Skip to main content

Advertisement

Log in

Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences

  • Original Paper
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Brain-derived neurotrophic factor (BDNF) has emerged as a new element related with insulin resistance and obesity. Objective To evaluate the effect of a 3-month reduced-calorie diet (RCD) on serum BDNF concentrations in overweight and obese subjects. Subjects Seventeen healthy overweight and obese subjects of both sexes (24–48 years, BMI 34.6 ± 1.1 kg/m2). Methods Anthropometry, oral glucose tolerance test (OGTT), lipid levels, and serum BDNF were measured at baseline and at the end of the third month. Reduced-calorie diet was defined as a 25% reduction in energy intake composed of: 55% carbohydrates, 20% proteins, and 25% fat (less than 10% saturated fat and over 10% nonsaturated fat). Refined sugar was not allowed. Results There was a significant decrease in BMI, waist circumference, body fat percentage, fasting glucose, post-OGTT glucose levels, area under the curve of glucose, and HOMA2-IR after 3 months of RCD. Serum BDNF showed a significant increase (3.97 ± 0.87 to 6.75 ± 1.62 ng/ml, P = 0.02). Final serum BDNF correlated negatively with weight (r = −0.51, P = 0.03), and basal post-OGTT insulin correlated positively with final serum BDNF (r = 0.48, P = 0.04). Conclusions Serum BDNF increases in insulin-resistant overweight and obese subjects after three months on a RCD. This observation could indicate that BDNF may be modulated in humans through diet composition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. R. Katoh-Semba, I.K. Takeuchi, R. Semba, K. Kato, J. Neurochem. 69, 34–42 (1997)

    Article  CAS  PubMed  Google Scholar 

  2. Q. Yan, M.J. Radeke, C.R. Matheson, J. Talvenheimo, A.A. Welcher, S.C. Feinstein, J. Comp. Neurol. 378, 135–157 (1997)

    Article  CAS  PubMed  Google Scholar 

  3. B.J. Xu, E.H. Goulding, K.L. Zang, D. Cepoi, R.D. Cone, K.R. Jones, K.R. Jones, L.H. Tecota, L.F. Reichardt, Nat. Neurosci. 6, 736–742 (2003)

    Article  CAS  PubMed  Google Scholar 

  4. S.G. Kernie, D.J. Liebl, L.F. Parada, EMBO J. 19, 1290–1300 (2000)

    Article  CAS  PubMed  Google Scholar 

  5. M. Rios, G. Fan, C. Fekete, J. Kelly, B. Bates, R. Kuehn, R.M. Lechan, R. Jaenisch, Mol. Endocrinol. 15, 1748–1757 (2001)

    Article  CAS  PubMed  Google Scholar 

  6. E.A. Fox, M.S. Byerly, Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R994–1004 (2004)

    CAS  PubMed  Google Scholar 

  7. J. Tonra, M. Ono, X. Liu, K. Garcia, C. Jackson, G. Yancopoulos, S. Wiegand, V. Wong, Diabetes 48, 588–594 (1999)

    Article  CAS  PubMed  Google Scholar 

  8. M. Ono, Y. Itakura, T. Nonomura, T. Nakagawa, Ch. Nakayama, M. Taiji, H. Noguchi, Metabolism 49, 129–133 (2000)

    Article  CAS  PubMed  Google Scholar 

  9. T. Nakagawa, M. Ono-Kishino, E. Sugaru, M. Yamanaka, M. Taiji, H. Noguchi, Diabetes Metab. Res. Rev. 18, 185–191 (2002)

    Article  CAS  PubMed  Google Scholar 

  10. T. Nakagawa, Y. Ogawa, K. Ebihara, M. Yamanaka, A. Tsuchida, M. Taiji, H. Noguchi, Int. J. Obes. Relat. Metab. Disord. 27, 557–565 (2003)

    Article  CAS  PubMed  Google Scholar 

  11. A. Tsuchida, T. Nonomura, T. Nakagawa, Y. Itakura, M. Ono-Kishino, M. Yamanaka, E. Sugaru, M. Taiji, H. Noguchi, Diabetes Obes. Metab. 4, 262–269 (2002)

    Article  CAS  PubMed  Google Scholar 

  12. G.N. Chaldakov, M. Fiore, I.S. Stankulov, L. Manni, M.G. Hristova, A. Antonelli, P.I. Ghenev, L. Aloe, Prog. Brain Res. 146, 279–289 (2004)

    Article  CAS  PubMed  Google Scholar 

  13. A.H. El-Gharbawy, D.C. Adler-Wailes, M.C. Mirch, K.R. Theim, L. Ranzenhofer, M. Tanofsky-Kraff, J. Clin. Endocrinol. Metab. 91, 3548–3552 (2006)

    Article  CAS  PubMed  Google Scholar 

  14. M. Lommatzsch, D. Zingler, K. Schuhbaeck, K. Schloetcke, C. Zingler, P. Schuff-Werner, J.C. Virchow, Neurobiol. Aging 26, 115–123 (2005)

