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The Future of Autoimmunity

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Abstract

There have been enormous strides in our understanding of autoimmunity. These strides have come under the umbrellas of epidemiology, immunological phenotype and function, disease definitions and classification and especially new therapeutic reagents. However, while these advances have been herculean, there remains enormous voids. Some of these voids include genetic susceptibility and the interaction of genes and environment. The voids include induction of tolerance in preclinical disease and definitions of host susceptibility and responses to the expensive biologic agents. The voids include the so-called clustering of human autoimmune diseases and the issues of whether the incidence is rising in our western society. Other voids include the relationships between microbiology, vaccination, gut flora, overzealous use of antibiotics, and the role of nanoparticles and environmental pollution in either the induction or the natural history of disease. One cannot even begin to address even a fraction of these issues. However, in this special issue, we are attempting to discuss clinical issues in autoimmunity that are not usually found in generic reviews. The goal is to bring to the readership provocative articles that ultimately will lead to improvement in patient care.

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References

  1. Shepshelovitch D, Shoenfeld Y (2005) Prediction and prevention of autoimmune diseases—additional aspects of the mosaic of autoimmunity. Lupus 15:183–190

    Article  Google Scholar 

  2. Shoenfeld Y, Carp HJA, Molina V, Blank M, Cervera R, Balasch J, Tincani A, Faden D, Lojacono A, Doria A, Konova E, Meroni PL (2006) Autoantibodies and prediction of reproductive failure. Amer J of Reproduct Immunol 56:337–344

    Article  CAS  Google Scholar 

  3. Shoenfeld Y, Blank M, Abu-Shakra M, Amital H, Barzilai O, Berkun Y, Bizzaro N, Gilburd B, Zandman-Goddard G, Katz U, Krause I, Langevitz P, Mackay IR, Orbach H, Ram M, Sherer Y, Toubi E, Gershwin ME (2008) The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases—2008. IMAJ 10:13–19

    PubMed  Google Scholar 

  4. Agmon-Levin N, Shoenfeld Y (2008) Prediction and prevention of autoimmune skin disorders. Arch Dermatol Res 301:57–64

    Google Scholar 

  5. Arnson Y, Amital H, Shoenfeld Y (2007) Vitamin D and autoimmunity: new etiological and therapeutical considerations. Ann Rheum Dis 66:1137–1142

    Article  PubMed  CAS  Google Scholar 

  6. Carvalho ZF, Blank M, Kiss E, Tarr T, Amital H, Shoenfeld Y (2007) Anti-vitamin D, vitamin D in SLE preliminary results. Ann NY Acad Sci 1109:550–557

    Article  PubMed  CAS  Google Scholar 

  7. Orbach H, Zandman-Goddard G, Amital H, Barak B, Szekaanecz Z, Szucs G, Danko K, Nagy E, Csepany T, Carvalho JF, Doria A, Shoenfeld Y (2007) Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin D and TPA levels in autoimmune diseases. Ann NY Acad Sci 1109:385–400

    Article  PubMed  CAS  Google Scholar 

  8. Shoenfeld N, Amital H, Shoenfeld Y (2009) The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. Nature Rheumatol 5:99–105

    Article  CAS  Google Scholar 

  9. Shapira Y, Agmon-Levin N, Shoenfeld Y (2010) Mycobacterium tuberculosis, autoimmunity, and vitamin D. Clin Rev Allerg Immunol 38:169–177

    Article  CAS  Google Scholar 

  10. Amital H, Szekanecz Z, Szücs G, Dankó K, Nagy E, Csépány T, Kiss E, Doria A, Corocher N, Agmon-Levin N, Orbach H, Barak V, Zandman-Goddard G, Shoenfeld Y (2010) Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D? Ann Rheum Dis 69:1155–1157

    Article  PubMed  CAS  Google Scholar 

  11. Toubi E, Shoenfeld Y (2010) The role of vitamin D in regulating immune responses. Isr Med Assoc J 12:174–5

    PubMed  Google Scholar 

  12. Souberbielle J-C, Body J-J, Laappe JM, Plebani M, Shoenfeld Y, Wang TJ, Bischoff-Ferrari A, Cavalier E, Ebeling PR, Fardellone P, Gandini S, Gruson D, Guerin AP, Heickendorff L, Hollis BW, Ish-Shalom S, Gullaume J, von Landenberg P, Largura A, Olsson T, Pierrot-Deseilligny C, Pilz S, Tincani A, Valcour A, Zittermann A (2010) Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations for clinical practice. Autoimmun Rev 9:709–715

    Article  PubMed  CAS  Google Scholar 

  13. Agmon-Levin N, Blank M, Zandman-Goddard G, Orbach H, Meroni PL, Tincani A, Doria A, Cervera R, Miesbach W, Stojanovich L, Barak V, Porat-Katz BS, Amital H, Shoenfeld Y (2011) Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis 20:145–150

    Article  CAS  Google Scholar 

  14. Oren Y, Shapira Y, Agmon-levin N, Kivity S, Zafrir Y, Altman A, Lerner A, Shoenfeld Y (2010) Vitamin D insufficiency in a sunny environment: a demographic and seasonal analysis. IMAJ 12:751–756

    PubMed  Google Scholar 

  15. Arnson Y, Amital H, Agmon-Levin N, Alon D, Sanchez-Castanon M, Lopez-Hoyos M, Matucci-Cerinic M, Szuces G, Shapira Y, Szekanecz Z, Shoenfeld Y (2011) Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: a retrospective cohort study and review of the literature. Autoimmun Rev 10:490–494

    Article  PubMed  CAS  Google Scholar 

  16. Kivity S, Agmon-Levin N, Zisappl M, Shapira Y, Nagy EV, Danko K, Szekanecz Z, Langevitz P, Shoenfeld Y (2011) Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol 8:243–7

    Article  PubMed  CAS  Google Scholar 

  17. Lerner A, Shapira Y, Agmon-Levin N, Pacht A, Ben-Ami Shor D, Lopez HM, Sanchez-Castanon M, Shoenfeld Y (2011) The clinical significance of 25OH-vitamin D status in Celiac disease. Clin Rev Allergy Immunol. doi:10.1007/s12016-010-8237-8.

