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Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model for Heart Development and Congenital Heart Disease

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Abstract

Congenital heart disease (CHD) remains a significant health problem, with a growing population of survivors with chronic disease. Despite intense efforts to understand the genetic basis of CHD in humans, the etiology of most CHD is unknown. Furthermore, new models of CHD are required to better understand the development of CHD and to explore novel therapies for this patient population. In this review, we highlight the role that human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes can serve to enhance our understanding of the development, pathophysiology and potential therapeutic targets for CHD. We highlight the use of hiPSC-derived cardiomyocytes to model gene regulatory interactions, cell-cell interactions and tissue interactions contributing to CHD. We further emphasize the importance of using hiPSC-derived cardiomyocytes as personalized research models. The use of hiPSCs presents an unprecedented opportunity to generate disease-specific cellular models, investigate the underlying molecular mechanisms of disease and uncover new therapeutic targets for CHD.

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Acknowledgments

We thank Cynthia DeKay and Erik Munsen for assistance with the graphic illustrations. This work was supported by funding from the NHLBI (1R01HL122576) and NHLBI Progenitor Cell Biology Consortium (5U01HL100407).

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The authors indicate no potential conflicts of interest.

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  1. Lillehei Heart Institute, University of Minnesota, 2231 6th St SE, MMC 208, Minneapolis, MN, 55455, USA

    Michelle J. Doyle, Jamie L. Lohr, Christopher S. Chapman, Naoko Koyano-Nakagawa, Mary G. Garry & Daniel J. Garry

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  1. Michelle J. Doyle
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Doyle, M.J., Lohr, J.L., Chapman, C.S. et al. Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model for Heart Development and Congenital Heart Disease. Stem Cell Rev and Rep 11, 710–727 (2015). https://doi.org/10.1007/s12015-015-9596-6

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