, 65–79 (2006)

    CAS  Article  PubMed  Google Scholar 

  10. A.G. Pittas, J. Lau, F.B. Hu, B. Dawson-Hughes, J. Clin. Endocrinol. Metab. 92, 2017–2029 (2007)

    CAS  Article  PubMed  Google Scholar 

  11. K.C. Chiu, A. Chu, V.L. Go, M.F. Saad, Am. J. Clin. Nutr. 79, 820–825 (2004)

    CAS  PubMed  Google Scholar 

  12. T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, K. Tobe, J. Clin. Invest. 116, 1784–1792 (2006)

    CAS  Article  PubMed  Google Scholar 

  13. M. Daimon, T. Oizumi, T. Saitoh, W. Kameda, A. Hirata, H. Yamaguchi, H. Ohnuma, M. Igarashi, M. Tominaga, T. Kato, Diabetes Care 26, 2015–2020 (2003)

    CAS  Article  PubMed  Google Scholar 

  14. A. Malabanan, I.E. Veronikis, M.F. Holick, Lancet 351, 805–806 (1998)

    CAS  Article  PubMed  Google Scholar 

  15. V. Tangpricha, E.N. Pearce, T.C. Chen, M.F. Holick, Am. J. Med. 112, 659–662 (2002)

    CAS  Article  PubMed  Google Scholar 

  16. M.F. Holick, Mayo Clin. Proc. 81, 353–373 (2006)

    CAS  Article  PubMed  Google Scholar 

  17. S. Soontrapa, C. Pongchaiyakul, C. Somboonporn, W. Somboonporn, L.O. Chailurkit, J. Med. Assoc. Thai. 84(Suppl 2), S534–S541 (2001)

    PubMed  Google Scholar 

  18. D. Warodomwichit, R. Leelawattana, N. Luanseng, N. Thammakumpee, J. Med. Assoc. Thai. 85, 990–997 (2002)

    PubMed  Google Scholar 

  19. S. Soontrapa, L.O. Chailurkit, J. Med. Assoc. Thai. 88(Suppl 5), S17–S20 (2005)

    PubMed  Google Scholar 

  20. K. Nakamura, M. Nashimoto, M. Yamamoto, Int. J. Biometeorol. 44, 186–189 (2000)

    CAS  Article  PubMed  Google Scholar 

  21. K.S. Tsai, S.H. Hsu, J.P. Cheng, R.S. Yang, Bone 20, 371–374 (1997)

    CAS  Article  PubMed  Google Scholar 

  22. J.H. Kim, S.J. Moon, Int. J. Food Sci. Nutr. 51, 439–451 (2000)

    CAS  Article  PubMed  Google Scholar 

  23. R. Scragg, M. Sowers, C. Bell, Diabetes Care 27, 2813–2818 (2004)

    CAS  Article  PubMed  Google Scholar 

  24. A.M. Borissova, T. Tankova, G. Kirilov, L. Dakovska, R. Kovacheva, Int. J. Clin. Pract. 57, 258–261 (2003)

    CAS  PubMed  Google Scholar 

  25. L. Lind, A. Hanni, H. Lithell, A. Hvarfner, O.H. Sorensen, S. Ljunghall, Am. J. Hypertens. 8, 894–901 (1995)

    CAS  Article  PubMed  Google Scholar 

  26. E. Orwoll, M. Riddle, M. Prince, Am. J. Clin. Nutr. 59, 1083–1087 (1994)

    CAS  PubMed  Google Scholar 

  27. E. Liu, J.B. Meigs, A.G. Pittas, N.M. McKeown, C.D. Economos, S.L. Booth, P.F. Jacques, J. Nutr. 139, 329–334 (2009)

    CAS  PubMed  Google Scholar 

  28. M.H. Gannage-Yared, R. Chedid, S. Khalife, E. Azzi, F. Zoghbi, G. Halaby, Eur. J. Endocrinol. 160, 965–971 (2009)

    CAS  Article  PubMed  Google Scholar 

  29. L. Carvallo, B. Henriquez, J. Olate, A.J. van Wijnen, J.B. Lian, G.S. Stein, S. Onate, J.L. Stein, M. Montecino, J. Steroid Biochem. Mol. Biol. 103, 420–424 (2007)

    CAS  Article  PubMed  Google Scholar 

  30. N.K. Lee, H. Sowa, E. Hinoi, M. Ferron, J.D. Ahn, C. Confavreux, R. Dacquin, P.J. Mee, M.D. McKee, D.Y. Jung, Z. Zhang, J.K. Kim, F. Mauvais-Jarvis, P. Ducy, G. Karsenty, Cell 130, 456–469 (2007)

    CAS  Article  PubMed  Google Scholar 

  31. G. Wolf, Nutr. Rev. 66, 229–233 (2008)

    Article  PubMed  Google Scholar 

  32. P. Pietschmann, G. Schernthaner, W. Woloszczuk, Diabetologia 31, 892–895 (1988)

    CAS  Article  PubMed  Google Scholar 

  33. H. Dobnig, J.C. Piswanger-Solkner, M. Roth, B. Obermayer-Pietsch, A. Tiran, A. Strele, E. Maier, P. Maritschnegg, C. Sieberer, A. Fahrleitner-Pammer, J. Clin. Endocrinol. Metab. 91, 3355–3363 (2006)

    CAS  Article  PubMed  Google Scholar 

  34. M.T. Rosato, S.H. Schneider, S.A. Shapses, Calcif. Tissue Int. 63, 107–111 (1998)

    CAS  Article  PubMed  Google Scholar 

  35. S. Sayinalp, O. Gedik, Z. Koray, Calcif. Tissue Int. 57, 422–425 (1995)

    CAS  Article  PubMed  Google Scholar 

  36. R.J. Wood, Nutr. Rev. 66, 40–46 (2008)

    Article  PubMed  Google Scholar 

  37. Diabetes Care 20, 1183–1197 (1997)

Download references

Acknowledgment

This study was supported by The Thailand Research Fund.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hataikarn Nimitphong.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nimitphong, H., Chanprasertyothin, S., Jongjaroenprasert, W. et al. The association between vitamin D status and circulating adiponectin independent of adiposity in subjects with abnormal glucose tolerance. Endocr 36, 205–210 (2009). https://doi.org/10.1007/s12020-009-9216-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-009-9216-9

Keywords

  • Vitamin D
  • Adiponectin
  • Insulin resistance
  • Abnormal glucose tolerance