  18. Hajas A, Sandor J, Casathy L, Csipo I, Barath S, Paragh G, Seres I, Szegedi G, Shoenfeld Y, Bodolay E (2011) Vitamin D insufficiency in a large MCTD population. Autoimmun Rev 10:317–24

    Article  PubMed  CAS  Google Scholar 

  19. Shoenfeld Y, Gilburd B, Abu-Shakra M, Amital H, Barzilai O, Berkun Y, Blank M, Zandman-Goddard G, Katz U, Krause I, Langevitz P, Levy Y, Orbach H, Pordeus V, Ram M, Sherer Y, Toubi E, Tomer Y (2008) The mosaic of autoimmunity: genetic factors involved in autoimmune diseases—2008. IMAJ 10:3–7

    PubMed  Google Scholar 

  20. Shoenfeld Y, Zandman-Goddard G, Stojanovich L, Cutolo M, Amital H, Levy Y, Abu-Shakra M, Barzilai O, Berkun Y, Blank M, de Carvalho JF, Doria A, Gilburd B, Katz U, Krause I, Langevitz P, Orbach H, Pordeus V, Ram M, Toubi E, Sherer Y (2008) The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases—2008. IMAJ 10:8–12

    PubMed  Google Scholar 

  21. Barzilai O, Sherer Y, Ram M, Izhaky D, Anaya JM, Shoenfeld Y (2007) Epstein–Barr virus and cytomegalovirus in autoimmune diseases are they truly notorious? a preliminary report. Ann NY Acad Sci 1108:567–577

    Article  PubMed  CAS  Google Scholar 

  22. Zandman-Goddard G, Berkun Y, Barzilai O, Boaz M, Blank M, Ram M, Sherer Y, Anaya JM, Shoenfeld Y (2009) Exposure to Epstein–Barr virus infection is associated with mild systemic lupus erythematosus disease. Ann NY Acad Sci 1173:658–663

    Article  PubMed  CAS  Google Scholar 

  23. Pender MP (2009) Preventing and curing multiple sclerosis by controlling Epstein–Barr virus infection. Autoimmun Rev 8:563–8

    Article  PubMed  CAS  Google Scholar 

  24. Youinou P, Pers JO, Gershwin ME, Shoenfeld Y (2010) Geo-epidemiology and autoimmunity. J Autoimmunity 34:J163–J167, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  CAS  Google Scholar 

  25. Shapira Y, Agmon-Levin N, Shoenfeld Y (2010) Defining and analyzing geoipedemiology and human autoimmunity. J Autoimmun 34:J168–J177, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  26. Hoffmann MH, Trembleau S, Muller S, Steiner G (2010) Nucleic acid-autoantigens: pathogenic involvement and therapeutic potential. J Autoimmun 34:J178–J206, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  27. Brooks WH, Dantec CL, Pers JO (2010) Epigenetics and autoimmunity. J Autoimmun 34:J207–J219, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  28. JL Rou d, OwConnell RM, Mazmanian SK (2010) Coordination of tolerogenic immune responses by the commensal microbiota. J Autoimmun 34:J220–J225, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  CAS  Google Scholar 

  29. Powel JJ, Faeia N, Thomas-Mckay E, Pele LC (2010) Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun 34:J226–J233, Published in book: Shoenfeld Y, Youinou P, Gershwin EM. (Guest Editors). The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  CAS  Google Scholar 

  30. Chang C (2010) The immune effects of naturally occurring and synthetic nanoparticles. J Autoimmun 34:J224–J246, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Google Scholar 

  31. Maverakis E, Miyamura Y, Bowen MP, Correa G, Ono Y, Goodarzi H (2010) Light, including ultraviolet. J Autoimmun 34:J247–J257, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  32. Arnson Y, Shoenfeld Y, Amital H (2010) Effects of tobacco on immunity, inflammation and autoimmunity. J Autoimmun 34:J258–J265, Published in Book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  33. Chang C, Gershwin ME (2010) Drugs and autoimmunity—a contemporary review and mechanistic approach. J Autoimmun 34:J266–J275, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  34. Chen M, Daha MR, Kallenberg CGM (2010) The complement system in systemic autoimmune disease. J Autoimmun 34:276–J286, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  CAS  Google Scholar 

