Abstract
High-intensity interval training (HIIT) and strength exercise are known to improve health markers, such as cardiovascular health, metabolic health, and cognitive function, as well as to reduce all-cause mortality. High-Intensity Functional Training (HIFT) is a training paradigm derived from both HIIT and strength exercise to elicit greater muscle recruitment than repetitive aerobic exercises, thereby improving both cardiovascular fitness and strength parameters. Herein, we provide a focused review of the known molecular mechanisms that underlie the beneficial effects of HIFT on cardiovascular, metabolic, and cognitive functions.
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References
Barak, B., Feldman, N., & Okun, E. (2015). Cardiovascular fitness and cognitive spatial learning in rodents and in humans. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 70(9), 1059–1066. https://doi.org/10.1093/gerona/glu162.
Ben-Zeev, T., Hirsh, T., Weiss, I., Gornstein, M., & Okun, E. (2020). The effects of high-intensity functional training (HIFT) on spatial learning, visual pattern separation and attention span in adolescents. Frontiers in Behavioral Neuroscience, 14(165), 577390. https://doi.org/10.3389/fnbeh.2020.577390.
Calverley, T. A., Ogoh, S., Marley, C. J., Steggall, M., Marchi, N., Brassard, P., et al. (2020). HIITing the brain with exercise: Mechanisms, consequences and practical recommendations. Journal of Physiology, 598(13), 2513–2530. https://doi.org/10.1113/JP275021.
Feito, Y., Heinrich, K. M., Butcher, S. J., & Poston, W. S. C. (2018). High-intensity functional training (HIFT): Definition and research implications for improved fitness. Sports (Basel). https://doi.org/10.3390/sports6030076.
Finkbeiner, S., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E. (1997). CREB: A major mediator of neuronal neurotrophin responses. Neuron, 19(5), 1031–1047. https://doi.org/10.1016/s0896-6273(00)80395-5.
Gehlert, S., Suhr, F., Gutsche, K., Willkomm, L., Kern, J., Jacko, D., et al. (2015). High force development augments skeletal muscle signalling in resistance exercise modes equalized for time under tension. Pflugers Archiv. European Journal of Physiology, 467(6), 1343–1356. https://doi.org/10.1007/s00424-014-1579-y.
Hansen, C. G., Ng, Y. L., Lam, W. L., Plouffe, S. W., & Guan, K. L. (2015). The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Research, 25(12), 1299–1313. https://doi.org/10.1038/cr.2015.140.
Impey, S., McCorkle, S. R., Cha-Molstad, H., Dwyer, J. M., Yochum, G. S., Boss, J. M., et al. (2004). Defining the CREB regulon: A genome-wide analysis of transcription factor regulatory regions. Cell, 119(7), 1041–1054. https://doi.org/10.1016/j.cell.2004.10.032.
Klossner, S., Durieux, A. C., Freyssenet, D., & Flueck, M. (2009). Mechano-transduction to muscle protein synthesis is modulated by FAK. European Journal of Applied Physiology, 106(3), 389–398. https://doi.org/10.1007/s00421-009-1032-7.
Lee, M. C., Okamoto, M., Liu, Y. F., Inoue, K., Matsui, T., Nogami, H., et al. (2012). Voluntary resistance running with short distance enhances spatial memory related to hippocampal BDNF signaling. Journal of Applied Physiology (1985), 113(8), 1260–1266. https://doi.org/10.1152/japplphysiol.00869.2012.
McLeod, M., Breen, L., Hamilton, D. L., & Philp, A. (2016). Live strong and prosper: The importance of skeletal muscle strength for healthy ageing. Biogerontology, 17(3), 497–510. https://doi.org/10.1007/s10522-015-9631-7.
Morland, C., Andersson, K. A., Haugen, Ø., Hadzic, A., Kleppa, L., Gille, A., et al. (2017). Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communication, 8, 15557. https://doi.org/10.1038/ncomms15557.
Pedersen, B. K., & Febbraio, M. A. (2012). Muscles, exercise and obesity: Skeletal muscle as a secretory organ. Nature Reviews Endocrinology, 8(8), 457–465. https://doi.org/10.1038/nrendo.2012.49.
Stary, C. M., & Hogan, M. C. (2016). Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers. Journal of Applied Physiology (1985), 120(10), 1260–1266. https://doi.org/10.1152/japplphysiol.01060.2015.
Tari, A. R., Norevik, C. S., Scrimgeour, N. R., Kobro-Flatmoen, A., Storm-Mathisen, J., Bergersen, L. H., et al. (2019). Are the neuroprotective effects of exercise training systemically mediated? Progress in Cardiovascular Diseases, 62(2), 94–101. https://doi.org/10.1016/j.pcad.2019.02.003.
Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2003). Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity. Neuroscience, 122(3), 647–657. https://doi.org/10.1016/j.neuroscience.2003.08.001.
Wackerhage, H., Schoenfeld, B. J., Hamilton, D. L., Lehti, M., & Hulmi, J. J. (2019). Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise. Journal of Applied Physiology (1985), 126(1), 30–43. https://doi.org/10.1152/japplphysiol.00685.2018.
Wilke, J. (2020). Functional high-intensity exercise is more effective in acutely increasing working memory than aerobic walking: An exploratory randomized, controlled trial. Scientific Reports, 10(1), 12335. https://doi.org/10.1038/s41598-020-69139-z.
Wu, J., Weisshaar, N., Hotz-Wagenblatt, A., Madi, A., Ma, S., Mieg, A., et al. (2020). Skeletal muscle antagonizes antiviral CD8. Science Advances, 6(24), eaba3458. https://doi.org/10.1126/sciadv.aba3458.
Acknowledgements
This work was funded by the Paul Feder fund for Alzheimer’s disease research. We would like to thank Yael Laure for editing this manuscript.
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This work was funded by the Paul Feder fund for Alzheimer’s disease research.
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Ben-Zeev, T., Okun, E. High-Intensity Functional Training: Molecular Mechanisms and Benefits. Neuromol Med 23, 335–338 (2021). https://doi.org/10.1007/s12017-020-08638-8
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DOI: https://doi.org/10.1007/s12017-020-08638-8