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Stem Cells for Aging-Related Disorders

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Abstract

This review captures recent advances in biological and translational research on stem cells. In particular, we discuss new discoveries and concepts regarding stem cell treatment of aging-related disorders. A myriad of stem cell sources exists, from hematopoietic to mesenchymal and neural cell lineages. We examine current applications of exogenous adult bone marrow-derived stem cells as an effective and safe transplantable cell source, as well as the use of electrical stimulation to promote endogenous neurogenesis for Parkinson’s disease. We also explore the potential of transplanting exogenous umbilical cord blood cells and mobilizing host resident stem cells in vascular dementia and aging. In addition, we assess the ability of small molecules to recruit resident stem cells in Alzheimer’s disease. Finally, we evaluate mechanisms of action recently implicated in stem cell therapy, such as the role of long non-coding RNAs, G-protein coupled receptor 5, and NeuroD1. Our goal is to provide a synopsis of recent milestones regarding the application of stem cells in aging.

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Funding

This work was Supported in part by NIH NINDS R01 NS058784 (GKS).

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Author notes

  1. Mia C. Borlongan and Jeffrey Farooq contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, 33612, USA

    Mia C. Borlongan, Jeffrey Farooq, Nadia Sadanandan, Zhen-Jie Wang, Blaise Cozene & Jea-Young Lee

  2. Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Gary K. Steinberg

Authors
  1. Mia C. Borlongan
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  2. Jeffrey Farooq
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Contributions

Mia C. Borlongan: Writing (original draft, review, and editing).

Jeffrey Farooq: Writing (original draft, review, and editing).

Nadia Sadanandan: Writing (original draft, review, and editing).

Zhen-Jie Wang: Writing (review, and editing).

Blaise Cozene: Writing (review, and editing).

Jea-Young Lee: Writing (review, and editing).

Gary K Steinberg: Conceptualization, Writing (original draft, review, and editing), Supervision.

Corresponding author

Correspondence to Gary K. Steinberg.

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Borlongan, M.C., Farooq, J., Sadanandan, N. et al. Stem Cells for Aging-Related Disorders. Stem Cell Rev and Rep 17, 2054–2058 (2021). https://doi.org/10.1007/s12015-021-10222-x

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  • DOI: https://doi.org/10.1007/s12015-021-10222-x

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