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Traumatic Brain Injury Elicits Similar Alterations in α7 Nicotinic Receptor Density in Two Different Experimental Models

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Abstract

Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. Previous studies have shown alterations in the central cholinergic neurotransmission after TBI. We therefore determined α7 nicotinic acetylcholine receptor (nAChR) densities in newborn piglets and adult rats after experimental TBI. Thirteen newborn piglets (post-TBI survival time: 6 h) underwent fluid percussion (FP) injury (n = 7) or sham operation (n = 6). Furthermore, adult rats randomized into three groups of post-TBI survival times (2, 24, 72 h) received controlled cortical impact injury (CCI, n = 8) or sham operation (n = 8). Brains were frozen, sagittally cut and incubated with the α7-specific radioligand [125I]α-bungarotoxin for autoradiography. In injured newborn piglets, decreased α7 receptor densities were observed in the hippocampus (−38%), the hippocampus CA1 (−40%), thalamus (−30%) and colliculus superior (−30%). In adult rats, CCI decreased the receptor densities (between −16 and −47%) in almost any brain region within 2 and 24 h. In conclusion, widespread and significantly lowered α7 nAChR densities were demonstrated in both TBI models. Our results suggest that a nearly similar TBI-induced decrease in the α7 density in the brain of immature and adult animals is found, even with the differences in species, age and experimental procedures. The alterations make the α7 nAChR a suitable target for drug development and neuroimaging after TBI.

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Abbreviations

ACh:

Acetylcholine

AChE:

Acetylcholine esterase

AChR:

Acetylcholine receptor(s)

CCI:

Controlled cortical impact

ChAT:

Choline acetyltransferase

FP:

Fluid percussion

mAChR:

Muscarinic acetylcholine receptor(s)

nAChR:

Nicotinic acetylcholine receptor(s)

PET:

Positron emission tomography

PSL:

Photostimulated luminescence

TBI:

Traumatic brain injury

vAChT:

Vesicular acetylcholine transporter

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Authors and Affiliations

  1. Institute of Radiopharmacy, Research Site Leipzig, Research Center Dresden-Rossendorf, Permoserstraße 15, 04318, Leipzig, Germany

    Peter-Georg Hoffmeister, Cornelius K. Donat & Peter Brust

  2. Department of Neurosurgery, University of Leipzig, Leipzig, Germany

    Martin U. Schuhmann, Cornelia Voigt & Jürgen Meixensberger

  3. Department of Neurosurgery, Zentralklinik Bad Berka, Bad Berka, Germany

    Bernd Walter

  4. Institute of Molecular Cell Biology, Friedrich-Schiller-University, Jena, Germany

    Bernd Walter & Reinhard Bauer

  5. Institute of Pharmacy, University of Leipzig, Leipzig, Germany

    Karen Nieber

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  1. Peter-Georg Hoffmeister
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  2. Cornelius K. Donat
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Correspondence to Cornelius K. Donat.

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Peter-Georg Hoffmeister and Cornelius K. Donat contributed equally to this study.

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Hoffmeister, PG., Donat, C.K., Schuhmann, M.U. et al. Traumatic Brain Injury Elicits Similar Alterations in α7 Nicotinic Receptor Density in Two Different Experimental Models. Neuromol Med 13, 44–53 (2011). https://doi.org/10.1007/s12017-010-8136-4

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