  35. Borchers AT, Maguwa SM, Keen CL, Gershwin ME (2010) The implications of autoimmunity and pregnancy. J Autoimmun 34:J287–J299, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  36. Invernizzi P (2010) Geoepidemiology of autoimmune liver diseases. J Autoimmun 34:J300–J306, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  37. Hemminki K, Li X, Sundquist J, Sundquist K (2010) The epidemiology of Graves' disease: evidence of a genetic and an environmental contribution. J Autoimmun 34:J307–J313, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  38. Chandran V, Raycheudhuri SP (2010) Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J Autoimmun 34:J314–J321, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  39. Tomer Y (2010) Hepatitis C and interferon induced thyroiditis. J Autoimmun 34:J322–J326, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  40. Zeki AA, Schivo M, Chan AL, Hardin KA, Kenyon NJ, Albertson TE, Rosenquist GL, Louie S (2010) Geoepidemiology of COPD and idiopathic pulmonary fibrosis. J Autoimmun 34:J327–J338, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  41. Selmi C (2010) The worldwide gradient of autoimmune conditions. Autoimmun Rev 9:A247–A250, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  42. Mackay IR (2010) Travels and travails of autoimmunity: A historical journey from discovery to rediscovery. Autoimmun Rev 9:A251–A258, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  43. Lleo A, Invernizzi P, Gao B, Podda M, Gershwin ME (2010) Definition of human autoimmunity—autoantibodies versus autoimmune disease. Autoimmun Rev 9:A259–A266, Published in book: Shoenfeld Y, Youinou P, Gershwin EM. (Guest Editors). The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  44. Selmi C, Tsuneyama K (2010) Nutrition geoepidemiology, and autoimmunity. Autoimmun Rev 9:A267–A270, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors). The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  45. Stojanovich L (2010) Stress and autoimmunity. Autoimmun Rev 9:A271–A276, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  46. Tobon GJ, Youinou P, Saraux A (2010) The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis. Autoimmun Rev 9:A288–A292, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors). The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  47. Chen M, Kallenberg CGM (2010) The environment, geoepidemiology and ANCA-associated vasculitides. Autoimmun Rev 9:A293–A298, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  48. Biggioggero M, Meroni PL (2010) The geoepidemiology of the antiphospholipid antibody syndrome. Autoimmun Rev 9:A299–A304, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  49. Mavragani CP, Moutsopoulos HM (2010) The geoepidemiology of Sjogren's syndrome. Autoimmun Rev 9:A305–A310, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  50. Ranque B, Mouthon L (2010) Geoepidemiology of systemic sclerosis. Autoimmun Rev 9:A311–A318, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  51. Berkun Y, Padeh S (2010) Environmental factors and the geoepidemiology of juvenile idiopathic arthritis. Autoimmun Rev 9:A319–A324, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  52. Ehrenfeld M (2010) Geoepidemiology: the environment and spondyloarthropathies. Autoimmun Rev 9:A325–A329, Published in book: Shoenfeld Y, Youinou P, Gershwin EM. (Guest Editors). The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  53. Prieto S, Grau JM (2010) The geoepidemiology of autoimmune muscle disease. Autoimmun Rev 9:A330–A334, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  54. Sands J, Tuscano JM (2010) Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders. Autoimmun Rev 9:A335–A341, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  55. Deane S, Teuber SS, Gershwin ME (2010) The geoepidemiology of immune thrombocytopenic purpura. Autoimmun Rev 9:A342–A349, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam,The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  56. Lambert JF, Nydegger UE (2010) Geoepidemiology of autoimmune hemolytic anemia. Autoimmun Rev 9:A350–A354, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  57. Borchers AT, Uibo R, Gershwin ME (2010) The epidemiology of type 1 diabetes. Autoimmun Rev 9:A355–A365, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors). The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  58. Segelmark M, Hellmark T (2010) Autoimmune kidney disease. Autoimmun Rev 9:A366–A371, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  59. Logan I, Bowlus CL (2010) The geoepidemiology of autoimmune intestinal disease. Autoimmun Rev 9:A372–A378, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  60. Meyer N, Misery L (2010) Geoepidemiologic consideration of auto-immune pemphigus. Autoimmun Rev 9:A379–A382, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  61. Meyer A, Levy Y (2010) Chapter 33: geoepidemiology of myasthenia gravis. Autoimmun Rev 9:A383–A386, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors) The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  62. Milo R, Kahana E (2010) Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev 9:A387–A394, Published in book: Shoenfeld Y, Youinou P, Gershwin EM (guest editors). The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  CAS  Google Scholar 

  63. Bhat A, Naguwa S, Cheema G, Gershwin ME (2010) The epidemiology of transverse myelitis. Autoimmun Rev 9:A395–A399, Published in book: Shoenfeld Y, Youinou P, Gershwin EM. (guest editors). The environment geoepidemiology and autoimmune diseases. Elsevier, Amsterdam, The Netherlands. Printed in the UK and The Netherlands

    Article  PubMed  Google Scholar 

  64. Borchers AT, Naguwa SM, Shoenfeld Y, Gershwin ME (2010) The geoepidemiology of systemic lupus erythematosus. Autoimmun Rev 9:A277–A287

    Article  PubMed  CAS  Google Scholar 

  65. Shapira Y, Agmon-Levin N, Shoenfeld Y (2010) Geoepidemiology of autoimmune rheumatic diseases. Nat Rev Rheumatol 6:468–476

    Article  PubMed  CAS  Google Scholar 

  66. To smell the immune system (2006) Olfaction, autoimmunity and brain involvement. Autoimmune Rev 6:54–60

    Article  CAS  Google Scholar 

  67. Katzav A, Solodeev I, Brodsky O, Chapman J, Pick CG, Blank M, Zhang W, Reichlin M, Shoenfeld Y (2007) Induction of autoimmune depression in mice by anti-ribosomal P antibodies via the limbic system. Arth Rheum 56:938–948

    Article  CAS  Google Scholar 

  68. Shoenfeld Y (2007) To smell autoimmunity: anti-P-Ribosomal autoantibodies, depression, and the olfactory system. J Autoimmunity 28:165–169

    Article  CAS  Google Scholar 

  69. Blank M, Beinglass I, Shoenfeld Y (2007) The therapeutic potential of targeting anti-ribosomal-P antibody in treating SLE patients with depression. Expert Opin Biol Ther 7:1283–1285

    Article  PubMed  CAS  Google Scholar 

  70. Katzav A, Ben-Ziv T, Chapman J, Blank M, Reichlin M, Shoenfeld Y (2008) Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS-SLE (depression). J Autoimmun 31:393–398

    Article  PubMed  CAS  Google Scholar 

  71. Shoenfeld N, Agmon-Levin N, Flitman-Katzevman I, Paran D, Porat Katz B, Kivity S, Langevitz P, Zandman-Goddard G, Shoenfeld Y (2009) The sense of smell in systemic lupus erythematosus. Arth Rheum 60(5):1484–1487

