Abstract
The main objective of this article is to study the psychosocial profile of patients of Cushing disease (CD) in a developing country setting. Eighteen patients with CD underwent a cross-sectional assessment regarding their socio-demographic and clinical profile, life events, social support, coping, dysfunction, quality of life, and psychiatric morbidity. Twenty-two demographically group-matched healthy participants (free from psychological morbidity) acted as the control group. The CD group had predominance of females (71.5%) with mean age at onset of 20.38 (range 8–38) years, and mean duration of illness of 65.33 (range 4–260) months. Six subjects (i.e., GHQ positive group) scored positive on the General Health Questionnaire-12 giving a psychological morbidity rate of 33.33%, with one having an ICD-10 diagnosis. There was no difference between GHQ positive and GHQ negative groups on number of life events, social support, quality of life and dysfunction. However, GHQ positive group used significantly more of internalizing coping strategies. Psychological morbidity occurs in a significant percentage of patients with CD. Presence of psychological morbidity is associated with internalizing coping strategies.
References
C. Tsigos, G.P. Chrousos, Ann. Rev Med. 47, 443–461 (1996)
J.A. Yanovski, G.B. Cutler Jr., Endocrinol. Metab. Clin. North Am. 23, 487–509 (1994)
P.M. Gotch, Endocrinol Metab. Clin. North Am. 23, 607–617 (1994)
M. Starkman, D. Schteingart, Arch. Intern. Med. 141, 215–219 (1981)
L. Pikkarainen, T. Sane, A. Reunanen, J Internal Med. 245, 463–468 (1999)
M. Mauri, E. Sinoforiani, G. Bono, F. Vignati, M.E. Berselli, R. Attanasio et al., Acta Neurol. Scand. 87, 52–55 (1993)
L.D. Dorn, E.S. Burgess, B. Dubbert, S.E. Simpson, T. Friedman, M. Kling, P.W. Gold, G.P. Chrousos, Clin Endocrinol. 43, 433–442 (1995)
R.G. Kathol, J.W. Delahunt, L. Hannah, J. Clin. Psychiatry 46, 194–196 (1985)
D. Hirsch, G. Orr, V. Kantarovich, H. Hermesh, E. Stern, I. Blum, Isr. J. Psychiatry Relat. Sci. 37, 46–50 (2000)
H.M. Burke, L.C. Fernald, P.J. Gertler, N.E. Adler, Psychosom. Med. 67, 211–216 (2005)
D.E. Polk, S. Cohen, W.J. Doyle, D.P. Skoner, C. Kirschbaum, Psychoneuroendocrinology 30, 261–272 (2005)
J.W. Stewart, F.M. Quitkin, P.J. McGrath, D.F. Klein, J. Affect Disord. 86, 161–167 (2005)
M.O. van Aken, A.M. Pereira, N.R. Biermasz, S.W. van Thiel, H.C. Hoftijzer, J.W. Smit et al., J. Clin. Endocrinol. Metab. 90, 3279–3286 (2005)
Y. Sharma, S.K. Mattoo, P. Kulhara, S.C. Sharma, P. Sharan, German J. Psychiatry 6, 40–48 (2003)
D. Pershad, S.K. Verma, S. Malhotra, A. Malhotra, Measurement of Dysfunction and Dysfunction Analysis Questionnaire (National Psychological Corporation, Agra, 1985)
S. Saxena, K. Chandramani, R. Bhargava, Natl. Med. J. Ind. 11, 160–166 (1998)
S.M. Skevington, M. Lotfy, K.A. O’Connell, WHOQOL Group, A report from the WHOQOL group. Qual. Life Res. 13, 299–310 (2004)
C.L. Cooper, E.B. Faragher, Psychol. Med. 22, 447–455 (1992)
G. Singh, D. Kour, H. Kour, Ind. J. Psychiatry 26, 107–114 (1984)
