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References
Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663–676.
Piskacek, M., Havelka, M., Jendruchova, K., Knight, A., & Keegan, L. P. (2019). The evolution of the 9aaTAD domain in Sp2 proteins: Inactivation with valines and intron reservoirs. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-019-03251-w
Sandholzer, J., Hoeth, M., Piskacek, M., Mayer, H., & de Martin, R. (2007). A novel 9-amino-acid transactivation domain in the C-terminal part of Sox18. Biochemical and Biophysical Research Communications, 360, 370–374.
Piskacek, M., Vasku, A., Hajek, R., & Knight, A. (2015). Shared structural features of the 9aaTAD family in complex with CBP. Molecular BioSystems, 11, 844–851.
Hofrova, A., Lousa, P., Kubickova, M., Hritz, J., Otasevic, T., Repko, M., Knight, A., & Piskacek, M. (2021). Universal two-point interaction of mediator KIX with 9aaTAD activation domains. Journal of Cellular Biochemistry. https://doi.org/10.1002/jcb.30075
Haseeb, A., & Lefebvre, V. (2019). The SOXE transcription factors—SOX8, SOX9 and SOX10—share a bi-partite transactivation mechanism. Nucleic Acids Research. https://doi.org/10.1093/nar/gkz523
Piskacek, M., Havelka, M., Rezacova, M., & Knight, A. (2016). The 9aaTAD transactivation domains: From Gal4 to p53. PLoS ONE, 11, e0162842.
Teufel, D. P., Freund, S. M., Bycroft, M., & Fersht, A. R. (2007). Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. Proceedings of the National academy of Sciences of the United States of America, 104, 7009–7014.
De Guzman, R. N., Goto, N. K., Dyson, H. J., & Wright, P. E. (2006). Structural basis for cooperative transcription factor binding to the CBP coactivator. Journal of Molecular Biology, 355, 1005–1013.
Denis, C. M., Chitayat, S., Plevin, M. J., Wang, F., Thompson, P., Liu, S., Spencer, H. L., Ikura, M., LeBrun, D. P., & Smith, S. P. (2012). Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1. Blood, 120, 3968–3977.
Piskacek, M., Havelka, M., Rezacova, M., & Knight, A. (2017). Gal4 activation domain 9aaTAD could be inactivated by adjacent mini-inhibitory domain and reactivated by distal re-activation domain. bioRxiv. https://doi.org/10.1101/110882
Lam, C. S., Mistri, T. K., Foo, Y. H., Sudhaharan, T., Gan, H. T., Rodda, D., Lim, L. H., Chou, C., Robson, P., Wohland, T., et al. (2012). DNA-dependent Oct4-Sox2 interaction and diffusion properties characteristic of the pluripotent cell state revealed by fluorescence spectroscopy. The Biochemical Journal, 448, 21–33.
Adikusuma, F., Pederick, D., McAninch, D., Hughes, J., & Thomas, P. (2017). Functional equivalence of the SOX2 and SOX3 transcription factors in the developing mouse brain and testes. Genetics, 206, 1495–1503.
Niwa, H., Nakamura, A., Urata, M., Shirae-Kurabayashi, M., Kuraku, S., Russell, S., & Ohtsuka, S. (2016). The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells. BMC Evolutionary Biology, 16, 1–12.
Narayan, S., Bryant, G., Shah, S., Berrozpe, G., & Ptashne, M. (2017). OCT4 and SOX2 work as transcriptional activators in reprogramming human fibroblasts. Cell Reports, 20, 1585–1596.
Lefebvre, V., Angelozzi, M., & Haseeb, A. (2019). SOX9 in cartilage development and disease. Current Opinion in Cell Biology, 61, 39–47.
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This work was supported by the Ministry of Health of the Czech Republic AZV NV19-05-00410.
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Piskacek, M., Otasevic, T., Repko, M. et al. The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4. Stem Cell Rev and Rep 17, 1934–1936 (2021). https://doi.org/10.1007/s12015-021-10225-8
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DOI: https://doi.org/10.1007/s12015-021-10225-8