    Article  Google Scholar 

  72. Samuel-Datum M, Szyper-Kravitz M, Yehuda S (2009) Olfacto: Smell: integrating neurodegeneration and autoimmunity—a personal view. Acta Reumatol Port 34:190–196, Portuguese

    Google Scholar 

  73. Perricone C, Agmon-Levin N, Shoenfeld N, de Carolis C, Guarino MD, Gigliucci G, Milana I, Novelli L, Valesini G, Perricone R, Shoenfeld Y (2011) Evidence of impaired sense of smell in hereditary angioedema. Allergy 66:149–154

    Article  PubMed  CAS  Google Scholar 

  74. Agmon-Levin N, Shoenfeld Y (2008) Chronic fatigue syndrome with autoantibodies—the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant. Autoimmun Rev 8:52–55

    Article  Google Scholar 

  75. Israeli E, Agmon-Levin N, Blank M, Shoenfeld Y (2009) Adjuvants and autoimmunity. Lupus 18:1217–1225

    Article  PubMed  CAS  Google Scholar 

  76. Shoenfeld Y, Agmon-Levin N (2011) ‘ASIA’—autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun 36:4–8

    Article  PubMed  CAS  Google Scholar 

  77. Shoenfeld Y, Agmon-Levin N (2011) Abstract of: ‘ASIA’—autoimmune (auto-inflammatory) syndrome induced by adjuvant- a new syndrome to be defined. In: Abstracts of selected invited lectures. Lupus 20:340–347

    Article  Google Scholar 

  78. Shoenfeld Y (2011) Autoimmune (autoinflammatory) syndrome induced by adjuvants provides a diagnostic framework for enigmatic conditions. The Rheumatologist 6:26–32

    Google Scholar 

  79. Perricone C, Agmon-Levin N, Valesini G, Shoenfeld Y (2011) Vaccination in patients with chronic or autoimmune rheumatic diseases: the ego, the id and the superego. Joint Bone Spine. doi:10.1016/j.jbspin.2011.10.006.

  80. Rosenblum H, Shoenfeld Y, Amital H (2011) The common immunogenic etiology of chronic fatigue syndrome: from infections to vaccines via adjuvants to the ASIA syndrome. Infect Dis Clin North Am 25:851–63

    Article  PubMed  Google Scholar 

  81. Cervera R (2011) “ASIA”: q new systemic autoimmune syndrome? Lupus 20:665–666

    Article  PubMed  CAS  Google Scholar 

  82. Carvalho JF, Barros SM, Branco JC, Fonseca JE (2011) ASIA or shoenfeld’s syndrome: highlighting different perspectivas for diffuse chronic pain. Acta Rheumatol Port 36:10–12

    CAS  Google Scholar 

  83. Barros SM, Carvalho JF (2011) Shoenfeld’s syndrome after pandemic influenza A/H1N1 vaccination. Acta Rheumatol Port 36:65–68

    CAS  Google Scholar 

  84. Pereira JP, Barroso C, Evangelista T, Fonseca JE, Pereira da Silva JA (2011) Macrophagic myofasciitis: a case report of autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Acta Rheumatol Port 36:75–76

    Google Scholar 

  85. Israeli E, Pardo A (2011) The sick building syndrome as a part of the autoimmune (auto-inflammatory) syndrome induced by adjuvants. Mod Rheumatol 21:235–239

    Article  PubMed  Google Scholar 

  86. Meroni PL (2011) Autoimmune of auto-inflammatory syndrome induced by adjuvants (ASIA): old truths and a new syndrome? J AI 36:1–3

    CAS  Google Scholar 

  87. Batista-Duharte A, Lindblad EB, Oviedo-Orta E (2011) Progress in understanding adjuvant immunotoxicity mechanisms. Toxicol Lett 203:97–105

    Article  PubMed  CAS  Google Scholar 

  88. Bogdanos DP, Rigopoulou EL, Smyk DS, Roggenbuck D, Reinhold D, Forbes A, Laass M, Conrad K (2011) Dianostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn’s disease specific-pancreatic autoantibodies. Autoimmun Rev. doi:10.1016/j.autrev.2011.09.004.

  89. Lepse N, Abdulahad WH, Kallenberg CG, Heeringa P (2011) Immune regulatory in ANCA-associated vasculitides. Autoimmun Rev. doi:10.1016/j.autrev.2011.08.002.

  90. Murdaca G, Colombo BM, Puppo F (2011) Emerging biological drugs: a new therapeutic approach for systemic lupus erythematosus. An update upon efficacy and adverse events. Autoimmun Rev. doi:10.1016/j.autrev.2011.07.006.

  91. Chimenti MS, Graceffa D, Perricone R (2011) Anti-TNFa discontinuation in rheumatoid and psoriatic arthritis: is it possible after disease remission? Autoimmun Rev 10:636–40

    Article  PubMed  CAS  Google Scholar 

  92. Laccarino L, Ghirardello A, Canova M, Zen M, Bettio S, Nalotto L, Punnzi L, Doria A (2011) Anti-annexins autoantibodies: their role as biomarkers of autoimmune diseases. Autoimmun Rev 10:553–8

    Article  CAS  Google Scholar 

  93. Liao WW, Arthur JW (2011) Prediction peptide binding to major histocompatibility complex molecules. Autoimmun Rev 10:469–73

    Article  PubMed  CAS  Google Scholar 

  94. Ingegnoli F, Favalli EG, Meroni PL (2011) Does poymorphysm of genes coding for pro-inflammatory mediators predict the clinical response to TNF Alpha blocking agents? A review analysis of the literature. Autoimmun Rev 10:460–3

