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HIF-1α Genetic Variants and Protein Expression Confer the Susceptibility and Prognosis of Gliomas

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Abstract

To investigate the role of HIF-1α genetic polymorphism of c.1772C>T and c.1790G>A in the incidence and prognosis of gliomas in a Chinese cohort, a total of 387 gliomas patients and 437 age- and sex-matched healthy controls were recruited. The genetic polymorphism of c.1772C>T and c.1790G>A was determined. We found that the genotype distribution at c.1772C>T showed significant difference between patients and controls. Multivariable analyses showed a significantly higher risk for gliomas in 1772TT genotype carriers (odds ratio 2.68, with CC as reference). In addition, we also found a significantly higher risk for grade III + IV gliomas was observed in 1772TT genotype carriers (odds ratio 2.21, with CC as reference). The overall survival rates in patients with 1772TT or 1772CT genotype were markedly lower compared with patients with CC (both P < 0.01). Our in vitro studies revealed that HIF-1α regulates the proliferation, migration and invasion of human glioma U251 cells. This study suggests that the c.1772C>T polymorphisms may be used as a molecular marker for gliomas occurrence, grades and clinical outcome in gliomas patients.

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Acknowledgments

This study was supported by grants from the National Nature Science Foundations of China(NSFC, No. 81270039 and No. 81272785).

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Authors and Affiliations

  1. Department of Neurosurgery, Daping Hospital, Third Military Medical University, Chongqing, China

    Liang Yi, Ji Zhou, Lunshan Xu, Qing Ouyang, Hong Liang & Minhui Xu

  2. Department of Cardiology, Hangzhou Hospital of Nanjing Medical University, Hangzhou, China

    Xuwei Hou

  3. Department of Neurosurgery, Fuzhou General Hospital of Xiamen University, Fuzhou, Fujian, China

    Zhaocong Zheng & Hongjie Chen

Authors
  1. Liang Yi
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  2. Xuwei Hou
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  3. Ji Zhou
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  4. Lunshan Xu
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  5. Qing Ouyang
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  6. Hong Liang
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  7. Zhaocong Zheng
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  8. Hongjie Chen
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  9. Minhui Xu
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Corresponding authors

Correspondence to Hongjie Chen or Minhui Xu.

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Liang Yi and Xuwei Hou have contributed equally to this work.

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Yi, L., Hou, X., Zhou, J. et al. HIF-1α Genetic Variants and Protein Expression Confer the Susceptibility and Prognosis of Gliomas. Neuromol Med 16, 578–586 (2014). https://doi.org/10.1007/s12017-014-8310-1

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  • DOI: https://doi.org/10.1007/s12017-014-8310-1

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