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Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy

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Abstract

Matrix metalloproteinases (MMPs), a family of proteinases including collagenases, gelatinases, stromelysins, matrilysins, and membrane-type MMPs, affect the breakdown and turnover of extracellular matrix (ECM). Moreover, they are major physiologic determinants of ECM degradation and turnover in the glomerulus. Renal hypertrophy and abnormal ECM deposition are hallmarks of diabetic nephropathy (DN), suggesting that altered MMP expression or activation contributes to renal injury in DN. Herein, we review and summarize recent information supporting a role for MMPs in the pathogenesis of DN. Specifically, studies describing dysregulated activity of MMPs and/or their tissue inhibitors in various experimental models of diabetes, including animal models of type 1 or type 2 diabetes, clinical investigations of human type 1 or type 2 diabetes, and kidney cell culture studies are reviewed.

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Acknowledgments

This work was supported in part by grants from the National Institutes of Health to KMT (R01-DK62999) and from the Arkansas Children’s Hospital Research Institute CUMG Award Program to KMT (#036054).

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Authors and Affiliations

  1. Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital Research Institute, 800 Marshall Street, Slot 512-6, AR 72202, Little Rock, USA

    Kathryn M. Thrailkill, R. Clay Bunn & John L. Fowlkes

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  1. Kathryn M. Thrailkill
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  2. R. Clay Bunn
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  3. John L. Fowlkes
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Correspondence to Kathryn M. Thrailkill.

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Thrailkill, K.M., Clay Bunn, R. & Fowlkes, J.L. Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy. Endocr 35, 1–10 (2009). https://doi.org/10.1007/s12020-008-9114-6

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  • DOI: https://doi.org/10.1007/s12020-008-9114-6

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