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Stem Cell Reviews and Reports

, Volume 9, Issue 2, pp 184–189 | Cite as

NK and MSCs Crosstalk: The Sense of Immunomodulation and Their Sensitivity

  • Javier G. Casado
  • R. Tarazona
  • F. M. Sanchez-Margallo
Article

Abstract

Several clinical trials are currently evaluating the safety and efficacy of mesenchymal stem cells (MSCs) in different diseases. The MSCs are guided by inflammatory mediators and specific interactions with immune cells occur, especially between MSCs and the cells of the innate immune system. At the present many of these interactions remain to be determined. This review summarizes the current knowledge in relation to the susceptibility of MSCs to NK cell mediated lysis as well as the immunomodulatory activity of MSCs and its control over NK cell function. Here we hypothesize that the inflammatory context will regulate the outcome of NK-MSC interactions.

Keywords

NK cells Mesenchymal stem cells Immunomodulation Innate Response NK cell-mediated lysis 

Notes

Acknowledgments

Subprograma Inncorpora-Torres Quevedo 2011 (PTQ-11-04554). Thanks to V Alvarez and V Crisostomo for critical review and helpful comments. There is no conflict of interest with any financial organization regarding the material discussed in the manuscript.

Disclosure of Potential Conflicts of Interest

The authors declare no conflict of interest or financial interests.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Javier G. Casado
    • 1
  • R. Tarazona
    • 2
  • F. M. Sanchez-Margallo
    • 1
  1. 1.Stem Cell Therapy UnitMinimally Invasive Surgery Centre Jesus UsonCaceresSpain
  2. 2.Immunology Unit, Department of PhysiologyUniversity of ExtremaduraCaceresSpain

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