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Pemphigus: A Complex T Cell-dependent Autoimmune Disorder Leading to Acantholysis

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Abstract

Pemphigus is a relatively rare autoimmune bullous disorder involving the skin and mucous epithelia. Clinically characterized by blisters and erosions, its histological hallmark is acantholysis induced by IgG antibodies (ab) against desmoglein 3 and/or desmoglein 1. The role of ab alone in inducing acantholysis is still a matter of debate as several mechanisms could be involved. Another intriguing area of research is the trigger factor inducing autoimmunity in pemphigus patients and the role of T and B cells in this process. This paper will review the data related to the mechanisms of acantholysis between keratinocytes and the role of T cell in this phenomenon.

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Authors and Affiliations

  1. Department of Dermatology and Allergology, Philipps University, Marburg, Germany

    Christian Veldman & Claudio Feliciani

  2. Department of Dermatology, Università Cattolica, Rome, Italy

    Claudio Feliciani

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  1. Christian Veldman
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  2. Claudio Feliciani
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Correspondence to Christian Veldman.

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Veldman, C., Feliciani, C. Pemphigus: A Complex T Cell-dependent Autoimmune Disorder Leading to Acantholysis. Clinic Rev Allerg Immunol 34, 313–320 (2008). https://doi.org/10.1007/s12016-007-8045-y

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  • DOI: https://doi.org/10.1007/s12016-007-8045-y

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