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NeuroMolecular Medicine

, Volume 18, Issue 3, pp 465–473 | Cite as

Preserving Brain Function in Aging: The Anti-glycative Potential of Berry Fruit

  • Nopporn Thangthaeng
  • Shibu M. Poulose
  • Marshall G. Miller
  • Barbara Shukitt-Hale
Review Paper

Abstract

Advanced glycation end products (AGEs) are naturally occurring macromolecules that are formed in vivo by the non-enzymatic modification of proteins, lipids, or nucleic acids by sugar, even in the absence of hyperglycemia. In the diet, AGEs are found in animal products, and additional AGEs are produced when those foods are cooked at high temperatures. Studies have linked AGEs to various age-related physiological changes, including wrinkles, diabetic complications, and neurodegenerative disease, including Alzheimer’s disease. Dietary berry fruits have been shown to reduce the severity or slow the progression of many physiological changes and disease pathologies that accompany aging. Emerging evidence has shown that the phytochemicals found in berry fruits exhibit anti-glycative activity. In this review, we briefly summarize the current evidence supporting the neuroprotective anti-glycative activity of berry fruits and their potential to preserve cognitive function during aging.

Keywords

Advanced glycation end products AGEs Aging Berry Cognition Glycation 

Abbreviations

AGE

Advanced glycation end product

dAGE

Dietary AGE

AD

Alzheimer’s disease

ROS

Reactive oxygen species

CML

Carboxymethyl-lysine

MG

Methylglyoxal

TCA cycle

Tricarboxylic acid cycle

T2DM

Type 2 diabetes mellitus

sMG

Serum methylglyoxal

RAGE

Receptor for AGE

BSC I

Bovine skin collagen type I

BSA

Bovine serum albumin

HSA

Human serum albumin

LTP

Long-term potentiation

STZ

Streptozotocin

Notes

Compliance with Ethical Standards

Conflicts of interest

The authors declare no financial or other conflicts of interest in the writing of this paper.

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Copyright information

© Springer Science+Business Media New York (outside the USA) 2016

Authors and Affiliations

  • Nopporn Thangthaeng
    • 1
  • Shibu M. Poulose
    • 1
  • Marshall G. Miller
    • 1
  • Barbara Shukitt-Hale
    • 1
  1. 1.USDA-ARSHuman Nutrition Research Center on Aging at Tufts UniversityBostonUSA

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