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Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves’ disease in Chinese patients

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Abstract

Objective

In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves’ disease (GD) and the susceptibility of K469E polymorphism to Graves’ ophthalmopathy (GO) in Chinese population.

Study Design

A case-control and replication study was performed in 212 GD patients and 204 healthy subjects to analyze the genotypes. Furthermore the distribution of ICAM-1 genotypes was investigated in subgroups of patients with GD according to the onset age and the ophthalmopathy.

Results

No G241R polymorphism of ICAM-1 gene was detected in Chinese. No significant differences of allele and genotype frequencies regarding K469E polymorphism were found between GD patients and healthy controls (χ2 = 0.092, P = 0.762; χ2 = 1.089, P = 0.580). In addition, the genotype–phenotype correlation was not identified either.

Conclusions

We found no association of G241R and K469E polymorphisms of the ICAM-1gene with the development of GD in a Chinese population. However, we could not rule out possible contributions of other polymorphisms of the ICAM-1gene to the pathogenesis of GD. Therefore, further studies are needed to elucidate the role of ICAM-1gene in Graves’ disease in different population.

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Acknowledgment

The present study would not have been possible without the participation of the patients and healthy volunteers. This research was supported by grants from National Natural Science Foundation of China (No. 30370666) and the E-Institute of Shanghai Universities (No. E03007)

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Authors and Affiliations

  1. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P.R. China

    Shu Wang, Hua Sun, Hao-Yan Chen, Ze-Fei Zhao, Yang Yang, Yong-Ju Zhao & Guang Ning

  2. Laboratory of Endocrine & Metabolic Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences/Shanghai JiaoTong University School of Medicine, Chinese Academy of Sciences, 225 South ChongQing Road, Shanghai, 200025, P.R. China

    Shu Wang, Hao-Yan Chen, Bin Cui & Guang Ning

  3. Division of Endocrine and Metabolic Diseases of E-Institute of Shanghai Universities, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P.R. China

    Shu Wang, Hua Sun, Hao-Yan Chen, Ze-Fei Zhao, Yang Yang, Yong-Ju Zhao & Guang Ning

Authors
  1. Shu Wang
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  2. Hua Sun
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  3. Hao-Yan Chen
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  8. Guang Ning
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Corresponding author

Correspondence to Guang Ning.

Additional information

Shu Wang and Hua Sun contributed equally to this work.

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Wang, S., Sun, H., Chen, HY. et al. Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves’ disease in Chinese patients. Endocr 31, 114–118 (2007). https://doi.org/10.1007/s12020-007-0032-9

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  • DOI: https://doi.org/10.1007/s12020-007-0032-9

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