References
Gohy, S. T., Hupin, C., Fregimilicka, C., Detry, B. R., Bouzin, C., Gaide Chevronay, H., Lecocq, M., Weynand, B., Ladjemi, M. Z., Pierreux, C. E., Birembaut, P., Polette, M., & Pilette, C. (2015). Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition. The European Respiratory Journal, 45, 1258–1272.
Ward, C., Forrest, I. A., Murphy, D. M., Johnson, G. E., Robertson, H., Cawston, T. E., Fisher, A. J., Dark, J. H., Lordan, J. L., Kirby, J. A., & Corris, P. A. (2005). Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients. Thorax, 60, 865–871.
Mahmood, M. Q., Reid, D., Ward, C., Muller, H. K., Knight, D. A., Sohal, S. S., & Walters, E. H. (2017). Transforming growth factor (TGF) β(1) and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis. Respirology, 22, 133–140.
Eapen, M. W. H., Hackett, T., & Sohal, S. (2018). Small airway fibrosis associated with decreased lung function in COPD. Respirology. TSANZ Oral Presentations. Respirology, 23, 21–103.
Mahmood, M. Q., Walters, E. H., Shukla, S. D., Weston, S., Muller, H. K., Ward, C., & Sohal, S. S. (2017). β-catenin, twist and snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction. Scientific Reports, 7, 10832.
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(Comment on: Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and are Deregulated in COPD. Ben Brahim et al.)
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Shukla, S., Ward, C. & Walters, E.H. Mechanistic Insights on EMT and Smoking-Related COPD. Stem Cell Rev and Rep 17, 1503–1504 (2021). https://doi.org/10.1007/s12015-021-10152-8
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DOI: https://doi.org/10.1007/s12015-021-10152-8