    Article  PubMed  CAS  Google Scholar 

  95. Engel P, Gomez-Puerta JA, Ramos-Casals M, Lozano F, Bosch Z (2011) Therapeutic targeting of B cells for rheumatic autoimmune diseases. Autoimmun Rev 63:127–56

    CAS  Google Scholar 

  96. Hemdan NY, Birkenmeier G, Wichmann G, Abu El-Saad AM, Krieger T, Conrad K, Sack U (2010) Inteleukin-17 producing T helper cells in autoimmunity. Autoimmun Rev 9:785–92

    Article  PubMed  CAS  Google Scholar 

  97. Caporali R, Sarzi-Puttini P, Atzeni F, Gorla R, Filippini M, Marchesoni A, Favalli EG, Bobio-Pallavici F, Montecucco C (2010) Switching TNF-alpha antagonists in rheumatoid arthritis: the experience of the LORHEN registry. Autoimmun Rev 9:465–9

    Article  PubMed  CAS  Google Scholar 

  98. Leung PS, Shu SA, Kenny TP, Wu PY, Tao MH (2010) Development and validation of gene therapies in autoimmune diseases: epidemiology to animal models. Autoimmun Rev 9:A400–5

    Article  PubMed  CAS  Google Scholar 

  99. Mackay IR (2010) Travels and travails of autoimmunity: a historical journey from discovery to rediscovery. Autoimmun Rev 9:A251–8

    Article  PubMed  CAS  Google Scholar 

  100. Blank M, Baraam L, Eisenstein M, Fridkin M, Dardik R, Heldman Y, Katchalski-Katzir E, Shoenfeld Y (2011) β2-Glycoprotein-I based peptide regulate endothelial-cells tissue-factor expression via negative regulation of pGSK3b expression and reduces experimental-antiphospholipid-syndrome. J Autoimmun 37:8–17

    Article  PubMed  CAS  Google Scholar 

  101. Shoenfeld Y, Gershwin ME (2005) Intravenous immunoglobulin new indications and mechanisms of action. Clin Rev Allergy Immunol 29:165–166

    Article  Google Scholar 

  102. Sapir T, Shoenfeld Y (2005) Facing the enigma of immunomodulatory effects of intravenous immunoglobulin. Clin Rev Allergy Immunol 29:185–199

    Article  PubMed  CAS  Google Scholar 

  103. Sapir T, Shoenfeld Y (2005) Uncovering the hidden potential of intravenous immunoglobulin as an anticancer therapy. Clin Rev Allergy Immunol 29:307–310

    Article  PubMed  CAS  Google Scholar 

  104. Katz U, Kishner I, Magalashvili D, Shoenfeld Y, Achiron A (2006) Long term safety of IVIG therapy in multiple sclerosis: 10 years experience. Autoimmunity 39:513–517

    Article  PubMed  Google Scholar 

  105. Kessel A, Peri R, Haj T, Snir A, Slobodin G, Sabo E, Rosner I, Shoenfeld Y, Toubi E (2011) IVIG attenuates TLR-9 Activation in B cells from SLE patients. J Clin Immunol 31:31–38

    Article  CAS  Google Scholar 

  106. Blank M, Shoenveld Y (2010) Sialic acid–IVIg targeting CD22. Blood 116:1630–1632

    Article  PubMed  CAS  Google Scholar 

  107. Mieshbach W, Asherson RA, Cervera R, Shoenfeld Y, Gomez Puerta J, Espinosa G, Bucciarelli S (2007) The role of malignancies in patients with catastrophic anti-phospholipid (Asherson's) syndrome. Clin Rheumatol 26:2109–2114

    Article  Google Scholar 

  108. Blank M, Anafi L, Zandman-Goddard G, Krause I, Goldman S, Shalev E, Cervera R, Font J, Fridkin M, Thiesen H-J, Shoenfeld Y (2007) The efficacy of specific IVIG anti-idiotypic antibodies in antiphospholipid syndrome (APS): trophoblast invasiveness and APS animal model. Int Immunol 19:857–865

    Article  PubMed  CAS  Google Scholar 

  109. Sela M, Teitelbaum D (2001) Glatiramer acetate in the treatment of multiple sclerosis. Expert Opin Pharmacother 2:1149–65

    Article  PubMed  CAS  Google Scholar 

  110. Aharoni R, Herschkovitz A, Eilam R, Blumberg-Hazan M, Sela M, Bruck W, Arnon R (2008) Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 12(105):11358–63

    Article  Google Scholar 

  111. Kappos L, Comi G, Panitch H, Oger J, Antel J, Conlon P, Steinman L (2000) Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in Relapsing MS Study Group. Nat Med 6:1176–82

    Article  PubMed  CAS  Google Scholar 

  112. Krogsgaard M, Wucherpfennig KW, Cannella B, Hansen BE, Svejgaard A, Pyrdol J, Ditzel H, Raine C, Engberg J, Fugger L (2000) Visualization of myelin basic protein [MBP] T cell epitopes in MS lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen HLA DR2 MBP 95–99 complex. J Exp Med 191:1395–412

    Article  PubMed  CAS  Google Scholar 

  113. Gaur A, Boehme SA, Chalmers D, Crowe PD, Pahuja A, Ling N, Brocke S, Steinman L, Conlon PJ (1997) Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms. J Neuroimmunol 74:149–58

    Article  PubMed  CAS  Google Scholar 

  114. Blank M, Shoenfeld Y, Cabilly S, Heldman Y, Fridkin M, Katchalski-Katzir E (1999) Prevention of experimental antiphospholipid syndrome and endothelial cell activation by synthetic peptides. Proc Natl Acad Sci U S A 96:5164–8

    Article  PubMed  CAS  Google Scholar 

  115. Tong JC, Sinha AA (2008) Immunological hotspots analyzed by docking simulations: evidence for a general mechanism in pemphigus vulgaris pathology and transformation. BMC Immunol 9:30–9

