Abstract
Quercetin is a polyphenolic bioactive compound highly enriched in dietary fruits, vegetables, nuts, and berries. Quercetin and its derivatives like rutin and hyperoside are known for their beneficial effects in various neurological conditions including epilepsy. The clinical studies of quercetin and its derivatives in relation to epilepsy are limited. This review provides the evidence of most recent knowledge of anticonvulsant properties of quercetin and its derivatives on preclinical studies. Additionally, the studies demonstrating antiseizure potential of various plants extracts enriched with quercetin and its derivatives has been included in this review. Herein, we have also discussed neuroprotective effect of these bioactive compound and presented underlying mechanisms responsible for anticonvulsant properties in brief. Finally, limitations of quercetin and its derivatives as antiseizure compounds as well as possible strategies to enhance efficacy have also been discussed.
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The authors acknowledge the financial support provided by the Indian Council of Medical Research, New Delhi, India, to CP, University Grant Commission, New Delhi, India to JT, and Department of Biotechnology, New Delhi, India, to SSR.
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Indian Council of Medical Research, 3/1/3/123 Neuro/201 9-NCD-I, Chandra Prakash, UGC-DAE Consortium for Scientific Research, University Grant Commission, JNU/49/2018, Jyoti Tyagi, Department of Biotechnology, Ministry of Science and Technology, DBT/JRF/BET-18/1/2018/AL/181, Shyam Sunder Rabidas
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Prakash, C., Tyagi, J., Rabidas, S.S. et al. Therapeutic Potential of Quercetin and its Derivatives in Epilepsy: Evidence from Preclinical Studies. Neuromol Med 25, 163–178 (2023). https://doi.org/10.1007/s12017-022-08724-z
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DOI: https://doi.org/10.1007/s12017-022-08724-z