Fig. 2
From: Treatment of Aggressive T Cell Lymphoblastic Lymphoma/leukemia Using Anti-CD5 CAR T Cells
CD5-IL15/IL15sushi CAR T cells rapidly reduce patient’s orbital edema. a Prior to CD5-IL15/IL15sushi CAR treatment, the patient’s left eye had significant exophthalmos. Repeat imaging b 1 week after CD5-IL15/IL15sushi CAR infusion, c 2 weeks after infusion, d and 3 weeks following therapy demonstrate rapid resolution of the patient’s swelling. Prior to CD5-IL15/IL15sushi CAR treatment, MRI showed significant edema in the e axial, f sagittal, g and coronal planes. Red arrows and red circle mark the dense soft tissue infiltrate. 8 weeks following CD5-IL15/IL15sushi CAR treatment, repeat MRI imaging shows reduction in the soft tissue mass shadow in the h axial, i sagittal, j and coronal planes