    Article  PubMed  CAS  Google Scholar 

  116. Arnson Y, Shoenfeld Y, Amital H (2010) Effects of tobacco smoke on immunity, inflammation and autoimmunity. J Autoimmun 34:J258–265

    Article  PubMed  CAS  Google Scholar 

  117. Berkun Y, Padeh S (2010) Environmental factors and the geoepidemiology of juvenile idiopathic arthritis. Autoimmun Rev 9:A319–324

    Article  PubMed  Google Scholar 

  118. Bhat A, Naguwa S, Cheema G, Gershwin ME (2010) The epidemiology of transverse myelitis. Autoimmun Rev 9:A395–399

    Article  PubMed  Google Scholar 

  119. Biggioggero M, Meroni PL (2010) The geoepidemiology of the antiphospholipid antibody syndrome. Autoimmun Rev 9:A299–304

    Article  PubMed  Google Scholar 

  120. Bizzaro N, Tozzoli R, Shoenfeld Y (2007) Are we at a stage to predict autoimmune rheumatic diseases? Arthritis Rheum 56:1736–1744

    Article  PubMed  CAS  Google Scholar 

  121. Borchers AT, Naguwa SM, Keen CL, Gershwin ME (2010) The implications of autoimmunity and pregnancy. J Autoimmun 34:J287–299

    Article  PubMed  CAS  Google Scholar 

  122. Borchers AT, Uibo R, Gershwin ME (2010) The geoepidemiology of type 1 diabetes. Autoimmun Rev 9:A355–365

    Article  PubMed  Google Scholar 

  123. Brooks WH, Le Dantec C, Pers JO, Youinou P, Renaudineau Y (2010) Epigenetics and autoimmunity. J Autoimmun 34:J207–219

    Article  PubMed  CAS  Google Scholar 

  124. Chandran V, Raychaudhuri SP (2010) Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J Autoimmun 34:J314–321

    Article  PubMed  CAS  Google Scholar 

  125. Chang C (2010) The immune effects of naturally occurring and synthetic nanoparticles. J Autoimmun 34:J234–246

    Article  PubMed  CAS  Google Scholar 

  126. Chang C, Gershwin ME (2010) Drugs and autoimmunity—a contemporary review and mechanistic approach. J Autoimmun 34:J266–275

    Article  PubMed  CAS  Google Scholar 

  127. Chen M, Daha MR, Kallenberg CG (2010) The complement system in systemic autoimmune disease. J Autoimmun 34:J276–286

    Article  PubMed  CAS  Google Scholar 

  128. Chen M, Kallenberg CG (2010) The environment, geoepidemiology and ANCA-associated vasculitides. Autoimmun Rev 9:A293–298

    Article  PubMed  CAS  Google Scholar 

  129. Deane S, Teuber SS, Gershwin ME (2010) The geoepidemiology of immune thrombocytopenic purpura. Autoimmun Rev 9:A342–349

    Article  PubMed  Google Scholar 

  130. Ehrenfeld M (2010) Geoepidemiology: the environment and spondyloarthropathies. Autoimmun Rev 9:A325–329

    Article  PubMed  Google Scholar 

  131. Gershwin ME, Goetzl EJ, Steinberg AD (1974) Cyclophosphamide: use in practice. Ann Intern Med 80:531–540

    PubMed  CAS  Google Scholar 

  132. Hemminki K, Li X, Sundquist J, Sundquist K (2010) The epidemiology of Graves' disease: evidence of a genetic and an environmental contribution. J Autoimmun 34:J307–313

    Article  PubMed  CAS  Google Scholar 

  133. Hershko AY, Naparstek Y (2006) Autoimmunity in the era of genomics and proteomics. Autoimmun Rev 5:230–233

    Article  PubMed  CAS  Google Scholar 

  134. Hoffmann MH, Trembleau S, Muller S, Steiner G (2010) Nucleic acid-associated autoantigens: pathogenic involvement and therapeutic potential. J Autoimmun 34:J178–206

    Article  PubMed  CAS  Google Scholar 

  135. Invernizzi P (2010) Geoepidemiology of autoimmune liver diseases. J Autoimmun 34:J300–306

    Article  PubMed  CAS  Google Scholar 

  136. Lambert JF, Nydegger UE (2010) Geoepidemiology of autoimmune hemolytic anemia. Autoimmun Rev 9:A350–354

    Article  PubMed  CAS  Google Scholar 

  137. Lleo A, Invernizzi P, Gao B, Podda M, Gershwin ME (2010) Definition of human autoimmunity—autoantibodies versus autoimmune disease. Autoimmun Rev 9:A259–266

    Article  PubMed  CAS  Google Scholar 

  138. Logan I, Bowlus CL (2010) The geoepidemiology of autoimmune intestinal diseases. Autoimmun Rev 9:A372–378

    Article  PubMed  Google Scholar 

  139. Mackay IR (2005) The etiopathogenesis of autoimmunity. Semin Liver Dis 25:239–250

    Article  PubMed  Google Scholar 

  140. Martin PI, Malizia AI, Rewald E (2008) A propos time and autoimmunity. Clin Rev Allergy Immunol 34:380–384

    Article  PubMed  Google Scholar 

  141. Maverakis E, Miyamura Y, Bowen MP, Correa G, Ono Y, Goodarzi H (2010) Light, including ultraviolet. J Autoimmun 34:J247–257

