Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration

Abstract

Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. In this review, we will discuss the emerging role of MSCs in cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration.

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Acknowledgments

This work was partially supported by grants (R221000068720 and R221000070733) from National University of Singapore, National University Healthcare System, and Ministry of Education, Singapore.

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Correspondence to Wei Seong Toh.

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Toh, W.S., Foldager, C.B., Pei, M. et al. Advances in Mesenchymal Stem Cell-based Strategies for Cartilage Repair and Regeneration. Stem Cell Rev and Rep 10, 686–696 (2014). https://doi.org/10.1007/s12015-014-9526-z

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Keywords

  • Stem cells
  • Mesenchymal stem cells
  • Secretome
  • Extracellular matrix
  • Cartilage
  • Biomaterials
  • Tissue regeneration
  • Tissue engineering