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Time-Dependent Processes in Stem Cell-Based Tissue Engineering of Articular Cartilage

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Abstract

Articular cartilage (AC), situated in diarthrodial joints at the end of the long bones, is composed of a single cell type (chondrocytes) embedded in dense extracellular matrix comprised of collagens and proteoglycans. AC is avascular and alymphatic and is not innervated. At first glance, such a seemingly simple tissue appears to be an easy target for the rapidly developing field of tissue engineering. However, cartilage engineering has proven to be very challenging. We focus on time-dependent processes associated with the development of native cartilage starting from stem cells, and the modalities for utilizing these processes for tissue engineering of articular cartilage.

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Acknowledgments

The authors gratefully acknowledge research funding (NIH grants DE016525, EB002520 and EB011869 to GVN; Fulbright Visiting Scholar grant and grant ON174028 by the Ministry of education and science of Republic of Serbia to IG), and expert help of Dr. Nebojsa Mirkovic in the preparation of figure elements.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Columbia University, New York, NY, USA

    Ivana Gadjanski, Kara Spiller & Gordana Vunjak-Novakovic

  2. R&D Center for Bioengineering, Metropolitan University Belgrade, Prvoslava Stojanovica 6, Kragujevac, 34000, Serbia

    Ivana Gadjanski

  3. Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, 622 W168th St, Vanderbilt Clinic 12-234, New York, NY, 10032, USA

    Gordana Vunjak-Novakovic

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  1. Ivana Gadjanski
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Correspondence to Gordana Vunjak-Novakovic.

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Gadjanski, I., Spiller, K. & Vunjak-Novakovic, G. Time-Dependent Processes in Stem Cell-Based Tissue Engineering of Articular Cartilage. Stem Cell Rev and Rep 8, 863–881 (2012). https://doi.org/10.1007/s12015-011-9328-5

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