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Dendritic Cells and Contact Dermatitis

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Abstract

Contact dermatitis is a biological response to simple chemicals in the skin. Although it is well known that allergic contact dermatitis is mediated by the immune system, it is still uncertain whether it is a kind of protective response or it is simply an unnecessary response. We have demonstrated the following: (1) haptens activate Langerhans cells in the initiation phase of murine allergic contact dermatitis in vivo, (2) haptens activate human monocyte-derived dendritic cells in vitro, (3) the activation of dendritic cells by haptens is primarily mediated by the activation of p38 mitogen-activated protein kinase (MAPK), and (4) the activation of p38 MAPK is mediated by stimulation related to an imbalance of intracellular redox. Based on these observations, we will discuss the biological significance of contact dermatitis. In addition, we will review some up-to-date findings on Langerhans cell biology.

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  1. Department of Dermatology, Graduate School of Medicine 1-1, Tohoku University, Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan

    Yoshinori Sasaki & Setsuya Aiba

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  1. Yoshinori Sasaki
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  2. Setsuya Aiba
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Correspondence to Setsuya Aiba.

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Grants: This study was supported in part by the 21st COE program of Tohoku University and by new Energy and Industrial Technology Development Organization.

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Sasaki, Y., Aiba, S. Dendritic Cells and Contact Dermatitis. Clinic Rev Allerg Immunol 33, 27–34 (2007). https://doi.org/10.1007/s12016-007-0034-7

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