Stem Cell Reviews and Reports

, Volume 8, Issue 3, pp 863–881 | Cite as

Time-Dependent Processes in Stem Cell-Based Tissue Engineering of Articular Cartilage

  • Ivana Gadjanski
  • Kara Spiller
  • Gordana Vunjak-Novakovic


Articular cartilage (AC), situated in diarthrodial joints at the end of the long bones, is composed of a single cell type (chondrocytes) embedded in dense extracellular matrix comprised of collagens and proteoglycans. AC is avascular and alymphatic and is not innervated. At first glance, such a seemingly simple tissue appears to be an easy target for the rapidly developing field of tissue engineering. However, cartilage engineering has proven to be very challenging. We focus on time-dependent processes associated with the development of native cartilage starting from stem cells, and the modalities for utilizing these processes for tissue engineering of articular cartilage.


Cartilage tissue engineering Mesenchymal stem cells Embryonic stem cells Induced pluripotent stem cells 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ivana Gadjanski
    • 1
    • 2
  • Kara Spiller
    • 1
  • Gordana Vunjak-Novakovic
    • 1
    • 3
  1. 1.Department of Biomedical EngineeringColumbia UniversityNew YorkUSA
  2. 2.R&D Center for BioengineeringMetropolitan University BelgradeKragujevacSerbia
  3. 3.Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical EngineeringColumbia UniversityNew YorkUSA

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