T.H. Holmes, R.H. Rahe, J. Psychosom. Res. 11, 213–218 (1967)
R. Nehra, P. Kulhara, S.K. Verma, Ind. J. Clin. Psychol. 23, 33–39 (1996)
L. Pollock, R. Harris, Psychol. Rep. 53, 446 (1983)
S.K. Chaturvedi, G. Singh, N. Gupta, Dermatol. Clin. 23, 635–642 (2005)
D. Goldberg, The Detection of Psychiatric Illness by Questionnaire, Maudsley Monograph No. 21 (Oxford University Press, London, 1972)
S. Gautam, M. Nijhawan, P. Kamal, Ind. J. Psychiatry 29, 63–66 (1987)
K.S. Jacob, D. Bhugra, A.H. Mann, Ind. J. Psychiatry 39, 196–199 (1997)
S.K. Mattoo, S. Handa, I. Kaur, N. Gupta, R. Malhotra, J. Dermatol. 28, 424–432 (2001)
S.K. Mattoo, S. Handa, I. Kaur, N. Gupta, R. Malhotra, J. Eur. Acad. Dermatol. Venereol. 16, 573–578 (2002)
S.K. Mattoo, S. Handa, I. Kaur, N. Gupta, R. Malhotra, German J. Psychiatry 8, 17–22 (2005)
A. Cano, R.P. Sprafkin, D.J. Scaturo, L.J. Lantinga, B.H. Fiese, F. Brand, Prim. Care Companion J. Clin. Psychiatry 3, 206–210 (2001)
M. Åsberg, S.A. Montgomery, C. Perris, D. Schalling, G. Sedvall, Acta Psychiatr. Scand. 271(Suppl), 5–28 (1978)
E.W. Martinsen, S. Friis, A. Hoffait, Acta Psychiatr. Scand. 80, 492–498 (1989)
S.A. Montgomery, M. Åsberg, Br. J. Psychiatry. 134, 382–389 (1979)
World Health Organization, The International Classification of Diseases-10th revision (World Health Organization, Geneva, 1992)
A. Mahal, A.S. Yazbeck, D.H. Peters, G.N.V. Ramana, The International Bank for Reconstruction and Development (The World Bank, Washington, DC, 2001)
S. Gifford, J.G. Gunderson, Medicine 49, 397–409 (1970)
S.I. Cohen, Br. J. Psychiatry 136, 20–124 (1980)
N. Sonino, G.A. Fava, S. Grandi, F. Mantero, M. Boscaro, Clin. Endocrinol. (Oxf) 29, 617–623 (1988)
N. Sonino, G.A. Fava, M. Boscaro, Clin. Endocrinol. (Oxf) 38, 261–264 (1993)
E.S. Paykel, Psychol. Med. 27, 301–310 (1997)
M.T. Hawn, D. Cook, C. Deveney, B.C. Sheppard, Surgery 132, 1064–1068 (2002)
S.K. Nagesser, A.P. van Seters, J. Kievit, J. Hermans, H.M. Krans, C.J. van de Velde, World J. Surg. 24, 108–113 (2000)
J. Lindholm, S. Juul, J.O. Jorgensen, J. Astrup, P. Bjerre, U. Feldt-Rasmussen et al., J. Clin. Endocrinol. Metab. 86, 117–123 (2001)
R.F. Haskett, Am. J. Psychiatry 142, 911–916 (1985)
F.A. Whitlock, Symptomatic Affective Disorders (Academic Press, Sydney, 1982)
J.I. Hudson, M.S. Hudson, G.T. Griffing, J.C. Melby, H.G. Pope, Am. J. Psychiatry 144, 951–953 (1987)
O.M. Wolkowitz, V.I. Reus, T. Chan, F. Manfredi, W. Raum, R. Johnson, J. Canick, Biol. Psychiatry 45, 1070–1074 (1999)
N. Sonino, G.A. Fava, Prog. Neuropsychopharmacol. Biol. Psychiatry 26, 1011–1018 (2002)
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The Research was funded by a Research Grant from the Postgraduate Institute of Medical Education and Research, Chandigarh.
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Mattoo, S.K., Bhansali, A.K., Gupta, N. et al. Psychosocial morbidity in Cushing disease: a study from India. Endocr 35, 306–311 (2009). https://doi.org/10.1007/s12020-009-9182-2
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DOI: https://doi.org/10.1007/s12020-009-9182-2