    Article  PubMed  CAS  Google Scholar 

  142. Mavragani CP, Moutsopoulos HM (2010) The geoepidemiology of Sjogren’s syndrome. Autoimmun Rev 9:A305–310

    Article  PubMed  Google Scholar 

  143. Meyer A, Levy Y (2010) Chapter 33: geoepidemiology of myasthenia gravis. Autoimmun Rev 9:A383–386

    Article  PubMed  Google Scholar 

  144. Meyer N, Misery L (2010) Geoepidemiologic considerations of auto-immune pemphigus. Autoimmun Rev 9:A379–382

    Article  PubMed  CAS  Google Scholar 

  145. Milo R, Kahana E (2010) Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev 9:A387–394

    Article  PubMed  CAS  Google Scholar 

  146. Powell JJ, Faria N, Thomas-McKay E, Pele LC (2010) Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun 34:J226–233

    Article  PubMed  CAS  Google Scholar 

  147. Prieto S, Grau JM (2010) The geoepidemiology of autoimmune muscle disease. Autoimmun Rev 9:A330–334

    Article  PubMed  Google Scholar 

  148. Ranque B, Mouthon L (2010) Geoepidemiology of systemic sclerosis. Autoimmun Rev 9:A311–318

    Article  PubMed  Google Scholar 

  149. Round JL, O’Connell RM, Mazmanian SK (2010) Coordination of tolerogenic immune responses by the commensal microbiota. J Autoimmun 34:J220–225

    Article  PubMed  CAS  Google Scholar 

  150. Sands J, Tuscano JM (2010) Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders. Autoimmun Rev 9:A335–341

    Article  PubMed  Google Scholar 

  151. Segelmark M, Hellmark T (2010) Autoimmune kidney diseases. Autoimmun Rev 9:A366–371

    Article  PubMed  CAS  Google Scholar 

  152. Selmi C (2010) The worldwide gradient of autoimmune conditions. Autoimmun Rev 9:A247–250

    Article  PubMed  Google Scholar 

  153. Selmi C, Tsuneyama K (2010) Nutrition, geoepidemiology, and autoimmunity. Autoimmun Rev 9:A267–270

    Article  PubMed  CAS  Google Scholar 

  154. Shapira Y, Agmon-Levin N, Shoenfeld Y (2010) Defining and analyzing geoepidemiology and human autoimmunity. J Autoimmun 34:J168–177

    Article  PubMed  CAS  Google Scholar 

  155. Shoenfeld Y, Selmi C, Zimlichman E, Gershwin ME (2008) The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity. J Autoimmun 31:325–330

    Article  PubMed  Google Scholar 

  156. Stojanovich L (2010) Stress and autoimmunity. Autoimmun Rev 9:A271–276

    Article  PubMed  CAS  Google Scholar 

  157. Tobon GJ, Youinou P, Saraux A (2010) The environment, geo-epidemiology, and autoimmune disease: rheumatoid arthritis. Autoimmun Rev 9:A288–292

    Article  PubMed  CAS  Google Scholar 

  158. Tomer Y (2010) Hepatitis C and interferon induced thyroiditis. J Autoimmun 34:J322–326

    Article  PubMed  CAS  Google Scholar 

  159. Tonutti E, Visentini D, Bizzaro N (2007) Interpretative comments on autoantibody tests. Autoimmun Rev 6:341–346

    Article  PubMed  CAS  Google Scholar 

  160. Youinou P, Pers JO, Gershwin ME, Shoenfeld Y (2010) Geo-epidemiology and autoimmunity. J Autoimmun 34:J163–167

    Article  PubMed  CAS  Google Scholar 

  161. Zeki AA, Schivo M, Chan AL, Hardin KA, Kenyon NJ, Albertson TE, Rosenquist GL, Louie S (2010) Geoepidemiology of COPD and idiopathic pulmonary fibrosis. J Autoimmun 34:J327–338

    Article  PubMed  CAS  Google Scholar 

  162. Zhao S, Long H, Lu Q (2010) Epigenetic perspectives in systemic lupus erythematosus: pathogenesis, biomarkers, and therapeutic potentials. Clin Rev Allergy Immunol 39:3–9

    Article  PubMed  CAS  Google Scholar 

  163. Renaudineau Y (2010) The revolution of epigenetics in the field of autoimmunity. Clin Rev Allergy Immunol 39:1–2

    Article  PubMed  CAS  Google Scholar 

  164. Matthias T, Pfeiffer S, Selmi C, Gershwin ME (2010) Diagnostic challenges in celiac disease and the role of the tissue transglutaminase-neo-epitope. Clin Rev Allergy Immunol 38:298–301

    Article  PubMed  Google Scholar 

  165. Bhat A, Selmi C, Naguwa SM, Cheema GS, Gershwin ME (2010) Current concepts on the immunopathology of amyloidosis. Clin Rev Allergy Immunol 38:97–106

    Article  PubMed  Google Scholar 

  166. Ikehara S (2010) The future of stem cell transplantation in autoimmune disease. Clin Rev Allergy Immunol 38:292–297

    Article  PubMed  Google Scholar 

  167. Lidar M, Dori A, Levy Y, Lidar Z, Chapman J, Langevitz P (2010) Sarcoidosis presenting as “corset-like” myelopathy: a description of six cases and literature review. Clin Rev Allergy Immunol 38:270–275

    Article  PubMed  Google Scholar 

  168. Carvalheiras G, Vita P, Marta S, Trovao R, Farinha F, Braga J, Rocha G, Almeida I, Marinho A, Mendonca T, Barbosa P, Correia J, Vasconcelos C (2010) Pregnancy and systemic lupus erythematosus: review of clinical features and outcome of 51 pregnancies at a single institution. Clin Rev Allergy Immunol 38:302–306

    Article  PubMed  Google Scholar 

  169. Kivity S, Katz U, Daniel N, Nussinovitch U, Papageorgiou N, Shoenfeld Y (2010) Evidence for the use of intravenous immunoglobulins—a review of the literature. Clin Rev Allergy Immunol 38:201–269

