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Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants

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Abstract

Previous studies have suggested that ENPP1, INSIG2, and PLIN may be linked with a higher risk for obesity or with increased phenotypic measures of obesity. We selected polymorphisms in these candidate genes based on their prior associations with obesity risk or obesity parameters. K121Q (rs1044498) in ENPP1, rs7566605 in INSIG2, and rs894160 in PLIN were genotyped by Taqman assays in a Belgian sample of 1,078 obese subjects (body mass index (BMI) > 30 kg/m2) and 323 lean controls (18.5 < BMI < 25 kg/m2). BMI, waist circumference, and waist-to-hip ratio (WHR) were assessed by standard methods while a computerized tomography-scan was used to measure visceral (VFA), subcutaneous (SFA), and total (TFA) abdominal fat areas. Presence of the rare allele was not significantly different between cases and controls for the three variants that were tested, while only WHR was associated with ENPP1 in obese subjects. Our data thus indicate that K121Q, rs7566605, and rs894160 are not major contributing factors for obesity.

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Acknowledgments

We thank J. Vertommen, M. Vinckx, and P. Aerts for sampling handling. Financial support to this study was provided by the University of Antwerp (NOI-BOF grant) and the Fund for Scientific Research (FWO) Flanders (research project) both to LVG and WVH. SB holds a predoctoral research grant from the Instituut voor de aanmoediging van innovatie door Wetenschap en Technologie (IWT) in Vlaanderen. The authors do not report any conflict of interest with respect to this article.

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Authors and Affiliations

  1. Center for Medical Genetics, Department of Biomedical Sciences, University of Antwerp (UA) and Antwerp University Hospital, Universiteitsplein 1, Wilrijk, 2610, Antwerp, Belgium

    Armand Peeters, Sigri Beckers & Wim Van Hul

  2. Department of Endocrinology, Diabetology and Metabolism, University of Antwerp (UA) and Antwerp University Hospital, Antwerp, Belgium

    An Verrijken, Ilse Mertens & Luc Van Gaal

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  1. Armand Peeters
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Correspondence to Armand Peeters.

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Armand Peeters and Sigri Beckers contributed equally to this work.

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Peeters, A., Beckers, S., Verrijken, A. et al. Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants. Endocr 36, 103–109 (2009). https://doi.org/10.1007/s12020-009-9194-y

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