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PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population

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PICALM gene rs3851179 polymorphism was reported to an Alzheimer’s disease (AD) susceptibility locus in a Caucasian population. However, recent studies reported consistent and inconsistent results in an Asian population. Four studies indicated no association between rs3851179 and AD in a Chinese population and one study reported weak association in a Japanese population. We consider that the failure to replicate the significant association between rs3851179 and AD may be caused by at least two reasons. The first reason may be the genetic heterogeneity in AD among different populations, and the second may be the relatively small sample size compared with large-scale GWAS in Caucasian ancestry. In order to confirm this view, in this research, we first evaluated the genetic heterogeneity of rs3851179 polymorphism in Caucasian and Asian populations. We then investigated rs3851179 polymorphism in an Asian population by a pooled analysis method and a meta-analysis method. We did not observe significant genetic heterogeneity of rs3851179 in the Caucasian and Asian populations. Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods. We believe that our findings will be very useful for future genetic studies in AD.

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This research is supported by grants from the National Nature Science Foundation of China (Grant number 31171219, 81271213, and 31200934) and US-China Biomedical Collaborative Research Program (NSFC Grant number 81261120404) to Keshen Li, and One Hundred Person Project of the Chinese Academy of Sciences (KSCX2-YW-BR-3)

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The authors reported no biomedical financial interests or potential conflicts of interest.

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Correspondence to Bin Zhao or Keshen Li.

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Guiyou Liu and Shuyan Zhang contributed equally to this work.

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Liu, G., Zhang, S., Cai, Z. et al. PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population. Neuromol Med 15, 384–388 (2013).

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