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Inflammatory Mediators in the Immunobiology of Bronchopulmonary Dysplasia

Clinical Reviews in Allergy & Immunology volume 34, pages 174–190 (2008)Cite this article

Abstract

Inflammation is important in the development of bronchopulmonary dysplasia (BPD). Polymorphonuclear cells and macrophages and proinflammatory cytokines/chemokines denote early inflammation in clinical scenarios such as in utero inflammation with chorioamnionitis or initial lung injury associated with respiratory distress syndrome or ventilator-induced lung injury. The persistence and non-resolution of lung inflammation contributes greatly to BPD, including altering the lung’s ability to repair, contributing to fibrosis, and inhibiting secondary septation, alveolarization, and normal vascular development. Further understanding of the role of inflammation in the pathogenesis of BPD, in particular, during the chronic inflammatory period, offers us the opportunity to develop inflammation-related prevention and treatment strategies of this disease that has long-standing consequences for very premature infants.

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Affiliations

  1. Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Buffalo, NY, USA

    Rita M. Ryan, Qadeer Ahmed & Satyan Lakshminrusimha

  2. Department of Pathology and Anatomical Sciences, State University of New York at Buffalo, Buffalo, NY, USA

    Rita M. Ryan

  3. Department of Gynecology–Obstetrics, State University of New York at Buffalo, Buffalo, NY, USA

    Rita M. Ryan

  4. Division of Neonatology, State University of New York at Buffalo, Women and Children’s Hospital of Buffalo, 219 Bryant Street, Buffalo, NY, 14222, USA

    Rita M. Ryan

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  1. Rita M. Ryan
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  2. Qadeer Ahmed
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  3. Satyan Lakshminrusimha
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Correspondence to Rita M. Ryan.

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Ryan, R.M., Ahmed, Q. & Lakshminrusimha, S. Inflammatory Mediators in the Immunobiology of Bronchopulmonary Dysplasia. Clinic Rev Allerg Immunol 34, 174–190 (2008). https://doi.org/10.1007/s12016-007-8031-4

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Keywords

  • Bronchopulmonary dysplasia
  • Inflammatory mediators
  • Premature infants