    Article  PubMed  CAS  Google Scholar 

  170. Erlich JF, Paz Z (2010) Postpericardial injury syndrome: an autoimmune phenomenon. Clin Rev Allergy Immunol 38:156–158

    Article  PubMed  Google Scholar 

  171. Ramos-Casals M, Brito-Zeron P, Perez-De-Lis M, Jimenez I, Blanco MJ, Bove A, Soto MJ, Akasbi M, Diaz C, Sentis J, Siso A (2010) Sjogren syndrome or sjogren disease? The histological and immunological bias caused by the 2002 criteria. Clin Rev Allergy Immunol 38:178–185

    Article  PubMed  Google Scholar 

  172. Meron MK, Amital H, Shepshelovich D, Barzilai O, Ram M, Anaya JM, Gerli R, Nicola B, Shoenfeld Y (2010) Infectious aspects and the etiopathogenesis of rheumatoid arthritis. Clin Rev Allergy Immunol 38:287–291

    Article  PubMed  Google Scholar 

  173. Emi Aikawa N, de Carvalho JF, Artur Almeida Silva C, Bonfa E (2010) Immunogenicity of anti-TNF-alpha agents in autoimmune diseases. Clin Rev Allergy Immunol 38:82–89

    Article  PubMed  CAS  Google Scholar 

  174. Blank M, Shoenfeld Y (2010) Antiphospholipid antibody-mediated reproductive failure in antiphospholipid syndrome. Clin Rev Allergy Immunol 38:141–147

    Article  PubMed  CAS  Google Scholar 

  175. Ambrosio P, Lermann R, Cordeiro A, Borges A, Nogueira I, Serrano F (2010) Lupus and pregnancy—15 years of experience in a tertiary center. Clin Rev Allergy Immunol 38:77–81

    Article  PubMed  Google Scholar 

  176. De Carolis S, Botta A, Santucci S, Garofalo S, Martino C, Perrelli A, Salvi S, Ferrazzani S, Caforio L, Scambia G (2010) Predictors of pregnancy outcome in antiphospholipid syndrome: a review. Clin Rev Allergy Immunol 38:116–124

    Article  PubMed  Google Scholar 

  177. Ishii N, Hashimoto T, Zillikens D, Ludwig RJ (2010) High-dose intravenous immunoglobulin (IVIG) therapy in autoimmune skin blistering diseases. Clin Rev Allergy Immunol 38:186–195

    Article  PubMed  CAS  Google Scholar 

  178. Katzav A, Shoenfeld Y, Chapman J (2010) The pathogenesis of neural injury in animal models of the antiphospholipid syndrome. Clin Rev Allergy Immunol 38:196–200

    Article  PubMed  CAS  Google Scholar 

  179. Espirito Santo J, Gomes MF, Gomes MJ, Peixoto LC Pereira S, Acabado A, Freitas J, de Sousa GV (2010) Intravenous immunoglobulin in lupus panniculitis. Clin Rev Allergy Immunol 38:307–318

    Article  PubMed  Google Scholar 

  180. Matthias T, Shoenfeld Y (2010) Challenges for the autoimmunologist. Clin Rev Allergy Immunol 38:75–76

    Article  PubMed  Google Scholar 

  181. Filippini M, Bazzani C, Favalli EG, Marchesoni A, Atzeni F, Sarzi-Puttini P, Pallavicini FB, Caporali R, Gorla R (2010) Efficacy and safety of anti-tumour necrosis factor in elderly patients with rheumatoid arthritis: an observational study. Clin Rev Allergy Immunol 38:90–96

    Article  PubMed  CAS  Google Scholar 

  182. Thomas R, Matthias T, Witte T (2010) Leukocyte immunoglobulin-like receptors as new players in autoimmunity. Clin Rev Allergy Immunol 38:159–162

    Article  PubMed  CAS  Google Scholar 

  183. Ribeiro FM, Szyper-Kravitz M, Klumb EM, Lannes G, Ribeiro FR, Albuquerque EM, Shoenfeld Y (2010) Can lupus flares be associated with tuberculosis infection? Clin Rev Allergy Immunol 38:163–168

    Article  PubMed  CAS  Google Scholar 

  184. Paz Z, Shoenfeld Y (2010) Antifibrosis: to reverse the irreversible. Clin Rev Allergy Immunol 38:276–286

    Article  PubMed  Google Scholar 

  185. Shapira Y, Agmon-Levin N, Shoenfeld Y (2010) Mycobacterium tuberculosis, autoimmunity, and vitamin D. Clin Rev Allergy Immunol 38:169–177

    Article  PubMed  CAS  Google Scholar 

  186. Holland SM (2010) Chronic granulomatous disease. Clin Rev Allergy Immunol 38:3–10

    Article  PubMed  CAS  Google Scholar 

  187. Elhasid R, Rowe JM (2010) Hematopoetic stem cell transplantation in neutrophil disorders: severe congenital neutropenia, leukocyte adhesion deficiency and chronic granulomatous disease. Clin Rev Allergy Immunol 38:61–67

    Article  PubMed  Google Scholar 

  188. Marks DJ, Rahman FZ, Sewell GW, Segal AW (2010) Crohn’s disease: an immune deficiency state. Clin Rev Allergy Immunol 38:20–31

    Article  PubMed  CAS  Google Scholar 

  189. Suhir H, Etzioni A (2010) The role of toll-like receptor signaling in human immunodeficiencies. Clin Rev Allergy Immunol 38:11–19

    Article  PubMed  CAS  Google Scholar 

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  1. The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Ramat gan, Israel

    Yehuda Shoenfeld

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Shoenfeld, Y. The Future of Autoimmunity. Clinic Rev Allerg Immunol 42, 113–120 (2012). https://doi.org/10.1007/s12016-011-8297-4

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