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A Comprehensive Review of Sensitization and Allergy to Soy-Based Products

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Abstract

Since 1943, cases of sensitization or allergy to soy-based formulas (SBFs) have been described without any consensus on their real prevalence. We identified the adjusted prevalence of IgE-mediated soy allergies in children and performed a secondary analysis of the impact of age (less than and more than 6 months). We performed a systematic review with meta-analysis of studies published from 1909 to 2013 in PubMed, Embase, LILACS, ARTEMISA, Cochrane, Bandolier, DARE and the GRADE system for grading quality. Results are presented in tables and graphs using a forest plot. The 40 studies identified established weighted prevalence of soy allergies of 0 to 0.5 % (0.27) for the general population, 0.4 to 3.1 % (1.9) for the referred population, and 0 to 12.9 % (2.7) for allergic children. Prevalence of sensitization after the use of SBFs is 8.7 and 8.8 %, depending on the method used. The prevalence of allergies to soy and IgE sensitization to the use of SBFs is less than reported. Not enough evidence exists to show a higher risk of allergy in infants younger than 6 months. The concern about soy allergy is no reason to postpone the use of SBFs in IgE-mediated cow's milk allergy infants until the age of 6 months.

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Authors and Affiliations

  1. Allergy and Immunology Institute, Assaf Harofeh Medical Center, Zerifin, Israel

    Yitzhak Katz

  2. Department of Pediatrics, Tel Aviv University Sackler School of Medicine, Tel Aviv, Israel

    Yitzhak Katz

  3. National Institute of Perinatology, Hospital General, Mexico City, Mexico

    Pedro Gutierrez-Castrellon

  4. Facultad de Medicina, Universidad LaSalle, Mexico City, Mexico

    Manuel Gea González

  5. Instituto Mexicano del Seguro Social, Mexico City, Mexico

    Rodolfo Rivas

  6. Children’s Hospital of Mexico, Mexico City, Mexico

    Rodolfo Rivas

  7. National University of Singapore, Singapore, Singapore

    Bee Wah Lee

  8. National Institute of Child Health, Lima, Peru

    Pedro Alarcon

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  1. Yitzhak Katz
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Katz, Y., Gutierrez-Castrellon, P., González, M.G. et al. A Comprehensive Review of Sensitization and Allergy to Soy-Based Products. Clinic Rev Allerg Immunol 46, 272–281 (2014). https://doi.org/10.1007/s12016-013-8404-9

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