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Erectile dysfunction in the cardiac patient

  • Original Article
  • Published:
Comprehensive Therapy

Abstract

Erectile dysfunction (ED) is a common problem in men over 40–50 years of age. Risk factors include: diabetes, lipid abnormalities, smoking, hypertension, obesity, and lack of physical activity. Oral phosphodiesterase-5 inhibitors appear effective and safe in most cardiac patients.

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References

  1. NIH Consensus Development Panel on Impotence. Impotence: NIH Consensus Conference JAMA. 1993:270:83–90.

    Article  Google Scholar 

  2. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994:151:54–61.

    PubMed  CAS  Google Scholar 

  3. Virag R, Bouilly P, Frydman D. Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men. Lancet. 1985;332:181–4

    Article  Google Scholar 

  4. Feldman HA, Johannes CB, Derby CA, et al. Erectile dysfunction and coronary risk factors: Prospective results from the Massachusetts Male Aging Study. Prevent Med. 2000;30:328–38.

    Article  CAS  Google Scholar 

  5. Levine LA. Erectile dysfunction causes, diagnosis and treatment. Compr Ther. 1989;15:54–8.

    PubMed  CAS  Google Scholar 

  6. Burchardt M, Burchardt T, Baer L, et al. Hypertension is associated with severe erectile dysfunction. J Urol. 2000;164:1188–91.

    Article  PubMed  CAS  Google Scholar 

  7. Treasure CB, Klein JL, Weintraub WS, et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med. 1995;322:481–7.

    Article  Google Scholar 

  8. Creager MA, Cooke JP, Mendelsohn ME, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990;86:228–34.

    Article  PubMed  CAS  Google Scholar 

  9. Meredith IT, Currie KE, Anderson TJ, et al. Postischemic vasodilation in human forearm is dependent on endothelium-derived nitric oxide. Am J Physiol. 1996;270:H1435-H40.

    PubMed  CAS  Google Scholar 

  10. Jarow J, Holmes A, Kloner RA. Viagra. New York, NY: M. Evans and Company; 1998;1–150.

    Google Scholar 

  11. Kloner RA, Mullin SH, Shook T, et al. Erectile dysfunction in the cardiac patient: How common and should we treat? J Urol. 2003;170:S46-S50.

    Article  PubMed  Google Scholar 

  12. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BN. Development and evaluation of an abridge 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res. 1999;11:319–26.

    Article  PubMed  CAS  Google Scholar 

  13. Kloner RA, Jarow JP. Erectile dysfunction and sildenafil citrate and cardiologists. Am J Card. 1999;83:576–82.

    Article  PubMed  CAS  Google Scholar 

  14. DeBusk R, Drory Y, Goldstein I, et al. Management of sexual dysfunction in patients with cardiovascular disease: Recommendations of the Princeton Consensus Panel. Am J Cardiol. 2000;86:175–81.

    Article  PubMed  CAS  Google Scholar 

  15. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med. 1998;338:1397–1404.

    Article  PubMed  CAS  Google Scholar 

  16. Conti CR, Pepine CJ, Sweeney M. Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease. Am J Cardiol. 1999; 83(Suppl):29C-34C.

    Article  PubMed  CAS  Google Scholar 

  17. Kloner RA, Brown M, Prisant LM, et al. Effect of sildenalfil in patients with erectile dysfunction taking antihypertensive therapy. Sildenafil Study Group. Am J Hypertension. 2001;14:70–3.

    Article  CAS  Google Scholar 

  18. Costabile RA. Optimizing treatment for diabetes mellitus induced erectile dysfunction. J Urol. 2003;170:S35-S9.

    Article  PubMed  Google Scholar 

  19. Kloner RA. Cardiovascular risk and sildenafil. Am J Cardiol. 2000;86:(Suppl):57F-61F.

    Article  PubMed  CAS  Google Scholar 

  20. Cheitlin MD, Hutter AM, Brindis RG, et al. ACC/AHA Expert Consensus Document. Use of sildenafil (Viagra) in patients with cardiovascular disease. J Am Coll Cardiol. 1999;33:273–82.

    Article  PubMed  CAS  Google Scholar 

  21. Zusman RM, Morales A, Glasser DB, Osterloh IH. Overall cardiovascular profile of sildenafil citrate. Am J Cardiol. 1999;83:35C-44C.

    Article  PubMed  CAS  Google Scholar 

  22. Webb DJ, Freestone S, Allen MJ, Muirhead GJ. Sildenafil citrate and blood pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist. Am J Cardiol. 1999;83:21C-8C.

    Article  PubMed  CAS  Google Scholar 

  23. Padma-Nathan H, Eardley I, Kloner RA, Laties AM, Montorsi F. A 4-year update on the safety of sildenafil citrate (Viagra). Urology. 2002;60:(Suppl 2B):67–90.

    Article  PubMed  Google Scholar 

  24. Shakir SA, Wilton LV, Boshier A, Layton D, Heeley E. Cardiovascular events in users of sildenafil: Results from first phase of prescription event monitoring in England. BMJ. 2001;322:651–2.

    Article  PubMed  CAS  Google Scholar 

  25. Emmick JT, Stuewe SR, Mitchell M. Overview of the cardiovascular effects of tadalafil. Europ Heart J. 2002;4(Suppl H):H32-H47.

    Article  CAS  Google Scholar 

  26. Thadani U, Smith W, Nash S, et al. The effect of vardenafil, a potent and highly selective phosphodiesterase-5-inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease. J Am Coll Cardiol. 2002;40:2006–12.

    Article  PubMed  CAS  Google Scholar 

  27. Arruda-Olson AM, Mahoney DW, Nehra A, Leckel M, Pellikka PA. Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease. A randomized crossover trial. JAMA. 2002;287:719–25.

    Article  PubMed  CAS  Google Scholar 

  28. Fox, KM, Thadani U, Ma PT, Nash SD. Time to onset of limiting angina during treadmill exercise in men with erectile dysfunction and stable chronic angina: Effect of sildenafil citrate [Abstract]. Circulation. 2001;107:II601.

    Google Scholar 

  29. Patterson D, MacDonald TM, Effron MB, et al. Tadalafil does not affect time to ischemia during exercise stress testing in patients with coronary artery disease. Circulation. 2002;106:(Suppl II):II-330.

    Google Scholar 

  30. Hermann HC, Chang G, Klugherz BD et al. Hemodynamic effects of sildenafil in men with severe coronary artery disease. N Engl J Med. 2000;342:1622–6.

    Article  Google Scholar 

  31. McCullough AR, Barada JH, Fawzy A, Guay AT, Hatzichristou D. Achieving treatment optimization with sildenafil citrate (Viagra®) in patients with erectile dysfunction. Urology. 2002;60:(Suppl 2B):28–38.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Cardiovascular Medicine Keck School of Medicine, University of Southern California, Los Angeles, Calif

    Robert A. Kloner MD, PhD (Professor of Medicine)

  2. Heart Institute, Good Samaritan Hospital, 1225 Wilshire Boulevard, 90017, Los Angeles, CA

    Robert A. Kloner MD, PhD (Professor of Medicine)

Authors
  1. Robert A. Kloner MD, PhD
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Additional information

The author is on the Speakers Bureau, a consultant and researcher for Pfizer, Lilly ICOS, and Bayer-GSK. The author does not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

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Kloner, R.A. Erectile dysfunction in the cardiac patient. Compr Ther 30, 50–54 (2004). https://doi.org/10.1007/s12019-004-0024-0

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  • DOI: https://doi.org/10.1007/s12019-004-0024-0

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