    Article  CAS  PubMed  Google Scholar 

  15. K.S. Krabbe, A.R. Nielsen, R.K. Madsen, P. Plomgaard, P. Rasmussen, C. Erikstrup, C.P. Fischer, B. Lindegaard, A. Petersen, S. Taudorf, N.H. Secher, H. Pilegaard, H. Bruunsgaard, B.K. Pedersen, Diabetologia 50, 431–438 (2007)

    Article  CAS  PubMed  Google Scholar 

  16. M. Suwa, H. Kishimoto, Y. Nofuji, H. Nakano, H. Sasaki, Z. Radak, S. Kumagai, Metab. Clin. Exp. 55, 852–857 (2006)

    CAS  PubMed  Google Scholar 

  17. R. Molteni, R. Barnard, Z. Ying, C. Roberts, F. Gómez-Pinilla, Neuroscience 112, 803–814 (2002)

    Article  CAS  PubMed  Google Scholar 

  18. W. Duan, J. Lee, Z. Guo, M.P. Mattson, J. Mol. Neurosci. 16, 1–12 (2001)

    Article  CAS  PubMed  Google Scholar 

  19. W. Duan, Z. Guo, H. Jiang, M. Ware, M.P. Mattson, Endocrinology 144, 2446–2453 (2003)

    Article  CAS  PubMed  Google Scholar 

  20. M.P. Mattson, W. Duan, R. Wan, Z. Guo, NeuroRx 1, 111–116 (2004)

    Article  PubMed  Google Scholar 

  21. N. Maswood, J. Young, E. Tilmont, Z. Zhang, D.M. Gash, G.A. Gerhardt, G.S. Roth, J. Mattison, M.A. Lane, R.E. Carson, R.M. Cohen, P.R. Mouton, C. Quigley, M.P. Mattson, D.K. Ingram, Proc. Natl. Acad. Sci. USA 101, 18171–18176 (2004)

    Article  CAS  PubMed  Google Scholar 

  22. B. Martin, M. Pearson, L. Kebejian, E. Golden, A. Keselman, M. Bender, O. Carlson, J. Egan, B. Ladenheim, J.L. Cadet, K.G. Becker, W. Wood, K. Duffy, P. Vinayakumar, S. Maudsley, M.P. Mattson, Endocrinology 148, 4318–4333 (2007)

    Article  CAS  PubMed  Google Scholar 

  23. K.A. Varady, D.J. Roohk, Y.C. Loe, B.K. McEvoy-Hein, M.K. Hellerstein, J. Lipid Res. 48, 2112–2219 (2007)

    Article  Google Scholar 

  24. P. Monteleone, A. Tortorella, V. Martiadis, C. Serritella, A. Fuschino, M. Maj, Psychosom. Med. 66, 744–748 (2004)

    Article  CAS  PubMed  Google Scholar 

  25. T. Nakahashi, H. Fujimura, C.A. Altar, J. Li, J. Kambayashi, N.N. Tandon, B. Sun, FEBS Lett. 470, 113–117 (2000)

    Article  CAS  PubMed  Google Scholar 

  26. M.J. Donovan, R.C. Miranda, R. Kraemer, T.A. McCaffrey, L. Tessarolo, D. Mahadeo, S. Sharif, D.R. Kaplan, P. Tsoulfas, L. Parada, D. Toran-Allerand, D.P. Hajjar, B.L. Hempstead, Am. J. Pathol. 147, 309–324 (1995)

    CAS  PubMed  Google Scholar 

  27. P. Fernyhough, L.T. Diemel, W.J. Brewster, D.R. Tomlinson, J. Neurochem. 64, 1231–1237 (1995)

    Article  CAS  PubMed  Google Scholar 

  28. S.J. Miknyoczki, D. Lang, L. Huang, A.J. Klein-Szanto, C.A. Dionne, B.A. Ruggeri, Int. J. Cancer 81, 417–427 (1999)

    Article  CAS  PubMed  Google Scholar 

  29. E. Shimizu, K. Hashimoto, M. Iyo, Am. J. Med. Genet. B Neuropsychiatr. Genet. 126, 122–123 (2004)

    Article  Google Scholar 

  30. J.V. Durnin, J. Womersley, Br. J. Nutr. 32, 77–97 (1974)

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Supported by Grant 107/05 from the Oficina de Apoyo a la Investigación Clínica (OAIC) of the University of Chile Clinical Hospital. We would like to thank Mrs. Carolina Bienzobas for evaluating the Beck Depression Inventory, Mr. Alvaro Reyes for his expert statistical advice, and Dr. Lorena Ferreira MD whose accurate reading and comments of the English manuscript were essential for its publication.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Veronica Araya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Araya, A.V., Orellana, X. & Espinoza, J. Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences. Endocr 33, 300–304 (2008). https://doi.org/10.1007/s12020-008-9090-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-008-9090-x

Keywords

Navigation