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Circulating adiponectin represents a biomarker of the association between adiposity and bone mineral density

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Abstract

An association exists between adiposity, insulin resistance, and osteoporosis; however, the mechanism of this relationship remains enigmatic. We aimed to determine whether the insulin resistance index (HOMA-IR), serum adiponectin, or leptin levels are associated with bone mineral density (BMD). A cross-sectional, observational study was designed. Eighty-four postmenopausal ambulant women [52.5 (50.0–58.0) years; body mass index (BMI): 29.4 (25.9–33.8) kg/m2] referred for osteoporosis screening were enrolled. Anthropometric measures, fasting serum adiponectin and leptin levels, and the HOMA-IR were determined. The relationships between these variables and lumbar, hip, and forearm BMD measured by dual-energy X-ray absorptiometry (DXA) were analyzed. Considering all 84 participants, the HOMA-IR index was 1.82 (1.17–2.86), serum adiponectin was 13.25 (10.49–16.88) μg/ml, and serum leptin was 19.26 (14.94–24.90) ng/ml. BMI, waist circumference, and leptin positively correlated with hip and lumbar BMD, whereas adiponectin negatively correlated. Multivariate analysis confirmed an inverse relation between serum adiponectin level and femoral neck and lumbar BMD measurements. In total hip and forearm areas, there was no independent association of adipocytokines with BMD measurements. Instead, waist circumference was independently associated with BMD measurements. In conclusion, adiponectin may represent a biomarker in the relationship between visceral fat mass and BMD. However, this association is probably confounded by the specific body composition parameters (i.e., waist circumference, BMI) in postmenopausal women.

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Acknowledgments

The authors have no conflict of interest. This research did not receive any specific grant from any funding agency in the public, or commercial sector. We wish to thank Havva Oğuz and Metin Ödevci for their support in the laboratory.

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Authors and Affiliations

  1. Department of Internal Medicine, Endocrinology and Metabolism Unit, Ankara University Faculty of Medicine, Sıhhiye, Ankara, 06100, Turkey

    Kemal Ağbaht

  2. Department of Internal Medicine, Endocrinology and Metabolism Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Alper Gürlek & Miyase Bayraktar

  3. Department of Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Jale Karakaya

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  1. Kemal Ağbaht
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  2. Alper Gürlek
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Correspondence to Kemal Ağbaht.

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Ağbaht, K., Gürlek, A., Karakaya, J. et al. Circulating adiponectin represents a biomarker of the association between adiposity and bone mineral density. Endocr 35, 371–379 (2009). https://doi.org/10.1007/s12020-009-9158-2

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  • DOI: https://doi.org/10.1007/s12020-009-9158-2

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